Fine Particulate air Pollution is Associated with Higher Vulnerability to Atrial Fibrillation—The APACR Study
dc.contributor.author | Liao, Duanping | |
dc.contributor.author | Shaffer, Michele L. | |
dc.contributor.author | He, Fan | |
dc.contributor.author | Rodriguez-Colon, Sol | |
dc.contributor.author | Wu, Rongling | |
dc.contributor.author | Whitsel, Eric A. | |
dc.contributor.author | Bixler, Edward O. | |
dc.contributor.author | Cascio, Wayne E. | |
dc.date.accessioned | 2016-05-31T17:06:04Z | |
dc.date.available | 2016-05-31T17:06:04Z | |
dc.date.issued | 2011-04 | |
dc.description.abstract | The acute effects and the time course of fine particulate pollution (PM2.5) on atrial fibrillation/flutter (AF) predictors, including P-wave duration, PR interval duration, and P-wave complexity, were investigated in a community-dwelling sample of 106 nonsmokers. Individual-level 24-h beat-to-beat electrocardiogram (ECG) data were visually examined. After identifying and removing artifacts and arrhythmic beats, the 30-min averages of the AF predictors were calculated. A personal PM2.5 monitor was used to measure individual-level, real-time PM2.5 exposures during the same 24-h period, and corresponding 30-min average PM2.5 concentration were calculated. Under a linear mixed-effects modeling framework, distributed lag models were used to estimate regression coefficients (βs) associating PM2.5 with AF predictors. Most of the adverse effects on AF predictors occurred within 1.5–2 h after PM2.5 exposure. The multivariable adjusted βs per 10-µg/m3 rise in PM2.5 at lag 1 and lag 2 were significantly associated with P-wave complexity. PM2.5 exposure was also significantly associated with prolonged PR duration at lag 3 and lag 4. Higher PM2.5 was found to be associated with increases in P-wave complexity and PR duration. Maximal effects were observed within 2 h. These findings suggest that PM2.5 adversely affects AF predictors; thus, PM2.5 may be indicative of greater susceptibility to AF. | en_US |
dc.identifier.citation | Journal of Toxicology and Environmental Health. Part a; 74:11 p. 693-705 | en_US |
dc.identifier.doi | 10.1080/15287394.2011.556056 | |
dc.identifier.issn | 1528-7394 | |
dc.identifier.pmid | pmc3082849 | en_US |
dc.identifier.uri | http://hdl.handle.net/10342/5426 | |
dc.relation.uri | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082849/ | en_US |
dc.title | Fine Particulate air Pollution is Associated with Higher Vulnerability to Atrial Fibrillation—The APACR Study | en_US |
dc.type | Article | en_US |
ecu.journal.issue | 11 | en_US |
ecu.journal.name | Journal of Toxicology and Environmental Health. Part a | en_US |
ecu.journal.pages | 693-705 | en_US |
ecu.journal.volume | 74 | en_US |
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