Browsing Microbiology and Immunology by Author "McCubrey, James A."
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Absence of unsaturated fatty acid synthesis in murine T lymphocytes.
Buttke, Thomas M.; Van Cleave, Steven; Steelman, Linda; McCubrey, James A. (East Carolina University, 1989-08)Stearic acid is toxic for T lymphocytes in vitro but has little effect on B lymphocytes. To investigate the molecular basis for this difference, purified murine T and B lymphocytes were compared for their abilities to ... -
Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation
Simioni, Carolina; Cani, Alice; Martelli, Alberto M.; Zauli, Giorgio; Tabellini, Giovanna; McCubrey, James A.; Capitani, Silvano; Neri, Luca M. (2014-10)The PI3K/Akt/mTOR signaling cascade is a key regulatory pathway controlling cell growth and survival, and its dysregulation is a reported feature of B-precursor acute lymphoblastic leukemia (B-pre ALL). Torin-2 is a ... -
Advances in Targeting Signal Transduction Pathways
McCubrey, James A.; Steelman, Linda S.; Chappell, William H.; Sun, Lin; Davis, Nicole Marie; Abrams, Stephen L.; Franklin, Richard A.; Cocco, Lucio; Evangelisti, Camilla; Chiarini, Francesca; Martelli, Alberto M.; Libra, Massimo; Candido, Saverio; Ligresti, Giovanni; Malaponte, Graziella; Mazzarino, Maria C.; Fagone, Paolo; Donia, Marco; Nicoletti, Ferdinando; Polesel, Jerry; Talamini, Renato; Bäsecke, Jörg; Mijatovic, Sanja; Maksimovic-Ivanic, Danijela; Milella, Michele; Tafuri, Agostino; Dulińska-Litewka, Joanna; Laidler, Piotr; D'Assoro, Antonino B.; Drobot, Lyudmyla B.; Umezawa, Kazuo; Montalto, Giuseppe; Cervello, Melchiorre; Demidenko, Zoya N. (2012-12)Over the past few years, significant advances have occurred in both our understanding of the complexity of signal transduction pathways as well as the isolation of specific inhibitors which target key components in those ... -
The AKT Inhibitor MK-2206 is Cytotoxic in Hepatocarcinoma Cells Displaying Hyperphosphorylated AKT-1 and Synergizes with Conventional Chemotherapy
Simioni, Carolina; Martelli, Alberto M.; Cani, Alice; Cetin-Atalay, Rengul; McCubrey, James A.; Capitani, Silvano; Neri, Luca M. (2013-09)Hepatocellular carcinoma (HCC) is one of the most common potentially lethal human malignancies worldwide. Advanced or recurrent HCC is frequently resistant to conventional chemotherapeutic agents and radiation. Therefore, ... -
Alteration of AKT Activity Increases Chemotherapeutic Drug and Hormonal Resistance in Breast Cancer yet Confers an Achilles Heel by Sensitization to Targeted Therapy
McCubrey, James A.; Sokolosky, Melissa L.; Lehmann, Brian D.; Taylor, Jackson R.; Navolanic, Patrick M.; Chappell, William H.; Abrams, Stephen L.; Stadelman, Kristin M.; Wong, Ellis WT; Misaghian, Negin; Horn, Stefan; Basecke, Jorg; Libra, Massimo; Stivala, Franca; Ligresti, Giovanni; Tafuri, Agostino; Milella, Michele; Zarzycki, Marek; Dzugaj, Andrzej; Chiarini, Francesca; Evangelisti, Camilla; Martelli, Alberto M.; Terrian, David M.; Franklin, Richard A.; Steelman, Linda S. (East Carolina University, 2008)The PI3K/PTEN/Akt/mTOR pathway plays critical roles in the regulation of cell growth. The effects of this pathway on drug resistance and cellular senescence of breast cancer cells has been a focus of our laboratory. ... -
Analysis of the mutation in cutaneous melanoma patients with occupational sun exposure
Candido, Saverio; Rapisarda, Venerando; Marconi, Andrea; Malaponte, Graziella; Bevelacqua, Valentina; Gangemi, Pietro; Scalisi, Aurora; McCubrey, James A.; Maestro, Roberta; Spandidos, Demetrios A.; Fenga, Concettina; Libra, Massimo (2014-03)Sun-exposure is one of the risk factors associated with the development of a cutaneous neoplasm. In melanoma, the Ras-Raf-MEK-ERK (MAPK) signaling pathway is constitutively activated through multiple mechanisms, including ... -
Antitumor Mechanism of the Essential Oils from Two Succulent Plants in Multidrug Resistance Leukemia Cell
McCubrey, James A. (2019-08-26) -
Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics
Evangelisti, Cecilia; Evangelisti, Camilla; Teti, Gabriella; Chiarini, Francesca; Falconi, Mirella; Melchionda, Fraia; Pession, Andrea; Bertaina, Alice; Locatelli, Franco; McCubrey, James A.; Beak, Dong Jae; Bittman, Robert; Pyne, Susan; Pyne, Nigel J.; Martelli, Alberto M. (2014-09)Sphingosine 1-phosphate (S1P) is a bioactive lipid that is formed by the phosphorylation of sphingosine and catalysed by sphingosine kinase 1 (SK1) or sphingosine kinase 2 (SK2). Sphingosine kinases play a fundamental role ... -
Aurora-A Mitotic Kinase Induces Endocrine Resistance through Down-Regulation of ERα Expression in Initially ERα+ Breast Cancer Cells
Opyrchal, Mateusz; Salisbury, Jeffrey L.; Zhang, Shuya; McCubrey, James A.; Hawse, John; Goetz, Matthew P.; Lomberk, Gwen A.; Haddad, Tufia; Degnim, Amy; Lange, Carol A.; Ingle, James N.; Galanis, Evanthia; D'Assoro, Antonino B. (2014)Development of endocrine resistance during tumor progression represents a major challenge in the management of estrogen receptor alpha (ERα) positive breast tumors and is an area under intense investigation. Although the ... -
Cell-to-Cell Lactate Shuttle Operates in Heart and is Important in Age-Related Heart Failure
McCubrey, James A. (2020-02-08) -
Clusterin Enhances AKT2-mediated Motility of Normal and Cancer Prostate Cells Through a PTEN and PHLPP1 Circuit
McCubrey, James A. (2019-07) -
Co-Targeting of Bcl-2 and mTOR Pathway Triggers Synergistic Apoptosis in BH3 Mimetics Resistant Acute Lymphoblastic Leukemia
McCubrey, James A. (2015-09-16) -
Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia
Iacovelli, Stefano; Ricciardi, Maria Rosaria; Allegretti, Matteo; Mirabilii, Simone; Licchetta, Roberto; Bergamo, Paola; Rinaldo, Cinzia; Zeuner, Ann; Foá , Robin; Milella, Michele; McCubrey, James A.; Martelli, Alberto M.; Tafuri, Agostino (2015-10)Several chemo-resistance mechanisms including the Bcl-2 protein family overexpression and constitutive activation of the PI3K/Akt/mTOR signaling have been documented in acute lymphoblastic leukemia (ALL), encouraging ... -
A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia
Chiarini, Francesca; Lonetti, Annalisa; Teti, Gabriella; Orsini, Ester; Bressanin, Daniela; Cappellini, Alessandra; Ricci, Francesca; Tazzari, Pier Luigi; Ognibene, Andrea; Falconi, Mirella; Pagliaro, Pasqualepaolo; Iacobucci, Ilaria; Martinelli, Giovanni; Amadori, Sergio; McCubrey, James A.; Martelli, Alberto M. (2012-12)Signaling through the phosphatidylinositol 3-kinase (PI3K) pathway and its downstream effectors, Akt and mechanistic target of rapamycin (mTOR), is aberrantly activated in acute myeloid leukemia (AML) patients, where it ... -
Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer
Pappalardo, Francesco; Russo, Giulia; Candido, Saverio; Pennisi, Marzio; Cavalieri, Salvatore; Motta, Santo; McCubrey, James A.; Nicoletti, Ferdinando; Libra, Massimo (2016-03)Background Malignant melanoma is an aggressive tumor of the skin and seems to be resistant to current therapeutic approaches. Melanocytic transformation is thought to occur by sequential accumulation of genetic and ... -
Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer
McCubrey, James A. (2016-03-25) -
Cooperative Effects of Akt-1 and Raf-1 on the Induction of Cellular Senescence in Doxorubicin or Tamoxifen Treated Breast Cancer Cells
Taylor, Jackson R.; Lehmann, Brian D.; Chappell, William H.; Abrams, Stephen L.; Steelman, Linda S.; McCubrey, James A. (2011-08)Escape from cellular senescence induction is a potent mechanism for chemoresistance. Cellular senescence can be induced in breast cancer cell lines by the removal of estrogen signaling with tamoxifen or by the accumulation ... -
Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells
Cusimano, Antonella; Puleio, Roberto; D'Alessandro, Natale; Loria, Guido R.; McCubrey, James A.; Montalto, Giuseppe; Cervello, Melchiorre (2015-01)Hepatocellular carcinoma (HCC) is characterized by limited response to current drug therapies. Here, we report that SC66, a novel AKT inhibitor, reduced cell viability in a dose- and time-dependent manner, inhibited colony ... -
Cytotoxic Activity of the Novel Small Molecule AKT Inhibitor SC66 in Hepatocellular Carcinoma Cells
McCubrey, James A. (2015-01-30) -
Cytotoxic Activity of the Novel Small Molecule AKT Inhibitor SC66 in Hepatocellular Carcinoma Cells
McCubrey, James A. (2015)