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Now showing items 5223-5242 of 10630
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Inhibition of CD44 intracellular domain production suppresses bovine articular chondrocyte de-differentiation induced by excessive mechanical stress loading
(2019-10-17)CD44 fragmentation is enhanced in chondrocytes of osteoarthritis (OA) patients. We hypothesized that mechanical stress-induced enhancement of CD44-intracellular domain (CD44-ICD) production plays an important role in the ... -
Inhibition of Cdk2 activity decreases Aurora-A kinase centrosomal localization and prevents centrosome amplification in breast cancer cells
(2013-05)Centrosome amplification plays a key role in the origin of chromosomal instability (CIN) during cancer development and progression. In this study, MCF-7 breast cancer cell lines harboring abrogated p53 function (vMCF-7DNp53) ... -
Inhibition of Cdk2 kinase activity selectively targets the CD44/CD24 stem-like subpopulation and restores chemosensitivity of SUM149PT triple-negative breast cancer cells
(2014-09)Inflammatory breast cancer (IBC) is an angioinvasive and most aggressive type of advanced breast cancer characterized by rapid proliferation, chemoresistance, early metastatic development and poor prognosis. IBC tumors ... -
The inhibition of CHO-K1-BH4 cell proliferation and induction of chromosomal aberrations by brevetoxins in vitro
(East Carolina University, 2006-07)Brevetoxins (PbTxs) are highly potent trans-syn polyether neurotoxins produced during blooms of several species of marine dinoflagellates, most notably Karenia brevis. These neurotoxins act on voltage-sensitive sodium ... -
Inhibition of contraction and myosin light chain phosphorylation in guinea-pig smooth muscle by p21-activated kinase 1
(East Carolina University, 2003-06-01)The p21-activated protein kinases (PAKs) have been implicated in cytoskeletal rearrangements and modulation of non-muscle contractility. Little, however, is known about the role of the PAK family members in smooth muscle ... -
Inhibition of histone acetyltransferase (HAT) activity by HBZ extends beyond the p300/CBP HAT family
(2014)We previously reported that HTLV-1 basic leucine zipper factor (HBZ) interacts with the cellular coactivator p300 in cells derived from ATL patients. We further determined that HBZ directly binds to the histone acetyltransferase ... -
Inhibition of Nischarin Expression Attenuates Rilmenidine-Evoked Hypotension and Phosphorylated Extracellular Signal-Regulated Kinase 1/2 Production in the Rostral Ventrolateral Medulla of Rats
(East Carolina University, 2008-01)Imidazoline (I1)-evoked hypotension is linked to enhanced phosphorylated extracellular signalregulated kinase (pERK)1/2 production in the rostral ventrolateral medulla (RVLM). Recent cell culture findings suggest that ... -
Inhibition of Quorum Sensing by a Pseudomonas aeruginosa dksA Homologue
(East Carolina University, 2001-03)The Pseudomonas aeruginosa las (lasR-lasI) and rhl (rhlR-rhlI) quorum-sensing systems regulate the expression of several virulence factors, including elastase and rhamnolipid. P. aeruginosa strain PR1-E4 is a lasR deletion ... -
Inhibition of Stuttering from Second Speech Signals: An Evaluation of Temporal and Hierarchical Aspects
(East Carolina University, 2012)Stuttering is an intermittent and involuntary speech disorder overtly characterized by syllable repetitions, phoneme prolongations and postural fixations that disrupt the natural flow of speech. Overt stuttering is reduced ... -
Inhibition of vascular smooth muscle growth via signaling crosstalk between AMP-activated protein kinase and cAMP-dependent protein kinase
(2012-10)Abnormal vascular smooth muscle (VSM) growth is central in the pathophysiology of vascular disease yet fully effective therapies to curb this growth are lacking. Recent findings from our lab and others support growth control ... -
Inhibition of vascular smooth muscle growth via signaling crosstalk between amp-activated protein kinase and camp-dependent protein kinase
(2012-10-29)Abnormal vascular smooth muscle (VSM) growth is central in the pathophysiology of vascular disease yet fully effective therapies to curb this growth are lacking. Recent findings from our lab and others support growth control ... -
Inhibitory and oxidative effects of gossypol on MCF7 Breast Cancer cells in vitro
(East Carolina University, 2013)Human cancer is the second leading cause of death in the United States and breast cancer is responsible for the second highest number of deaths in women with cancer worldwide. Today, cancer is becoming more and more ... -
Inhouse Call Business Plan
(East Carolina University, 2023-04-26)InHouse Call is an information directory app that can be used to facilitate smooth communication between medical providers and other staff that are part of the healthcare team by eliminating call transfers within an ... -
Iniquities
(East Carolina University, 2015)This thesis is a representative collection of short stories that I have written as part of my Master's requirements. The four pieces included demonstrate the overarching style, length, and major themes of much of my recent ... -
Initial Characterization of the FlgE Hook High Molecular Weight Complex of
(2014)The spirochete periplasmic flagellum has many unique attributes. One unusual characteristic is the flagellar hook. This structure serves as a universal joint coupling rotation of the membrane-bound motor to the flagellar ... -
Initiating Practice Guidelines for Postpartum Depression Screening at Well-Child Visits
(2014-11-21)Purpose: This project examined the process of initiating postpartum depression (PPD) screening via a PPD protocol at 2 month well-child visit in four pediatric/family practice offices in a rural North Carolina county. The ... -
Initiating Vital Signs in an Outpatient Physical Therapy Practice: Incorporating Interprofessional Care
(2020-04-17)This DNP project implemented vital sign screenings at a physical therapy clinic prior to starting physical therapy, based on the Guide to Physical Therapy Practice recommendation. The literature review showed that many ... -
Injuries of the mind, body, and soul : an exploration of moral injury among military service members and veterans
(East Carolina University, 2020-11-16)Military service often requires engaging in activities, witnessing acts, or immediate decision-making that may violate the moral codes and personal values to which most individuals ascribe. If unacknowledged, these factors ...