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Cu²⁺ Binding to A[beta] peptides : Detailed Heat Capacity Studies Provide Structural Insight into Complex Formation
(East Carolina University, 2012)
Alzheimer's disease (AD), an irreversible, progressive and devastating neurodegenerative disease, is the most common cause of dementia. It is characterized by the extracellular amyloid plaques and the intracellular ...
Synthesis, structure, photophysics, and biological activity of platinum (II) complexes
(East Carolina University, 2013)
The synthesis, structure, and photophysical properties of luminescent platinum (II) complexes with different coordination patterns, (C^C*N^N), (N^C*N), (N^N*C) and (N^N^C) are reported, where "C^N or N^N" denotes a bidentate ...
Elucidating the Mechanism of Action of Unnatural Amino Acid Containing Antimicrobial Peptides in Membrane Environments
(East Carolina University, 2012)
Organism resistance continues to develop to the currently available antimicrobial compounds necessitating the development of innovative new therapeutic compounds with different specificities and mechanisms of action that ...
ELECTROCHEMICAL DETECTION OF BENZO[A]PYRENE METABOLITE DNA DAMAGE : IMPLICATIONS OF NUCLEOBASE SEQUENCE AND ADDUCT STEREOCHEMISTRY
(East Carolina University, 2011)
Xenobiotics are chemical compounds introduced to living organisms that originate outside the body. A well-studied xenobiotic is benzo[a]pyrene (BP), a polyaromatic hydrocarbon (PAH) primarily introduced into the body via ...
SYNTHESIS AND PHOTOPHYSICAL CHARACTERIZATION OF TRIDENTATE C^N*N PLATINUM (II) COMPLEXES and, INVESTIGATION OF SELECTIVITY IN C-H BOND ACTIVATION BY PLATINUM
(East Carolina University, 2012)
The synthesis, structure, and photophysical properties of a series of novel, highly luminescent tridentate platinum complexes with general coordination geometry of (C^N*N)-PtL are reported, where "C^N" denotes a coordination ...
Thermodynamic Investigations into Copper Binding in the N-Terminal Region of the Prion Protein at Low Copper Loadings
(East Carolina University, 2010)
The prion protein (PrP) is a naturally occurring protein found at high levels in central nervous system (CNS). The misfolding of the PrP is responsible for neurodegenerative diseases called transmissible spongioform ...
Extraction of Salvia miltiorrhiza Using Subcritical Water
(2014)
Salvia miltiorrhiza, also known as Danshen, is an herb commonly used in Chinese medicine to treat cardiovascular and other diseases. As it has recently gained more recognition, this herb is currently being investigated for ...
The Duff Reaction: Researching A Modification
(2014)
Formylation reactions are used to synthesize aldehydes. The Duff reaction is a formylation reaction that uses phenol derivatives, hexamethylenetetramine, acetic acid, and acid to synthesis ortho substituted aromatic ...
Benzoate: The Quantitation of Soft Drinks Implicated in Obesity
(East Carolina University, 2019-04-26)
Research has shown that childhood obesity is a leading cause of diseases such as coronary artery disease, hypertension, type 2 diabetes, cancer, osteoarthritis, and many more. With approximately 17 percent of the United ...
A Calorimetric and Spectroscopic Study of the Interactions Between Model Lipid Membrane Bilayers and Simple Sugars
(East Carolina University, 2015)
It is well known that various organisms, such as the tardigrade, naturally use carbohydrates, particularly disaccharides, to help preserve their cell structural and functional integrity during freezing or dehydration. There ...