Browsing Microbiology and Immunology by Author "Polakowski, Nicholas"
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Direct Inhibition of RNAse T2 Expression by the HTLV-1 Viral Protein Tax
Polakowski, Nicholas; Han, Hongjin; Lemasson, Isabelle (2011-08)Adult T-cell leukemia (ATL) is one of the primary diseases caused by Human T-cell Leukemia Virus type 1 (HTLV-1) infection. The virally-encoded Tax protein is believed to initiate early events in the development of this ... -
HBZ inhibits the HAT activity of the cellular coactivators p300 and CBP
Wright, Diana Grace; Wurm, Torsten; Polakowski, Nicholas; Mesnard, Jean-Michel; Lemasson, Isabelle (2011-) -
HTLV-1 Tax directly modulates expression of the CDK6 and RNASET2 genes
Polakowski, Nicholas; Han, Hongjin; Lemasson, Isabelle (2011) -
The HTLV-1-encoded protein HBZ directly inhibits the acetyl transferase activity of p300/CBP
Wurm, Torsten; Wright, Diana Grace; Polakowski, Nicholas; Mesnard, Jean-Michel; Lemasson, Isabelle (2012-07)The homologous cellular coactivators p300 and CBP contain intrinsic lysine acetyl transferase (termed HAT) activity. This activity is responsible for acetylation of several sites on the histones as well as modification of ... -
Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Protein Interacts with the Cellular Transcription Factor CREB To Inhibit HTLV-1 Transcription
Lemasson, Isabelle; Lewis, Matthew R.; Polakowski, Nicholas; Hivin, Patrick; Cavanagh, Marie-Helene; Thebault, Sabine; Barbeau, Benoit; Nyborg, Jennifer K.; Mesnard, Jean-Michel (East Carolina University, 2007-02)The complex human T-cell leukemia virus type 1 (HTLV-1) retrovirus encodes several proteins that are unique to the virus within its 3 -end region. Among them, the viral transactivator Tax and posttranscriptional regulator ... -
Inhibition of histone acetyltransferase (HAT) activity by HBZ extends beyond the p300/CBP HAT family
Wright, Diana Grace; Polakowski, Nicholas; Lemasson, Isabelle (2014)We previously reported that HTLV-1 basic leucine zipper factor (HBZ) interacts with the cellular coactivator p300 in cells derived from ATL patients. We further determined that HBZ directly binds to the histone acetyltransferase ...