Browsing by Author "Geyer, Christopher B."
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Advanced immunostaining approaches to study early male germ cell development
Niedenberger, Bryan A.; Geyer, Christopher B. (2018-02-09)Mammalian male germ cell development takes place in the testis under the influence of a variety of somatic cells and an incompletely defined paracrine and endocrine influences. Since it is not recapitulated well in vitro, ... -
ANALYSIS OF TRANSGENIC MOUSE MODELS TO STUDY MAMMALIAN SPERMATOGONIA
Kirsanov, Oleksandr (East Carolina University, 2018-07-24)Spermatogenesis in the mammalian testis results in the daily production of millions of spermatozoa. This developmental process is founded upon the actions of a small population of spermatogonial stem cells (SSCs). As SSCs ... -
Androgen Signaling Promotes Translation of in Prostate Cancer Cells via Phosphorylation of the α Subunit of the Translation Initiation Factor 2
Overcash, Ryan Franklin; Chappell, Vesna A.; Green, Thomas D.; Geyer, Christopher B.; Asch, Adam S.; Ruiz-Echevarría, Maria J. (2013) -
The Germ Cell-Specific RNA Binding Protein RBM46 is Essential for Spermatogonial Differentiation in Mice
Johnson, Taylor A.; Geyer, Christopher B. (2022-09-21) -
The Mammalian Spermatogenesis Single-Cell Transcriptome, from Spermatogonial Stem Cells to Spermatids
Hermann, Brian P.; Cheng, Keren; Singh, Anukriti; Roa-De La Cruz, Lorena; Mutoji, Kazadi N.; Chen, I-Chung; Gildersleeve, Heidi; Lehle, Jake D.; Mayo, Max; Westernstroer, Birgit; Law, Nathan C.; Oatley, Melissa J.; Velte, Ellen K.; Niedenberger, Bryan A.; Fritze, Danielle; Silber, Sherman; Geyer, Christopher B.; Oatley, Jon M.; McCarrey, John R. (2018-11-06)Spermatogenesis is a complex and dynamic cellular differentiation process critical to male reproduc- tion and sustained by spermatogonial stem cells (SSCs). Although patterns of gene expression have been described for ... -
Mammalian SWI/SNF Chromatin Remodeler is Essential for Reductional Meiosis in Males
Kirsanov, Oleksandr; Geyer, Christopher B.; Magnuson, Terry; Menon, Debashish U. (2021-11-12) -
Modeling Mammalian Spermatogonial Differentiation and Meiotic Initiation in Vitro
Kirsanov, Oleksandr; Johnson, Taylor; Malachowski, Taylor; Niedenberger, Bryan A.; Gilber, Emma A.; Geyer, Christopher B.; Fisher-Wellman, Kelsey; et al (2022) -
The Role of Retinoic Acid (RA) in Spermatogonial Differentiation
Busada, Jonathan T.; Geyer, Christopher B. (2016)Retinoic acid (RA) directs the sequential, but distinct, programs of spermatogonial differentiation and meiotic differentiation that are both essential for the generation of functional spermatozoa. These processes are ... -
THE ROLE OF RETINOIC ACID IN DIRECTING INITIATION OF SPERMATOGENESIS IN THE MOUSE
Busada, Jonathan T. (East Carolina University, 2015-10-23)The basic tenets of gametogenesis are conserved among metazoans. After lineage commitment, germ cells proliferate, complete meiosis, and then differentiate into gametes capable of fertilization. In the mouse, spermatogenesis ...