Does AMP-Activated Protein Kinase Negatively Mediate Aged Fast-Twitch Skeletal Muscle Mass?

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AMP-ActProtKinFTSkelMuscMassGordonetal.pdf (726.67 KB)

Date

2008-10

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Authors

Gordon, Scott Edward
Lake, Jordan A.
Westerkamp, Christopher M.
Thomson, David M.

Journal Title

Journal ISSN

Volume Title

Publisher

East Carolina University

Abstract

The activity of 5'-adenosine monophosphate–activated protein kinase, a negative regulator of cell size, is up-regulated with age in resting and overloaded fast-twitch skeletal muscle but not slowtwitch muscle. Here, we provide evidence to support the hypothesis that elevated 5'-adenosine monophosphate–activated protein kinase activity plays a potentially important integrative role in the age-related atrophy and diminished capacity for growth specific to fast-twitch skeletal muscle. Originally published in Exercise and Sports Sciences Reviews 2008 Vol. 36, No. 4.

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Keywords

Sarcopenia , Aging , Loading , Hypertrophy , Fiber type , Translation , Protein synthesis

Citation

Exercise and Sports Sciences Reviews; 36:4 p. 179-186

DOI

10.1097/JES.0b013e3181877e13

URI

http://hdl.handle.net/10342/3009

Collections

Kinesiology