Physiology: Recent submissions
Now showing items 81-100 of 151
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Physiologic Determinants of Ischemic Skeletal Muscle Pathophysiology
(East Carolina University, 2018-11-29)Lower limb peripheral arterial occlusive disease (PAD) has major impacts on patient quality of life and, in its most severe form, carries a significant risk of mortality. The canonical approach to PAD research has been ... -
Molecular Histology of EphrinA1 Expression in Mouse Heart Visualized Molecular Histology of EphrinA1 Expression in Mouse Heart Visualized with MALDI-MSI
(East Carolina University, 2018-07-25)EphrinA1 is a tyrosine kinase receptor localized in the cellular membrane of healthy cardiomyocytes, the expression of which is lost upon myocardial infarction (MI). Intra-cardiac injection of the recombinant form of ... -
Impact of prostate cancer treatment on pelvic nerve injury and erectile function
(East Carolina University, 2018-07-17)Following prostate cancer treatment, many men will experience urogenital side effects including erectile dysfunction (ED), a condition significantly affecting survivor quality of life. The cause of ED after treatment is ... -
Induced ablation of skeletal muscle-specific estrogen receptor-alpha in adult female mice increased the susceptibility to develop skeletal muscle inflammation and glucose intolerance under chronic lipid overload
(East Carolina University, 2018-04-27)Skeletal muscle-specific ER[alpha] appears to play important roles in regulating skeletal muscle glucose and lipid homeostasis. The overall aim of this dissertation was to determine whether skeletal muscle-specific ER[alpha] ... -
Cardiovascular Outcomes Following Xenobiotic Pulmonary Exposures
(East Carolina University, 2017-07-06)Cardiovascular disease remains the leading cause of mortality in the developed world. Over the past decades, investigations have demonstrated that pulmonary exposure to xenobiotic particulate matter promotes and exacerbates ... -
Modulation of experimental autoimmune myocarditis with cytokine-myosin fusion proteins and novel cardiac peptides
(2016-05-16)Infectious agents that induce cross-reactive myocarditic T cell responses may cause autoimmune inflammation of the heart, dilated cardiomyopathy (DCM), and heart failure. The purpose of this study was to evaluate the ... -
Linking energy state to redox environment through mitochondrial redox circuits
(East Carolina University, 2016-11-16)Mitochondria are the primary producers of intracellular H2O2, an oxidant signaling molecule that has gained attention for its role in normal physiological processes and disease etiologies such as skeletal muscle insulin ... -
Vasodilator-stimulated phosphoprotein regulates arterial smooth muscle cell migration
(East Carolina University, 2016-09-08)Cardiovascular disease (CVD) is a multi-faceted pathology that remains the number one killer of all Americans and people worldwide. Vascular inflammation, endothelial dysfunction, extracellular matrix imbalance, and arterial ... -
Impact of pulmonary exposure to gold core silver nanoparticles of different size and capping agents on cardiovascular injury
(2016-08-24)Background:The uses of engineered nanomaterials have expanded in biomedical technology and consumer manufacturing. Furthermore, pulmonary exposure to various engineered nanomaterials has, likewise, demonstrated the ability ... -
EphA2-receptor deficiency exacerbates myocardial infarction and reduces survival in hyperglycemic mice
(2014-08)Background We have previously shown that EphrinA1/EphA expression profile changes in response to myocardial infarction (MI), exogenous EphrinA1-Fc administration following MI positively influences wound healing, and ... -
Molecular mechanisms of peripheral nerve regeneration: emerging roles of microRNAs
(2013-02)MicroRNAs are small non-coding RNAs that suppress gene expression through target mRNA degradation or translation repression. Recent studies suggest that miRNA plays an important role in multiple physiological and pathological ... -
Control of Vascular Smooth Muscle Cell Growth by Connexin 43
(2012-06)Connexin 43 (Cx43), the principal gap junction protein in vascular smooth muscle cells (VSMCs), regulates movement of ions and other signaling molecules through gap junction intercellular communication (GJIC) and plays ... -
Enhanced Mitochondrial Superoxide Scavenging Does Not Improve Muscle Insulin Action in the High Fat-Fed Mouse
(2015-05)Improving mitochondrial oxidant scavenging may be a viable strategy for the treatment of insulin resistance and diabetes. Mice overexpressing the mitochondrial matrix isoform of superoxide dismutase (sod2tg mice) and/or ... -
Why Does Exercise “Trigger� Adaptive Protective Responses in the Heart?
(2015-05)Numerous epidemiological studies suggest that individuals who exercise have decreased cardiac morbidity and mortality. Pre-clinical studies in animal models also find clear cardioprotective phenotypes in animals that ... -
Deletion of the EphA2 receptor exacerbates myocardial injury and the progression of ischemic cardiomyopathy
(2014-04)EphrinA1-EphA-receptor signaling is protective during myocardial infarction (MI). The EphA2-receptor (EphA2-R) potentially mediates cardiomyocyte survival. To determine the role of the EphA2-R in acute non-reperfused ... -
Expansion of cardiac ischemia/reperfusion injury after instillation of three forms of multi-walled carbon nanotubes
(2012)Background The exceptional physical-chemical properties of carbon nanotubes have lead to their use in diverse commercial and biomedical applications. However, their utilization has raised concerns about human exposure ... -
Identification of cytosolic phosphodiesterases in the erythrocyte: A possible role for PDE5
(2011)Background Within erythrocytes (RBCs), cAMP levels are regulated by phosphodiesterases (PDEs). Increases in cAMP and ATP release associated with activation of β-adrenergic receptors (βARs) and prostacyclin receptors ... -
Essential role of proteasomes in maintaining self-renewal in neural progenitor cells
(2016-01)Protein turnover and homeostasis are regulated by the proteasomal system, which is critical for cell function and viability. Pluripotency of stem cells also relies on normal proteasomal activity that mitigates senescent ... -
Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction
(2011)Mouse models are a valuable tool for studying acute injury and chronic remodeling of the myocardium in vivo. With the advent of genetic modifications to the whole organism or the myocardium and an array of biological and/or ...