Browsing by Author "Lu, Qun"
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Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover
Kim, Jin-Sook; Bareiss, Sonja; Kim, Kyung Keun; Tatum, Rodney; Han, Jeong-Ran; Jin, Yun Hye; Kim, Hangun; Lu, Qun; Kim, Kwonseop (East Carolina University, 2006-12-29)Although delta-catenin/neural plakophilin-related armadillo protein (NPRAP) was reported to interact with presenilin-1 (PS-1), the effects of PS-1 on delta-catenin have not been established. In this study, we report that ... -
Rho GTPases as therapeutic targets in Alzheimer’s disease
Aguilar, Byron J.; Zhu, Yi; Lu, Qun (2017-12-15)The progress we have made in understanding Alzheimer’s disease (AD) pathogenesis has led to the identification of several novel pathways and potential therapeutic targets. Rho GTPases have been implicated as critical ... -
Small Molecule, Non-Peptide p75NTR Ligands Inhibit Aß-Induced Neurodegeneration and Synaptic Impairment
Yang, Tao; Knowles, Juliet K.; Lu, Qun; Zhang, Hong; Arancio, Ottavio; Moore, Laura A.; Chang, Timothy; Wang, Qian; Andreasson, Katrin; Rajadas, Jayakumar; Fuller, Gerald G.; Xie, Youmei; Massa, Stephen M.; Longo, Frank M. (East Carolina University, 2008-11-03)The p75 neurotrophin receptor (p75NTR) is expressed by neurons particularly vulnerable in Alzheimer’s disease (AD). We tested the hypothesis that non-peptide, small molecule p75NTR ligands found to promote survival signaling ... -
SPATIAL AND PLANAR DYSREGULATION OF RHOGTPASES IN HUMAN AND ALZHEIMER’S DISEASE MOUSE MODEL
Nik Akhtar, Shayan (East Carolina University, 2023-11-27)Rho proteins belong to the Ras superfamily of small GTPases. In humans, the Rho family of GTPases contains 20 members out of which the most studied Rho proteins are RhoA, Rac1, and Cdc42. Rho signaling is known to regulate ... -
THE THERAPEUTIC EFFECT OF RHO KINASE INHIBITOR Y-27632 ON PROTECTION FROM CHEMOTHERAPY INDUCED PERIPHEAL NEUROPATHY IN MOUSE MODEL
Elliott, Zachary (East Carolina University, 2018-05-01)Chemotherapy drugs have neurotoxicity associated with treatment, which can become a dose-limiting problem when clinical presentation is severe. However, there is no effective therapy to circumvent the neurotoxicity of ... -
THE THERAPEUTIC ROLE OF RHO GTPASES IN TUMORIGENESIS AND CHEMOTHEARPY-INDUCED PERIPHERAL NEUROPATHY
Zhu, Yi (East Carolina University, 2019-07-15)With the advancement of chemotherapy drugs, the general life expectancy of cancer patients has drastically improved. However, persistent side effects, such as chemotherapy-induced peripheral neuropathy (CIPN), often severely ... -
The therapeutic potential of Rho GTPase intervention
Friesland, Amy Michelle (East Carolina University, 2013)Small GTPases of the Rho family are well established regulators of critical cellular functions including cytoskeletal remodeling, motility, vesicle trafficking and cell cycle control. Additionally, aberrant signaling ... -
VASP Activation via the Gα13/RhoA/PKA Pathway Mediates Cucurbitacin-B-Induced Actin Aggregation and Cofilin-Actin Rod Formation
Zhang, Yan-Ting; Xu, Li-Hui; Lu, Qun; Liu, Kun-Peng; Liu, Pei-Yan; Ji, Fang; Liu, Xiao-Ming; Ouyang, Dong-Yun; He, Xian-Hui (2014) -
VASP activation via the Gα13/RhoA/PKA pathway mediates cucurbitacin-B-induced actin aggregation and cofilin-actin rod formation
Zhang, Yan-Ting; Xu, Li-Hui; Lu, Qun; Liu, Kun-Peng; Liu, Pei-Yan; Ji, Fang; Liu, Xiao-Ming; Ouyang, Dong-Yun; He, Xian-Hui (2014-04-01)Cucurbitacin B (CuB), a potent antineoplastic agent of cucurbitacin triterpenoids, induces rapid disruption of actin cytoskeleton and aberrant cell cycle inhibiting carcinogenesis. However, the underlying molecular mechanism ...