Browsing Dissertations by Title
Now showing items 34-53 of 1044
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A UNIQUE MITOCHONDRIAL BIOENERGETIC PATHWAY UNDERLIES ACUTE MYELOID LEUKEMIA SURVIVAL AND CHEMORESISTANCE
(East Carolina University, 2023-12-01)In his early research on cancer cell metabolism, Otto Warburg made the hypothesis that the respiration of cancer cells has become damaged. The insult to cancer cell respiration, Warburg proposed, was either 1) a decrease ... -
A Wzx-Wzy-like Polysaccharide Biosynthetic Pathway Contributes to Virulence in Brucella abortus 2308 through an Unknown Mechanism
(East Carolina University, 2022-08-05)Brucella abortus is an intracellular pathogen that causes spontaneous abortion in cattle and undulant fever in humans. As a member of the a-proteobacteria, B. abortus is closely related to the bacterial species Caulobacter ... -
A Wzx-Wzy-like Polysaccharide Biosynthetic Pathway Contributes to Virulence in Brucella abortus 2308 through an Unknown Mechanism
(East Carolina University, 2022-08-05)Brucella abortus is an intracellular pathogen that causes spontaneous abortion in cattle and undulant fever in humans. As a member of the a-proteobacteria, B. abortus is closely related to the bacterial species Caulobacter ... -
ACADEMIC AND PSYCHOSOCIAL FACTORS INFLUENCING FEMALE CADETS' INTENT TO PERSIST IN RESERVE OFFICER TRAINING CORPS (ROTC) AND COMMISSION IN THE UNITED STATES AIR FORCE OR ARMY
(East Carolina University, 2013)In spite of representation in enlisted ranks, women are underrepresented among top leadership positions within the military. As the largest commissioning source, ROTC plays a vital role in increasing the number of female ... -
ACADEMIC LIBRARIANS' PERCEPTIONS OF TEAMWORK AND ORGANIZATIONAL STRUCTURE IN A TIME OF RAPID TECHNOLOGICAL CHANGE
(East Carolina University, 2010)The purpose of this study was to explore the perceptions of academic librarians on two topics: the delivery of services to students and faculty in a time of rapid technological changes and an organizational structure ... -
Accuracy of Wet Bulb Globe Temperature (WBGT) Obtained from Regional Weather Station Data for Agricultural Settings in Eastern North Carolina as Proxy for WBGT Obtained from Local Heat Stress Monitors
(East Carolina University, 2022-12-01)Introduction: Agricultural workers are at high risk of suffering from heat stress and subsequently developing heat-related illnesses (HRIs) due to the outdoor nature of their work. This risk can be exacerbated in hot, ... -
Acidosis Activated GPR68 Promotes Vascular Smooth Muscle Cell Growth
(East Carolina University, 2020-12-17)Cardiovascular disease (CVD) is the primary cause of death in the United States and worldwide. Localized extracellular acidosis has been theorized as a possible contributor to CVD pathogenesis, but its precise impact remains ... -
THE ACQUISITION OF NEW STUDENT AFFAIRS PROFESSIONALS' BELIEFS AND PERCEPTIONS ABOUT FACULTY
(East Carolina University, 2013)The purpose of this study is to better understand how new student affairs professionals acquire their beliefs and perceptions about faculty. This study originates from a conceptual framework that includes: (1) a call for ... -
ACUTE CARE NURSES’ KNOWLEDGE ON IN-HOSPITAL STROKES AND PREDICTORS OF KNOWLEDGE
(East Carolina University, 2023-04-21)In-hospital strokes (IHS) account for one in five strokes; however, IHS patients have higher mortality and are half as likely to be discharged home when compared to community-occurring strokes (Chen et al., 2018). Nurse-driven ... -
Adapt & Overcome: Hypoxia Resistance is a Novel Phenotype of the Flexor Digitorum Brevis Skeletal Muscle
(East Carolina University, 2023-11-30)Skeletal muscle comprises the largest mammalian organ system by mass that enables movement, respiration, and thermogenesis. Each of these processes requires the presence of molecular oxygen (O2). Inadequate O2 bioavailability ... -
Adaptation in a Changing World: Evolutionary mechanisms of salt tolerance in a coastal amphibian
(East Carolina University, 2018-07-20)In order to predict evolutionary outcomes of environmental change on populations in nature, we need an improved understanding of the biological mechanisms that affect whether organisms will adapt to a changed environment. ... -
Adaptations of the Hypothalamic Arcuate Nucleus in Response to Exercise and Hunger
(East Carolina University, 2018-05-02)The arcuate nucleus of the hypothalamus serves as a critical node for regulation of mammalian energy balance with the ability to sense the status of many organ systems and exert control over effector arms that potently ... -
Addressing Rising Hospital Acquired Infections (HAIs) Using Novel Nanotechnology: Implications for Public Health Protection
(East Carolina University, 2023-12-11)Globally rising antibiotic-resistant (AR) and multi-drug resistant (MDR) bacterial infections are of public health concern due to lower efficacy of current antibiotic therapy. Specifically, Hospital Acquired Infections ... -
Addressing the Challenge of Preparing Assistant Principals for the Principalship in Moore County
(East Carolina University, 2019-04-23)This problem of practice study attempted to address the challenge of preparing assistant principals for the principalship in Moore County. Across the nation and state, it is a challenge to fill vacant principalships with ... -
Adenosine monophosphate-activated protein kinase inhibits vascular smooth muscle growth associated with vasculoproliferative disorders
(East Carolina University, 2013)Vascular growth disorders are the major contributing factor to cardiovascular disease, the leading cause of morbidity and mortality worldwide. Aberrant vascular smooth muscle cell (VSMC) growth is a primary etiology ... -
Adolescent and Young Adult Oncology Patients and their Caregivers
(East Carolina University, 2016-05-03)Nearly 70,000 adolescents and young adults (AYA; ages 15-39) are diagnosed with cancer each year. Despite AYAs being identified in the late 1990s as a biopsychosocially distinct population from children and adults, they ... -
ADULT ATTACHMENT THEORY AND DIABETES MELLITUS : AN EXAMINATION OF HEALTHCARE UTILIZATION AND BIOPSYCHOSOCIAL HEALTH
(East Carolina University, 2014)Diabetes mellitus (DM) impacts hundreds of millions of individuals and their families around the globe. To explore the relational aspects of care and healthcare utilization two research articles were written: (a) a systematic ... -
Advanced Placement English and First-Year Composition : An Analysis Using Activity Theory with Implications for Transfer
(East Carolina University, 2014)A growing trend in secondary and higher education today is students' ability to earn college credit while still in high school. Currently, there are four main ways for students to earn this early credit: the Advanced ... -
ADVANCING STUDENT SUCCESS AND COLLEGE COMPLETION FOR NONTRADITIONAL STUDENTS: AN EXAMINATION OF DISTANCE EDUCATION PARTICIPATION AND DEGREE ATTAINMENT
(East Carolina University, 2016-12-06)This quantitative ex post facto study examined the relationship between online programming and persistence for the nontraditional student population in higher education. Colleges and universities today are increasing their ... -
ADVANCING THE SCIENCE OF HIRING TEACHERS : AN ANALYSIS OF THE EFFECTS OF TEACHER CHARACTERISTICS ON STUDENT ACHIEVEMENT
(East Carolina University, 2014)This study examined the effect of teacher characteristics on student achievement as measured by the 2011 North Carolina End-of-Course English I exam. The purpose of this study is to identify teacher characteristics with a ...