Does AMP-Activated Protein Kinase Negatively Mediate Aged Fast-Twitch Skeletal Muscle Mass?

Abstract

The activity of 5'-adenosine monophosphate–activated protein kinase, a negative regulator of cell size, is up-regulated with age in resting and overloaded fast-twitch skeletal muscle but not slowtwitch muscle. Here, we provide evidence to support the hypothesis that elevated 5'-adenosine monophosphate–activated protein kinase activity plays a potentially important integrative role in the age-related atrophy and diminished capacity for growth specific to fast-twitch skeletal muscle. Originally published in Exercise and Sports Sciences Reviews 2008 Vol. 36, No. 4.