Browsing by Author "Cha, Dong Seok"
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Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in
Seo, Hyun Won; Cheon, Se-Myeong; Lee, Myon-Hee; Kim, Hong Jun; Jeon, Hoon; Cha, Dong Seok (2015)Catalpol is an effective component of rehmannia root and known to possess various pharmacological properties. The present study was aimed at investigating the potential effects of catalpol on the lifespan and stress tolerance ... -
MPK-1/ERK is required for the full activity of resveratrol in extended lifespan and reproduction.
Yoon, Dong Suk; Cha, Dong Seok; Choi, Yoorim; Lee, Jin Woo; Lee, Myon‐Hee (2018-12-21)Resveratrol (RSV) extends the lifespan of various organisms through activation of sirtuin. However, whether RSV-mediated longevity is entirely dependent upon sirtuin is still controversial. Thus, understanding additional ... -
Sorbus alnifolia protects dopaminergic neurodegeneration in Caenorhabditis elegans
Cheon, Se-Myeong; Jang, Insoo; Lee, Myon-Hee; Kim, Dae Keun; Jeon, Hoon; Cha, Dong Seok (2017-01)Context: The twigs of Sorbus alnifolia (Sieb. et Zucc.) K. Koch (Rosaceae) have been used to treat neuro- logical disorders as a traditional medicine in Korea. However, there are limited data describing the efficacy of S. ... -
Subunits of the DNA Oolymerase Alpha-Primase Complex Promote Notch-Mediated Proliferation with Discrete and Shared Functions in C. elegans Germline
Lee, Myon Hee; Yoon, Dong Suk; Cha, Dong Seok; Alfhili, Mohammad A.; Keiper, Brett D. (2018-05-28) -
A systematic mRNA control mechanism for germline stem cell homeostasis and cell fate specification
Lee, Myon-Hee; Mamillapalli, Srivalli Swathi; Keiper, Brett D.; Cha, Dong Seok (2016-02)Germline stem cells (GSCs) are the best understood adult stem cell types in the nematode Caenorhabditis elegans, and have provided an important model system for studying stem cells and their cell fate in vivo, in mammals. ... -
Triclosan Disrupts SKN-1/Nrf2- Mediated Oxidative Stress Response in C. elegans and Human Mesenchymal Stem Cells
Yoon, Dong Suk; Choi, Yoorim; Cha, Dong Seok; Zhang, Peng; Choi, Seong Mi; Alfhili, Mohammad A.; Polli, Joseph Ryan; Pendergrass, DeQwon; Taki, Faten A.; Kapalavavi, Brahmam; Pan, Xiaoping; Zhang, Baohong; Blackwell, T. Keith; Lee, Jin Woo; Lee, Myon-Hee (2017-10-03)Triclosan (TCS), an antimicrobial chemical with potential endocrine-disrupting properties, may pose a risk to early embryonic development and cellular homeostasis during adulthood. Here, we show that TCS induces toxicity ...