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THE SYNTHESIS, STRUCTURE AND PHOTOPHYSICAL PROPERTIES OF PHOSPHORESCENT CYCLOMETALATED N^N^C-COORDINATED PLATINUM COMPLEXES
(East Carolina University, 2016-07-25)
Phosphorescent materials based on cyclometalated platinum complexes have attracted a great deal of attention because of their potential in chemical, biological and optoelectronic applications, specifically as emitters in ...
Investigation of the Zinc binding region of Prothymosin-alpha : A spectroscopic and thermodynamic approach to study metal binding in Intrinsically disordered proteins
(East Carolina University, 2014)
The goal of this study is to provide a deeper insight into how metals bind intrinsically disordered proteins (IDPs) by taking zinc binding to prothymosin-alpha as a case study. The involvement of metals in several diseases ...
SYNTHESIS AND SPECTROSCOPIC PROPERTIES OF BOC- PROTECTED FLUORESCENT ARGININE
(East Carolina University, 2017-08-21)
Small peptides capable of penetrating or spanning the hydrophobic core of lipid bilayers have many potential uses in medicine and in biochemical research. As the most basic of the amino acids that can comprise such peptides, ...
Quinone Formation via Ceric Ammonium Nitrate Oxidations of 2-Alkyl-1,4-dialkoxybenzenes
(East Carolina University, 2016-05-03)
Quinones are cyclohexadiendiones that have a variety of uses ranging from medical applications to synthetic building blocks. Medicinal applications stem from the potent biological activity (e.g. antitumor and antibiotic) ...
A quantitative and nondestructive method for determining the degradation of waterlogged archaeological wood
(East Carolina University, 2013)
Archaeological artifacts are an essential part of preserving history and culture, and can be valuable tools for enhancing education and contributing economic benefits through tourism. Of the artifacts that one may encounter, ...
Synthesis Of Non-Natural Fmoc-Protected Amino Acids To Provide Novel Fluorescent Anion Probes And Their Incorporation Into Synthetic Peptides
(East Carolina University, 2015)
Cystic fibrosis is a genetic disorder caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. CFTR serves to control the gradient of chloride and bicarbonate ions across the cellular ...
Using Fluorescent Probes to Study the Location and Interaction of Disaccharides within Lipid Bilayers
(East Carolina University, 2016-04-26)
It is well known that certain organisms, such as the tardigrade, are capable of surviving extreme conditions including dehydration, freezing and / or oxygen deficiency. The tardigrades ability to withstand such extreme ...
Oxidation of Isoprene to Methyl vinyl ketone and Methacrolein via Hydroxyl Radical : A Regenerative Mechanism for the Hydroxyl Radical
(East Carolina University, 2013)
Isoprene is an important molecule in atmospheric chemistry. Belonging to a class of molecules known as volatile organic compounds, it undergoes reactions with several different oxidizers in the atmosphere, including ...
A Molecular Dynamics Study into Annexin A1 Induced Membrane Binding and Aggregation
(East Carolina University, 2010)
Annexins constitute a family of proteins that bind to anionic membranes in a reversible and calcium dependent manner through the unique architecture of their calcium binding sites. In addition, annexins with relatively ...