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Now showing items 1937-1956 of 10631
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Comprehensive track-structure based evaluation of DNA damage by light ions from radiotherapy- relevant energies down to stopping
(2017-03-27)Track structures and resulting DNA damage in human cells have been simulated for hydrogen, helium, carbon, nitrogen, oxygen and neon ions with 0.25–256 MeV/u energy. The needed ion interaction cross sections have been ... -
Computational identification of microRNAs associated to both epithelial to mesenchymal transition and NGAL/MMP-9 pathways in bladder cancer
(2016-11-08)Bladder cancer is one of the leading cancer of the urinary tract. It is often diagnosed at advanced stage of the disease. To date, no specific and effective early detection biomarkers are available. Cancer development and ... -
Computational Investigation of Calcium Binding Proteins Annexin A1 and Cardiac Troponin C
(East Carolina University, 2019-07-15)Calcium binding proteins are vital for many biological functions. Many undergo calcium induced conformation changes through sensing motifs, resulting in functional changes for the proteins. In this study computational ... -
Computational Modeling of Arteriovenous Fistula Hemodynamics in Pulmonary Hypertension Patients
(East Carolina University, 2023-07-21)In the United States, approximately 50 million people suffer from chronic kidney disease, which over time progresses to end-stage renal disease (ESRD). Care for these patients is typically managed by dialysis with the ... -
Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer
(2016-03)Background Malignant melanoma is an aggressive tumor of the skin and seems to be resistant to current therapeutic approaches. Melanocytic transformation is thought to occur by sequential accumulation of genetic and ... -
Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer
(2016-03-25)Background Malignant melanoma is an aggressive tumor of the skin and seems to be resistant to current therapeutic approaches. Melanocytic transformation is thought to occur by sequential accu- mulation of genetic and ... -
COMPUTER SCIENCE STUDENTS AND LIBRARY TECHNOLOGY: EVALUATING STUDENTS’ CAREER GOALS TO CREATE STRATEGIES THAT INCREASE INTEREST IN LIBRARY EMPLOYMENT
(East Carolina University, 2021-12-03)Academic libraries in the United States often have difficulty recruiting for technology-focused positions. This mixed-methods study examines what technology skills libraries are seeking in entry-level technology positions ... -
Computer self-efficacy, anxiety, and learning in online versus face to face medium
(2012-01-01)The purpose of this research is to examine the relationships between changes to computer self-efficacy (CSE) and computer anxiety and the impact on performance on computer-related tasks in both online and face-to-face ... -
COMT Inhibition Alters Cue-Evoked Oscillatory Dynamics during Alcohol Drinking in the Rat
(2018-10-12)Alterations in the corticostriatal system have been implicated in numerous substance use disorders, including alcohol use disorder (AUD). Adaptations in this neural system are associated with enhanced drug-seeking behaviors ... -
The concept of essential use for determining when uses of PFASs can be phased out
(2019-05-27)Because of the extreme persistence of per- and polyfluoroalkyl substances (PFASs) and their associated risks, the Madrid Statement argues for stopping their use where they are deemed not essential or when safer alternatives ... -
Concerns toward hiring individuals with substance use disorders as compared to mental health disorders.
(East Carolina University, 2015)Individuals with Substance Use Disorders (SUDs) and Mental Health Disorders (MHDs) are among the highest stigmatized group for people with disabilities. Stigma associated with SUDs and MHDs influences disparate rates of ...