Author | Nyce, Jonathan W. | |
Date Accessioned | 2019-12-02T15:42:16Z | |
Date Available | 2019-12-02T15:42:16Z | |
Date of Issue | 1996-04-18 | |
Identifier (Other) | International Publication # WO1996011280A1 | |
Identifier (URI) | http://hdl.handle.net/10342/7558 | |
Description | Disclosed are attenuated viruses, not naturally occurring, that contain one or more additional methylation sites in the genome of the virus compared to the corresponding wild-type virus. Preferably, the methylation sites are added into the genome of the virus by introducing an additional CG segment into the genome by means of a silent mutation. The attenuated viruses are useful for producing an immune response, including both the production of antibodies in animals for diagnostic use and the induction of protective immunity in a subject. Pharmaceutical formulations and methods of making the attenuated viruses are also disclosed. | en_US |
Language | en_US | en_US |
Related URI | https://patents.google.com/patent/WO1996011280A1/en?oq=inassignee:%22East+Carolina%22 | en_US |
Subject | virology | en_US |
Subject | modification | en_US |
Subject | immunology | en_US |
Title | Attenuated viruses and method of making the same | en_US |
Type | Patent | en_US |