Browsing Microbiology and Immunology by Author "Parker, Anita C."
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Analysis of Six tonB Gene Homologs in Bacteroides Fragilis Revealed That tonB3 is Essential for Survival in Experimental Intestinal Colonization and Intra-Abdominal Infection
Parker, Anita C.; Seals, Nathaniel L.; Rocha, Edson R.; Baccanale, Cecile L. (2022-01-25) -
Analysis of the Zinc Finger Domain of TnpA, a DNA Targeting Protein Encoded by Mobilizable Transposon Tn4555
Bacic, Melissa K.; Jain, Jinesh C.; Parker, Anita C.; Smith, C. Jeffrey (East Carolina University, 2007-07)The mobilizable transposon Tn4555, found in Bacteroides spp., is an important antibiotic resistance element encoding a broad spectrum beta-lactamase. Tn4555 is mobilized by conjugative transposons such as CTn341 which can ... -
The Bacteroides mobilizable transposon Tn4555 integrates by a site-specific recombination mechanism similar to that of the gram-positive bacterial element Tn916
Tribble, Gena D.; Parker, Anita C.; Smith, C. Jeffrey (East Carolina University, 1997-04)The Bacteroides mobilizable transposon Tn4555 is a 12.2-kb molecule that encodes resistance to cefoxitin. Conjugal transposition is hypothesized to occur via a circular intermediate and is stimulated by coresident tetracycline ... -
Cloning and characterization of the endogenous cephalosporinase gene, cepA, from Bacteroides fragilis reveals a new subgroup of Ambler class A beta-lactamases.
Rogers, Marc B.; Parker, Anita C.; Smith, C. Jeffrey (East Carolina University, 1993-11)Bacteroides frgiglis CS30 is a clinical isolate resistant to high concentrations of benzylpenicillin and cephaloridine but not to cephamycin or penem antibiotics. beta-Lactam resistance is mediated by a chromosomally encoded ... -
Genetic and biochemical analysis of a novel Ambler class A β-Lactamase responsible for cefoxitin resistance in Bacteroides species.
Parker, Anita C.; Smith, C. Jeffrey (East Carolina University, 1993-05)A clinical isolate of Bacteroides vulgatus was resistant to tetracycline, clindamycin, ampicillin, cephaloridine, cefoxitin, and other 13-lactam antibiotics except imipenem. 13-Lactam resistance was mediated by a ... -
Genetic and Structural Analysis of the Bacteroides Conjugative Transposon CTn341
Bacic, Melissa K.; Parker, Anita C.; Stagg, J.; Whitley, H. P.; Wells, W. G.; Jacob, L. A.; Smith, C. J. (East Carolina University, 2005-04)The genetic structure and functional organization of a Bacteroides conjugative transposon (CTn), CTn341, were determined. CTn341 was originally isolated from a tetracycline-resistant clinical isolate of Bacteroides vulgatus. ... -
Identification of a circular intermediate in the transfer and transposition of Tn4555, a mobilizable transposon from Bacteroides spp.
Smith, C. Jeffrey; Parker, Anita C. (East Carolina University, 1993-05)Transmissible cefoxitin (FX) resistance in Bacteroides vulgatus CLA341 was associated with the 12.5-kb, mobilizable transposon, Tn4555, which encoded the 13-lactamase gene cfxA. Transfer occurred by a conjugation-like ... -
Molecular and genetic analysis of the Bacteroides uniformis cephalosporinase gene, cblA, encoding the species-specific beta-lactamase.
Smith, C. Jeffrey; Bennett, Tamara K.; Parker, Anita C. (East Carolina University, 1994-08)The gene, cbl, encoding the species-specific, clavulanate-susceptible, endogenous cephalosporinase was cloned from Bacteroides uniforinis WAL-7088. The nucleotide sequence was determined, and the cbl structural gene was ... -
A Multicomponent System Is Required for Tetracycline-Induced Excision of Tn4555
Parker, Anita C.; Smith, C. Jeffrey (East Carolina University, 2004-01)Bacteroides spp. are the predominant organisms in the intestinal tract, and they also are important opportunistic pathogens. Antibiotic therapy of Bacteroides infections often is complicated by the prevalence of drug-resistant ... -
The Transfer Origin for Bacteroides Mobilizable Transposon Tn4555 Is Related to a Plasmid Family from Gram-Positive Bacteria
Smith, C. Jeffrey; Parker, Anita C. (East Carolina University, 1998-01)Conjugal transfer of Bacteroides mobilizable transposon Tn4555 was examined with an Escherichia coli-based assay system. It was shown that mobilization required the cis-acting oriTTn region and that the Tn4555 mobATn gene ...