Browsing Dissertations by Title
Now showing items 608-627 of 1044
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METHODS OF IDENTIFYING NEUROLOGICAL DELIRIUM (MIND) STUDY
(East Carolina University, 8/5/2020)Delirium is a major concern for critically ill older patients because it is associated with significant risk to quality of life and mortality. The United States spends approximately $164 billion in Medicare funding annually ... -
Microbial community response to environmental change during the Anthropocene
(East Carolina University, 2021-05-03)Microbial community composition and functional potential can be affected by human-derived environmental changes during the Anthropocene with important consequences for elemental cycling and whole ecosystem processes. This ... -
Microglial dysfunction as an early susceptibility to Alzheimer's disease: the exacerbating role of developmental toxicity
(East Carolina University, 2017-07-25)The association between perturbations to neuroimmune development and susceptibility to adult neurodegenerative diseases, like Alzheimer's disease (AD), may undersore a putative pathogenic role for gradual microglial ... -
MICRONOME AND KSHV INFECTION: IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF CELLULAR MICRORNAS DURING VIRUS ENTRY
(East Carolina University, 2018-04-17)Kaposi's sarcoma-associated herpesvirus (KSHV), is the most recently identified human herpesvirus and causes a variety of human malignancies. KSHV is etiologically associated with Kaposi's sarcoma (KS), primary effusion ... -
MINORITY STRESS, RISKY BEHAVIORS, AND SEXUAL SCRIPTING AMONG TRANSGENDER COLLEGE STUDENTS: A MIXED METHODS STUDY
(East Carolina University, 2019-07-11)Despite more transgender and gender nonconforming students entering college, little is known about their minority stress and resilience experiences or about how minority stress and resilience factors influence their sexual ... -
Mobile Assessment of the Dynamic Relationships between Experiential Avoidance, Mood, Stress, and Adherence in Cardiopulmonary Rehabilitation
(East Carolina University, 2020-06-22)Background: Despite the well-documented benefits of attending cardiopulmonary rehabilitation (CVPR) for many patients following acute cardiac or pulmonary events, adherence and completion rates remain suboptimal. Increased ... -
Modern and Classic Quantum Chemistry: Modeling Rhodium-Catalyzed Hydroacylation with Advanced Tools and the Development and Application of Software to Examine Simple Bonding Interactions in a Basis of Molecular Fragments
(East Carolina University, 8/5/2020)In this dissertation, both modern and classic computational methods are utilized to examine two problems of interest in the field of chemistry. The first problem involves a complex rhodium-catalyzed hydroacylation reaction ... -
MODIFICATION OF CELL SURVIVAL RATES BY CERIUM OXIDE NANOPARTICLES FOR EXPOSURE TO PROTON RADIATION
(East Carolina University, 2017-05-03)Radiation therapy is a well-established and widely used treatment for a variety of malignancies in the human body. Current radiotherapy methods most frequently use x-rays to deliver a lethal dose to tumors with sufficient ... -
MODULATING MMP-9 SUBSTRATE PREFERENCE TO REDUCE INFLAMMATION POST-MI
(East Carolina University, 2023-12-08)Worldwide, the prevalence of cardiovascular disease (CVD) is escalating, with myocardial infarction (MI) significantly contributing to the heightened rates of morbidity and mortality. Notably, one in every four MI patients ... -
Modulation of experimental autoimmune myocarditis with cytokine-myosin fusion proteins and novel cardiac peptides
(2016-05-16)Infectious agents that induce cross-reactive myocarditic T cell responses may cause autoimmune inflammation of the heart, dilated cardiomyopathy (DCM), and heart failure. The purpose of this study was to evaluate the ... -
Modulation of IKKβ with AMPK Improves Insulin Sensitivity in Skeletal Muscle
(East Carolina University, 2008-11)Activation of the insulin receptor substrate (IRS)-1 is necessary for proper transduction of the insulin signal. IRS-1 serine312(human)/307(rodent) phosphorylation, however, results in disruption of this signal and subsequent ... -
Molecular characterization of the activation domain of the HTLV-1 HBZ protein and its interaction with the KIX domain of the cellular transcriptional coactivators p300 and CBP
(East Carolina University, 2010)The complex retrovirus human T-cell leukemia virus type I (HTLV-1) is the causative agent of adult T-cell leukemia (ATL). Deregulation of cellular transcription is thought to be a key event in virally-mediated T-cell ... -
Molecular evolution of venom proteins in Ctenidae (Order: Araneae) spiders
(East Carolina University, 2021-01-20)Spiders comprise the largest group of venomous animals and are a pivotal component of the global ecosystem with approximately 50,000 species spread across nearly every habitat on Earth. The family Ctenidae Keyserling, 1877 ... -
Molecular mechanism of anandamide-induced apoptosis in non-melanoma skin cancer.
(East Carolina University, 2015)Non-melanoma skin cancer (NMSC) is the most common cancer in the United States. The absence of selective toxicity is the major problem associated with chemotherapeutic and radiation therapy for NMSCs. The goal of the present ... -
MOLECULAR MECHANISM OF ELLAGIC ACID AND UROLITHIN A IN THE SUPPRESSION OF PROSTATE CANCER BY INFLUENCING THE p53-MDM2 PATHWAY
(East Carolina University, 2019-07-10)Carcinoma of the prostate (CaP) is the most common cancer in men and the second leading cause of cancer-related death in men worldwide. Despite the available treatments for CaP including surgery and Androgen deprivation ... -
MOLECULAR MECHANISM OF THE CYTOTOXIC AND IMMUNOSTIMULATORY ACTIVITY OF 15 DEOXY PROSTAMIDE J2: INVESTIGATION OF CHOP10 AND NFĸB SIGNALING IN COLON CANCER
(East Carolina University, 2019-08-13)The endoplasmic reticulum (ER) stress pathway is a prominent regulator of cancer cell death and as a result, ER stress inducers are being exploited pharmacologically. Cytotoxic ER stress is typically regulated by the ... -
Molecular Mechanisms of Peripheral N-Methyl-D-Aspartate Mediated Pressor Response
(East Carolina University, 2012)The primary goal of this study was to characterize the N-Methyl-D-Aspartate (NMDA) receptor within the cardiovascular system and elucidate the molecular mechanisms involved in peripheral NMDA receptor-mediated pressor ... -
Molecular mechanisms of TMEFF2 action in Prostate Cancer
(East Carolina University, 2013)The transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2) is an evolutionarily conserved type I transmembrane protein expressed in the embryo and limited adult tissues, mainly the brain ... -
Molecular Mechanisms Underlying Cannabidiol-Improved Vocal Recovery Following Damage to a Songbird Vocal Pre-Motor Cortical-Like Region
(East Carolina University, 2023-04-27)The non-euphorigenic phytocannabinoid CBD has been found to be effective in treating childhood-onset epilepsies, conditions that are often associated with developmental delays, including vocal communication. Zebra finch ... -
Motility and chemotaxis in the Lyme disease spirochete Borrelia burgdorferi : role in pathogenesis
(East Carolina University, 2016-08-18)Lyme disease is the most prevalent vector-borne disease in United States and is caused by the spirochete Borrelia burgdorferi. The disease is transmitted from an infected Ixodes scapularis tick to a mammalian host. B. ...