Browsing Microbiology and Immunology by Author "Mesnard, Jean-Michel"
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HBZ inhibits the HAT activity of the cellular coactivators p300 and CBP
Wright, Diana Grace; Wurm, Torsten; Polakowski, Nicholas; Mesnard, Jean-Michel; Lemasson, Isabelle (2011-) -
The HTLV-1-encoded protein HBZ directly inhibits the acetyl transferase activity of p300/CBP
Wurm, Torsten; Wright, Diana Grace; Polakowski, Nicholas; Mesnard, Jean-Michel; Lemasson, Isabelle (2012-07)The homologous cellular coactivators p300 and CBP contain intrinsic lysine acetyl transferase (termed HAT) activity. This activity is responsible for acetylation of several sites on the histones as well as modification of ... -
Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Protein Interacts with the Cellular Transcription Factor CREB To Inhibit HTLV-1 Transcription
Lemasson, Isabelle; Lewis, Matthew R.; Polakowski, Nicholas; Hivin, Patrick; Cavanagh, Marie-Helene; Thebault, Sabine; Barbeau, Benoit; Nyborg, Jennifer K.; Mesnard, Jean-Michel (East Carolina University, 2007-02)The complex human T-cell leukemia virus type 1 (HTLV-1) retrovirus encodes several proteins that are unique to the virus within its 3 -end region. Among them, the viral transactivator Tax and posttranscriptional regulator ... -
JunD/HBZ enhances HBZ enhances HTLV-1 antisense transcription
Peloponese, Jean-Marie; Lemasson, Isabelle; Barbeau, Benoit; Mesnard, Jean-Michel (2011)Infection with the human T-cell leukemia virus type 1 (HTLV-1) results in a variety of diseases including adult T-cell leukemia (ATL), a fatal malignancy characterized by the uncontrolled proliferation of virally infected ... -
Upregulation of Human T-Cell Leukemia Virus Type 1 Antisense Transcription by the Viral Tax Protein
Landry, Sebastien; Halin, Marilene; Vargas, Amandine; Lemasson, Isabelle; Mesnard, Jean-Michel; Barbeau, Benoit (East Carolina University, 2009-02)Several studies have recently demonstrated the existence of human T-cell leukemia virus type 1 (HTLV-1) antisense transcripts, which allow the synthesis of the newly described HBZ protein. Although previous reports have ...