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Label-free classification of cultured cells through diffraction imaging
(2011-05)
Automated classification of biological cells according to their 3D morphology is highly desired in a flow cytometer setting. We have investigated this possibility experimentally and numerically using a diffraction imaging ...
Feasibility Study of Dual Energy Radiographic Imaging for Target Localization in Radiotherapy for Lung Tumors
(2014)
Purpose
Dual-energy (DE) radiographic imaging improves tissue discrimination by separating soft from hard tissues in the acquired images. This study was to establish a mathematic model of DE imaging based on intrinsic ...
A new assessment model for tumor heterogeneity analysis with [18]F-FDG PET images
(2016-01)
It has been shown that the intratumor heterogeneity can be characterized with quantitative analysis of the [18]F-FDG PET image data. The existing models employ multiple parameters for feature extraction which makes it ...
Resolving power of diffraction imaging with an objective: a numerical study
(2017-05)
Diffraction imaging in the far-field can detect 3D morphological features of an object for its coherent nature. We describe methods for accurate calculation and analysis of diffraction images of scatterers of single and ...
Quantitative analysis and comparison of 3D morphology between viable and apoptotic MCF-7 breast cancer cells and characterization of nuclear fragmentation
(2017-09-08)
Morphological changes in apoptotic cells provide essential markers for defining and detection
of apoptosis as a fundamental mechanism of cell death. Among these changes, the
nuclear fragmentation and condensation have ...
Realistic optical cell modeling and diffraction imaging simulation for study of optical and morphological parameters of nucleus
(2016-01)
Coherent light scattering presents complex spatial patterns that depend on morphological and molecular features of biological cells. We present a numerical approach to establish realistic optical cell models for generating ...