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Oral citrulline as arginine precursor may be beneficial in sickle cell disease: early phase two results.
(East Carolina University, 2001-10)
L-Arginine may be a conditionally essential amino acid in children and adolescents with sickle cell disease, particularly as required substrate in the arginine-nitric oxide pathway for endogenous nitrovasodilation and ...
An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects.
(East Carolina University, 1988-08)
We have developed an in vitro muscle preparation suitable for metabolic studies with human muscle tissue and have investigated the effects of obesity and non-insulin-dependent diabetes mellitus (NIDDM) on glucose transport. ...
Identification of E2F1 as a positive transcriptional regulator for delta-catenin
(East Carolina University, 2008-05-02)
Delta-Catenin is upregulated in human carcinomas. However, little is known about the potential transcriptional factors that regulate delta-catenin expression in cancer. Using a human delta-catenin reporter system, we have ...
Differences in reproductive risk factors for breast cancer in middle-aged women in Marin County, California and a sociodemographically similar area of Northern California
(East Carolina University, 2009-03-25)
Background: The Northern California county of Marin (MC) has historically had high breast cancer incidence rates. Because of MC's high socioeconomic status (SES) and racial homogeneity (non-Hispanic White), it has been ...
Differential regulation of the attachment of KSHV infected human B cells to ECM by KSHV encoded gB and cellular alpha-V integrins
(East Carolina University, 2008-07)
Kaposi’s sarcoma-associated herpesvirus (KSHV) has two modes replication: latent and lytic replication. Reactivation from latency is dictated, in part, by the cell cycle. Herein, we have attempted to delineate the importance ...
Conservation of the regulated structure of folded myosin 2 in species separated by at least 600 million years of independent evolution
(East Carolina University, 2008-04-22)
The myosin 2 family of molecular motors includes isoforms regulated
in different ways. Vertebrate smooth-muscle myosin is activated by phosphorylation of the regulatory light chain, whereas scallop striated adductor-muscle ...
Contractile activity restores insulin responsiveness in skeletal muscle of obese Zucker rats.
(East Carolina University, 1993-01-15)
Both insulin and contraction stimulate glucose transport in skeletal muscle. Insulin-stimulated glucose transport is decreased in obese humans and rats. The aims of this study were (1) to determine if contraction-stimulated ...
Predifferentiated Embryonic Stem Cells Prevent Chronic Pain Behaviors and Restore Sensory Function Following Spinal Cord Injury in Mice
(East Carolina University, 2006)
Embryonic stem (ES) cells have been investigated in repair of the CNS following neuronal injury and disease; however, the efficacy of these cells in treatment of postinjury pain is far from clear. In this study, we evaluated ...
Alveolar macrophage priming by intravenous administration of chitin particles, polymers of N-acetyl-D-glucosamine, in mice
(East Carolina University, 1997-03)
Intravenous (i.v.) administration of phagocytosable chitin particles (1 to 10 mm) in C57BL/6 mice and SCID mice primed alveolar macrophages (Mf) within 3 days to yield up to a 50-fold increase in their oxidative burst when ...
The role of the proximal small intestine in improvements in diabetes resolution and insulin sensitivity following bariatric surgery in type 2 diabetes
(East Carolina University, 2011)
Bariatric surgery is an effective, rapid, and durable treatment for obesity and type 2 diabetes mellitus (T2DM). Roux-en Y Gastric Bypass (RYGB) resolves T2DM in 80% of cases, while gastric banding (LAGB) resolves T2DM in ...