Browsing by Author "Ables, Elizabeth Tweedie"
-
Novel roles for ecdysone receptor in the Drosophila germline
Phipps, Daniel N (East Carolina University, 2022-07-01)Oogenesis, the process by which a viable egg is produced, demands carefully coordinated communication between somatic and germ cell populations, relying on both local and systemic factors such as steroid hormones for ... -
Novel roles for ecdysone receptor in the Drosophila germline
Phipps, Daniel Noah (East Carolina University, 2022-07-01)Oogenesis, the process by which a viable egg is produced, demands carefully coordinated communication between somatic and germ cell populations, relying on both local and systemic factors such as steroid hormones for ... -
NR5A family member ftz-f1 is necessary to promote oocyte development
McDonald, Samantha I (East Carolina University, 2019-07-15)Gamete production in mammals and insects is intimately tied to nutrition status. Conversion of nutritionally-dependent physiological signals to molecular mechanisms underlying control of oogenesis, however, remains largely ... -
Orphan Nuclear Receptor ftz-f1 (NR5A3) Promotes Egg Chamber Survival in the Drosophila Ovary
Ables, Elizabeth Tweedie; Beachum, Allison N.; Whitehead, Kaitlin M.; McDonald, Samantha I.; Phipps, Daniel N.; Berghout, Hanna E. (2021-01-23) -
Quantitative Analysis and Comparison of 3D Morphology Between Viable and Apoptotic MCF-7 Breast Cancer Cells and Characterization of Nuclear Fragmentation
Lu, Jun Qing; Chen, Zhan; Ables, Elizabeth Tweedie; Scemama, Jean-Luc; Yang, Li V.; Hu, Xin-Hua (2017-09-08) -
Quantitative analysis and comparison of 3D morphology between viable and apoptotic MCF-7 breast cancer cells and characterization of nuclear fragmentation
Wen, Yuhua; Chen, Zhan; Lu, Jianfen; Ables, Elizabeth Tweedie; Scemama, Jean-Luc; Yang, Li V.; Lu, Jun Q.; Hu, Xin-Hua (2017-09-08)Morphological changes in apoptotic cells provide essential markers for defining and detec- tion of apoptosis as a fundamental mechanism of cell death. Among these changes, the nuclear fragmentation and condensation have ... -
Quantitative analysis and comparison of 3D morphology between viable and apoptotic MCF-7 breast cancer cells and characterization of nuclear fragmentation
Wen, Yuhua; Chen, Zhan; Lu, Jianfen; Ables, Elizabeth Tweedie; Scemama, Jean-Luc; Yang, Liv. V.; Lu, Jun Q.; Hu, Xin-Hua (2017-09-08)Morphological changes in apoptotic cells provide essential markers for defining and detection of apoptosis as a fundamental mechanism of cell death. Among these changes, the nuclear fragmentation and condensation have ... -
Somatic steroid hormone signaling promotes early oocyte polarization in Drosophila
Whitehead, Kaitlin M (East Carolina University, 2021-07-28)In the ovary, oogenesis depends on intercellular communication between somatic and germ cell populations for proper oocyte production. Steroid hormone signaling, well-described for its diverse roles throughout oogenesis, ... -
Spargel/dPGC-1 is essential for oogenesis and nutrient-mediated ovarian growth in Drosophila
Basar, Mohammed Abul; Williamson, Kishana; Roy, Swagota D.; Danielle S., Finger; Ables, Elizabeth Tweedie; Duttaroy, Atanu (2019-06-25)Dietary proteins are crucial for oogenesis. The Target of Rapamycin (TOR) is a major nutrient sensor controlling organismal growth and fertility, but the downstream effectors of TOR signaling remain largely uncharacterized. ... -
THE ROLE OF DROSOPHILA NUCLEAR RECEPTOR FTZ-F1 IN SOMATIC CELLS IS NECCESSARY FOR GERMLINE STEM CELL MAINTENANCE
Sanders, Sydney (East Carolina University, 2022-04-29)The production of gametes is a controlled synergistic relationship between germ cells and somatic cells. In Drosophila oogenesis, the NR5A subfamily nuclear receptor ftz-f1 is expressed in the germline stem cells, germ ... -
THE ROLE OF HNRNPS ON THE ESTABLISHMENT AND MAINTENANCE OF GERMLINE STEM CELLS IN DROSOPHILA MELANOGASTER
Holt, Vivian (East Carolina University, 2018-05-03)An organism’s ability to grow and regulate tissue repair relies on the stimulation of stem cells in response to changes in physiological state, such as cell damage, sexual maturation and growth. Tissue-resident stem cells ... -
The Role of Oatp74D, an Ecdysone Importer, in the Drosophila ovary.
Powell, Amanda M (East Carolina University, 2022-05-04)Oogenesis is the progression of germ cells through mitotic expansion, differentiation into an oocyte, and successful completion of meiosis. Steroid hormones play critical roles in this process in diverse organisms. In ... -
The Role of Pre-Replication Complex Proteins in Drosophila Ovarian Stem Cell Maintenance and Proliferation
Safin, Justin R (East Carolina University, 2017-05-05)Cancer stem cells (CSCs) may hold the key to advances in cancer research. Like adult tissue-specific stem cells, CSCs are able to self-renew and last a lifetime. These shared characteristics can thus be used to help learn ... -
The small GTPase Ran and β-importins Tnpo-SR and Cadmus promote ovarian cyst formation in Drosophila
Beachum, Allison N (East Carolina University, 2021-06-14)Germ cells follow a precise and coordinated molecular timeline to produce a viable oocyte. While undergoing mitotic expansion via incomplete cytokinesis, cysts of undifferentiated cells form and remain interconnected prior ...