Browsing by Author "Houmard, Joseph A."
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Effects of Parental Obesity on Fat Metabolism During Submaximal Exercise in Children
Eaves, Audrey D. (East Carolina University, 2009)The aim of the present study was to compare fat metabolism during submaximal exercise in children with a morbidly obese parent - (COP) (BMI [greater than or equal to] 40 kg/m²) to children with relatively lean parents - ... -
Effects of resveratrol and contractile activity in human skeletal muscle myotubes from severely obese individuals
Park, Sanghee (East Carolina University, 2016-07-25)The prevalence of obesity is exponentially increasing worldwide. Although strategies such as exercise, nutritional intervention, and pharmaceutical therapies including resveratrol have been extensively studied in lean or ... -
ENHANCED INSULIN SIGNALING FOLLOWING CONTRACTILE ACTIVITY IS BLUNTED IN MYOTUBES FROM SEVERELY OBESE INDIVIDUALS WITH OR WITHOUT TYPE 2 DIABETES
Lim, Seongkyun (East Carolina University, 2018-06-11)Introduction: Regular exercise has been known to improve insulin sensitivity in obese/ Type 2 Diabetic (T2D) individuals. However, some obese and T2D individuals do not respond well to regular exercise in their metabolic ... -
Exercise Training Amount and Intensity Effects on Metabolic Syndrome (From Studies of a Targeted Risk Reduction Intervention through Defined Exercise)
Johnson, Johanna L.; Slentz, Cris A.; Houmard, Joseph A.; Samsa, Gregory P.; Duscha, Brian D.; Aiken, Lori B.; McCartney, Jennifer S.; Tanner, Charles J.; Kraus, William E. (East Carolina University, 2007-12-15)Although exercise improves individual risk factors of the metabolic syndrome (MS), there is little research on the effect of exercise on MS as a whole. The objective of this study was to determine how much exercise is ... -
Genetic Characterization of Physical Activity Behaviours in University Students Enrolled in Kinesiology Degree Programs
Houmard, Joseph A. (2017-03-01) -
Genetic Variation in Acid Ceramidase Predicts Non-Completion of an Exercise Intervention
Houmard, Joseph A. (2018-06-29) -
High-intensity exercise to promote accelerated improvements in cardiorespiratory fitness (HI-PACE): study protocol for a randomized controlled trial
McGee, Joshua E.; Barefoot, Savanna G.; Gniewek, Nicole R.; Brophy, Patricia; Clark, Angela; Dubis, Gabriel S.; Ryan, Terence E.; Houmard, Joseph A.; Vos, Paul; Raedeke, Thomas D.; Swift, Damon L. (2019-08-08)Background: African Americans have a disproportionate prevalence and incidence of type 2 diabetes compared with Caucasians. Recent evidence indicates that low cardiorespiratory fitness (CRF) level, an independent risk ... -
The impact of a repeated bout of eccentric exercise on muscular strength, muscle soreness and creatine kinase.
Smith, L. L.; Fulmer, M. G.; Holbert, Donald; McCammon, Michael R.; Houmard, Joseph A.; Frazer, D. D.; Nsien, E.; Israel, R. Gay (East Carolina University, 1994-12)The purpose of this study was to determine if there were any beneficial or detrimental effects regarding delayed onset muscle soreness (DOMS), serum creatine kinase (CK), and maximum concentric strength at 80% of 1-RMconc, ... -
Impact of Hormone Replacement Therapy on Exercise Training-Induced Improvements in Insulin Action in Sedentary Overweight Adults
Huffman, Kim M.; Slentz, Cris A.; Johnson, Johanna L.; Samsa, Gregory P.; Duscha, Brian D.; Tanner, Charles J.; Annex, Brian H.; Houmard, Joseph A.; Kraus, William E. (East Carolina University, 2008-07)Exercise training (ET) and hormone replacement therapy (HRT) are both recognized influences on insulin action, but the influence of HRT on responses to ET has not been examined. In order to determine if HRT use provided ... -
Impairments in Site-Specific AS160 Phosphorylation and Effects of Exercise Training
Consitt, Leslie A.; Van Meter, Jessica; Newton, Christopher A.; Collier, David N.; Dar, Moahad S.; Wojtaszewski, Jørgen F.P.; Treebak, Jonas T.; Tanner, Charles J.; Houmard, Joseph A. (2013-10) -
Increased Secretion and Expression of Myostatin in Skeletal Muscle From Extremely Obese Women
Hittel, Dustin S.; Berggren, Jason R.; Shearer, Jane; Boyle, Kristen E.; Houmard, Joseph A. (East Carolina University, 2009-01)OBJECTIVE- Obesity is associated with endocrine abnormalities that predict the progression of insulin resistance to type 2 diabetes. Because skeletal muscle has been shown to secrete proteins that could be used as biomarkers, ... -
Infant Mesenchymal Stem Cell Insulin Action Is Associated With Maternal Plasma Free Fatty Acids, Independent of Obesity Status: The Healthy Start Study
Chaves, Alec B.; Zheng, Donghai; Johnson, Jonathan A.; Biagioni, Ericka M.; Krassovskaia, Polina; Broskey, Nicholas T.; May, Linda E.; Houmard, Joseph A. (2022-08) -
The Influence of Maternal Aerobic Exercise, Blood DHA and EPA Concentrations on Maternal Lipid Profiles
Kew, Kimberly A.; Houmard, Joseph A.; Tulis, David A.; Pawlak, Roman; Newton, Edward; May, Linda E. (2022-03-16) -
Insulin Stimulated Lactate Production
Griffin, Jordan (2014)It has been shown that Type 2 diabetic patients who undergo Roux-en-Y Gastric Bypass surgery (RYGB) show a decrease in muscle lactate production, liver glucose production and pancreatic insulin secretion. To explain these ... -
INTERLEUKIN-6 IN RESPONSE TO HIGH INTENSITY AND MODERATE INTENSITY EXERCISE TRAINING IN AFRICAN AMERICAN INDIVIDUALS
Krassovskaia, Polina (East Carolina University, 8/5/2020)Skeletal muscle has been identified as an endocrine organ that releases myokines with contraction. These myokines have been defined as cytokines and peptides that are produced, expressed, and released by muscle fibers that ... -
Intramuscular Lipid Metabolism, Insulin Action and Obesity
Consitt, Leslie A.; Bell, Jill A.; Houmard, Joseph A. (East Carolina University, 2009-01)With the increasing prevalence of obesity, research has focused on the molecular mechanism(s) linking obesity and skeletal muscle insulin resistance. Metabolic alterations within muscle, such as changes in the cellular ... -
Intramuscular lipid oxidation and obesity
Houmard, Joseph A. (East Carolina University, 2008-04)There is an accumulating amount of evidence indicating that lipid oxidation is depressed in the skeletal muscle of obese individuals. Decrements in fatty acid oxidation (FAO) have been reported with obesity in models ranging ... -
Is there a metabolic program in the skeletal muscle of obese individuals?
Houmard, Joseph A.; Pories, Walter J.; Dohm, G. Lynis (2011-04-26)Severe obesity (BMI ≥ 40 kg/m2) is associated with multiple defects in skeletal muscle which contribute to insulin resistance and a reduction in fatty acid oxidation (FAO) in this tissue. These metabolic derangements are ...