Browsing by Author "Akula, Shaw M."
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A role for VEGFRs in regulating KSHV latency
Lambert, Phelps J. -
A Smad3/FoxO3 Transcriptional Relationship in the Regulation of Vascular Growth
Francisco, Jake (East Carolina University, 2019-06-05)Cardiovascular disease (CVD) is a multi-faceted pathological condition that continually ranks as the number one cause of morbidity and mortality in the United States and worldwide. Unfortunately, despite extensive basic ... -
Cellular miR-150-5p May Have a Crucial Role to Play in the Biology of SARS-CoV-2 Infection by Regulating nsp10 Gene
Akula, Shaw M.; Bolin, Paul; Cook, Paul P. (2022) -
Changes occuring [sic] on the cell surface during KSHV reactivation
Whitman, Audy G. -
Cigarette smoking abrogates angiogenesis :implications for Kaposi's sarcoma
Bryan, Benjamin A. -
Cigarette smoking abrogates angiogenesis :implications for Kaposi's sarcoma
Bryan, Benjamin A. -
COVID-19 Infection Enhances Susceptibility to OxidativeStress–Induced Parkinsonism
Eells, Jeffrey B.; Akula, Shaw M.; Sriramula, Srinivas; O’Rourke, Dorcas P.; Smeyne, Richard J.; et al (2022-06-09) -
DEFINING THE ABILITY OF SNAT NANOTHERAPEUTIC TO INHIBIT SARS-COV-2 INFECTION AND ALTER THE HOST MICRONOME TO INDUCE AN ANTIVIRAL CELLULAR ENVIRONMENT
Bauer, Anais (East Carolina University, 2023-12-07)MicroRNAs (miRNAs) are regulatory elements that canonically bind to target mRNAs, reducing translation and protein output. They are non-coding strands of RNA, roughly 18-25 nucleotides long, and are found in plants, animals, ... -
Differential regulation of the attachment of KSHV infected human B cells to ECM by KSHV encoded gB and cellular alpha-V integrins
Dyson, Ossie F.; Oxendine, Telisha L.; Hamden, Khalief E.; Ford, Patrick W.; Akula, Shaw M. (East Carolina University, 2008-07)Kaposi’s sarcoma-associated herpesvirus (KSHV) has two modes replication: latent and lytic replication. Reactivation from latency is dictated, in part, by the cell cycle. Herein, we have attempted to delineate the importance ... -
DISINTEGRIN-LIKE DOMAIN IN KSHV ENCODED gB IS A NECESSITY TO PROMOTE VIRUS LATENCY
Walker, Lia R. (East Carolina University, 2011)KSHV glycoprotein B (gB) is a lytic structural protein expressed on the envelope of mature virions and on the membrane of cells supporting lytic infection. Previous studies have identified that in addition to the role of ... -
Effects of the Mutant TP53 Reactivator APR-246 on Therapeutic Sensitivity of Pancreatic Cancer Cells in the Presence and Absence of WT-TP53
Abrams, Stephen L.; Akula, Shaw M.; Steelman, Linda S.; McCubrey, James A. (2022-02-24) -
FUNCTION OF DISINTEGRIN-LIKE DOMAIN OF KSHV gB IN REGULATING VIRUS INFECTION
Walker, Lia R. (East Carolina University, 2015-12-10)KSHV, also referred to as human herpesvirus-8 (HHV-8), is the eighth and latest identified human herpesvirus. It is the causative agent for a variety of malignancies namely Kaposi’s sarcoma (KS), primary effusion lymphoma ... -
GSK-3β Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals
Abrams, Stephen L.; Akula, Shaw M.; Meher, Akshaya K.; Steelman, Linda S.; Gizak, Agnieszka; Duda, Przemysław; Rakus, Dariusz; Martelli, Alberto M.; Ratti, Stefano; Cocco, Lucio; Montalto, Giuseppe; Cervello, Melchiorre; Ruvolo, Peter; Libra, Massimo; Falzone, Luca; Candido, Saverio; McCubrey, James A. (2021-04) -
KSHV gB associated RGD interactions promote attachment of cells by inhibiting the potential migratory signals induced by the disintegrin-like domain
Hussein, Hosni Ahmed Mohamed; Walker, Lia R.; Akula, Shaw M. (2016-02)Background: Kaposi's sarcoma-associated herpesvirus (KSHV) glycoprotein B (gB) is not only expressed on the envelope of mature virions but also on the surfaces of cells undergoing lytic replication. Among herpesviruses, ... -
KSHV gB associated RGD interactions promote attachment of cells by inhibiting the potential migratory signals induced by the disintegrin-like domain
Hussein, Hosni; Walker, Lia; Akula, Shaw M. (2016-02-24)Background: Kaposi’s sarcoma-associated herpesvirus (KSHV) glycoprotein B (gB) is not only expressed on the envelope of mature virions but also on the surfaces of cells undergoing lytic replication. Among herpesviruses, KSHV ... -
MICRONOME AND KSHV INFECTION: IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF CELLULAR MICRORNAS DURING VIRUS ENTRY
Hussein, Hosni Ahmed Mohamed (East Carolina University, 2018-04-17)Kaposi's sarcoma-associated herpesvirus (KSHV), is the most recently identified human herpesvirus and causes a variety of human malignancies. KSHV is etiologically associated with Kaposi's sarcoma (KS), primary effusion ... -
miRNA-36 inhibits KSHV, EBV, HSV-2 infection of cells via stifling expression of interferon induced transmembrane protein 1 (IFITM1)
Hussein, Hosni A. M.; Akula, Shaw M. (2017-12-21)Kaposi’s sarcoma-associated herpesvirus (KSHV) is etiologically associated with all forms of Kaposi’s sarcoma worldwide. Little is currently known about the role of microRNAs (miRNAs) in KSHV entry. We recently demonstrated ... -
Novel Nano-Based Antibacterial Therapeutic Against Hospital Acquired Infection
Williams, Jordan E (East Carolina University, 2022-07-19)Rising nosocomial infections, also called hospital-acquired infections (HAIs), are of imminent public health concern as common antibiotics, such as ampicillin and kanamycin, are becoming less effective against bacterial ...