Browsing Brody School of Medicine by Title
Now showing items 1-20 of 341
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The 52nd Annual Wind River Conference on Prokaryotic Biology -- 2008
(East Carolina University, 2008-12) -
Abraham Flexner and the black medical schools.
(East Carolina University, 2006-09)"Abraham Flexner and the Black Medical Schools" first appeared in Beyond Flexner: Medical Education in the Twentieth Century, Barbara Barzansky and Norman Gevitz, eds. Copyright 1992 by Barbara Barzansky and Norman Gevitz. ... -
Absence of unsaturated fatty acid synthesis in murine T lymphocytes.
(East Carolina University, 1989-08)Stearic acid is toxic for T lymphocytes in vitro but has little effect on B lymphocytes. To investigate the molecular basis for this difference, purified murine T and B lymphocytes were compared for their abilities to ... -
The Actin Binding Protein, Fesselin, is a Member of the Synaptopodin Family
(East Carolina University, 2008-07)Fesselin is a natively unfolded protein that is abundant in avian smooth muscle. Like many natively unfolded proteins, fesselin has multiple binding partners including actin, myosin, calmodulin and α-actinin. Fesselin ... -
Activation of the proton sensing G-protein coupled receptor, GPR4, regulates focal adhesion dynamics and delays cell spreading due to increased cytoskeletal tension
(East Carolina University, 2013)The tumor microenvironment is characteristically acidic due to insufficient blood perfusion, chronic inflammation, hypoxia, and altered cell metabolism. The low pH found in the tumor microenvironment may facilitate the ... -
Adaptations of Pseudomonas aeruginosa to the Cystic Fibrosis Lung Environment Can Include Deregulation of zwf, Encoding Glucose-6-Phosphate Dehydrogenase
(East Carolina University, 2005-11)Cystic fibrosis (CF) patients are highly susceptible to chronic pulmonary disease caused by mucoid Pseudomonas aeruginosa strains that overproduce the exopolysaccharide alginate. We showed here that a mutation in zwf, ... -
Aerobic-Type Ribonucleotide Reductase in the Anaerobe Bacteroides fragilis
(East Carolina University, 2002-02)Bacteroides fragilis, a component of the normal intestinal flora, is an obligate anaerobe capable of long-term survival in the presence of air. Survival is attributed to an elaborate oxidative stress response that controls ... -
Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury
(East Carolina University, 2000-09-12)Antagonists of glutamate receptors of the N-methyl-D-aspartate subclass (NMDAR) or inhibitors of nitric oxide synthase (NOS) prevent nervous system plasticity. Inflammatory and neuropathic pain rely on plasticity, presenting ... -
Allopurinol improves myocardial reperfusion injury in a xanthine oxidase-free model
(East Carolina University, 1995-07)The ability of allopurinol to protect against reperfusion injury in the heart has usually been attributed to its xanthine oxidase (XO)- inhibiting properties. Human myocardium how- ever, has exhibited low levels of XO ... -
Alteration of AKT Activity Increases Chemotherapeutic Drug and Hormonal Resistance in Breast Cancer yet Confers an Achilles Heel by Sensitization to Targeted Therapy
(East Carolina University, 2008)The PI3K/PTEN/Akt/mTOR pathway plays critical roles in the regulation of cell growth. The effects of this pathway on drug resistance and cellular senescence of breast cancer cells has been a focus of our laboratory. ... -
Altered expression of circadian clock gene, mPer1, in mouse brain and kidney under morphine dependence and withdrawal
(East Carolina University, 2006-08-22)Every physiological function in the human body exhibits some form of circadian rhythmicity. Under pathological conditions, however, circadian rhythmicity may be dusrupted. Patients infected with HIV or addicted to drugs ... -
Alveolar macrophage priming by intravenous administration of chitin particles, polymers of N-acetyl-D-glucosamine, in mice
(East Carolina University, 1997-03)Intravenous (i.v.) administration of phagocytosable chitin particles (1 to 10 mm) in C57BL/6 mice and SCID mice primed alveolar macrophages (Mf) within 3 days to yield up to a 50-fold increase in their oxidative burst when ... -
American Ginseng Modifies 137Cs-Induced DNA Damage and Oxidative Stress in Human Lymphocytes
(East Carolina University, 2009-01-01)The multifold bioactive medicinal properties of ginseng have been closely linked to its antioxidative ability, which is related to its ginsenoside content. Since the key mechanism of radiation-induced cell death and tissue ... -
Amyloid-beta peptide A beta p3-42 affects early aggregation of full-length A beta 1-42
(East Carolina University, 2009-05)The major amyloid beta (Aβ) peptides found in the brain of familial and late onset Alzheimer’s disease include the full-length Aβ1-42 and N-terminally truncated, pyroglutamylated peptides Aβp3-42 and Aβp11-42. The ... -
Analysis of rRNA restriction fragment length polymorphisms from Bacteroides spp. and Bacteroides fragilis isolates associated with diarrhea in humans and animals.
(East Carolina University, 1992-04)The Escherichia coli rRNA operon rrnB was used as a 32P-labeled hybridization probe in Southern blots of genomic DNAs from representative strains of the saccharolytic, gram-negative, obligate anaerobes of the genus Bacteroides. ... -
Analysis of the Zinc Finger Domain of TnpA, a DNA Targeting Protein Encoded by Mobilizable Transposon Tn4555
(East Carolina University, 2007-07)The mobilizable transposon Tn4555, found in Bacteroides spp., is an important antibiotic resistance element encoding a broad spectrum beta-lactamase. Tn4555 is mobilized by conjugative transposons such as CTn341 which can ... -
Another dimension to the black Diaspora. Diet, disease, and racism
(East Carolina University, 1983-07) -
Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants
(East Carolina University, 2008-07)Many chemotherapy drugs are known to cause significant clinical neurotoxicity, which can result in the early cessation of treatment. To identify and develop more effective means of neuroprotection it is important to ... -
Anti-growth properties of BAY 41-2272 in vascular smooth muscle cells
(East Carolina University, 2009-02)Vascular smooth muscle (VSM) growth is integral in the pathophysiology of blood vessel diseases, and identifying approaches that have capacity to regulate VSM growth is critically essential. Cyclic nucleotide signaling has ...