Browsing by Author "Huang, Hu"
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ACUTE HIGH INTENSITY TREADMILL EXERCISE INCREASES APPETITE AND NPY/AgRP AND TH NEURON ACTIVITY IN UNTRAINED FEMALE MICE
Free, Katrina (East Carolina University, 2021-05-28)Acute High and Moderate Intensity Treadmill Exercise Increases Appetite and NPY/AgRP and TH Neuron Activity in Untrained Female Mice Background: Exercise is commonly prescribed as a means for weight loss, however, ... -
Adaptations of the Hypothalamic Arcuate Nucleus in Response to Exercise and Hunger
Laing, Brenton (East Carolina University, 2018-05-02)The arcuate nucleus of the hypothalamus serves as a critical node for regulation of mammalian energy balance with the ability to sense the status of many organ systems and exert control over effector arms that potently ... -
Administration of alpha klotho reduces liver and adipose lipid accumulation in obese mice
Rao, Zhijian; Landry, Taylor; Li, Peixin; Bunner, Wyatt; Laing, Brenton Thomas; Yuan, Yuan; Huang, Hu (2019-04-05)α-Klotho, a known anti-aging protein, exerts diverse physiological effects including: maintenance of phosphate and calcium homeostasis, modulation of cell proliferation, and enhanced buffering of reactive oxygen species. ... -
AgRP neuron activity is required for acute exercise-induced feeding
Bunner, Wyatt (East Carolina University, 2019-08-13)While much is known about the role of neuropeptide Y/agouti-regulated peptide (NPY/AgRP) and pro-opiomelanocortin (POMC) neurons to regulate energy homeostasis, little is known about how forced energy expenditure, such as ... -
AgRP/NPY Neuron Excitability Is Modulated by Metabotropic Glutamate Receptor 1 During Fasting
Laing, Brenton Thomas; McClung, Joseph M.; Li, Peixin; Schmidt, Cameron Alan; Bunner, Wyatt; Yuan, Yuan; Landry, Taylor; Prete, Amber; Huang, Hu (2018-09-03) -
Antisense oligonucleotide and thyroid hormone conjugates for obesity treatment
Cao, Yang; Matsubara, Tomoko; Zhao, Can; Gao, Wei; Peng, Linxiu; Shan, Jinjun; Liu, Zhengxia; Yuan, Fang; Tang, Lingyi; Li, Peixin; Guan, Zhibin; Fang, Zhuyuan; Lu, Xiang; Huang, Hu; Yang, Qin (2017-08-24)Using the principle of antibody-drug conjugates that deliver highly potent cytotoxic agents to cancer cells for cancer therapy, we here report the synthesis of antisense-oligonucleotides (ASO) and thyroid hormone T3 ... -
Central α-Klotho is a Novel Regulator of Arcuate Neurons and Peripheral Metabolism
Landry, Taylor (East Carolina University, 2021-04-20)The arcuate nucleus of the hypothalamus (ARC) is a critical nexus of neuron populations that interpret peripheral signals of energy status and deliver diverse efferent outputs to metabolically active tissues. These neurons ... -
Centrally Circulating α-klotho Inversely Correlates with Human Obesity and Modulates Arcuate Cell Populations in Mice
Huang, Hu; Shookster, Daniel; Landry, Taylor; Li, Peixin; Jiang, Zhiying; Li, Hongli; Laing, Brenton Thomas; Bunner, Wyatt; Langton, Theodore; Tong, Qingchun (2021) -
Early Metabolic Differences in Alzheimer’s Disease Mouse Model and Exercise Intervention Treatment
Do, Khoa (East Carolina University, 2017-06-22)Alzheimer's disease (AD) is a neurodegenerative disorder that affects the central nervous system (CNS). In this study, we characterized and examined the early metabolic changes of the triple transgenic Alzheimer's disease ... -
The effects of exercise on hypothalamic neurodegeneration of Alzheimer’s disease mouse model
Do, Khoa; Laing, Brenton Thomas; Landry, Taylor; Bunner, Wyatt; Mersaud, Naderi; Matsubara, Tomoko; Li, Peixin; Yuan, Yuan; Lu, Qun; Huang, Hu (2018-01-02)Alzheimer’s disease is a neurodegenerative disorder that affects the central nervous sys- tem. In this study, we characterized and examined the early metabolic changes in the triple transgenic mouse AD model (3xtg-AD), and ... -
Energy Status Differentially Modifies Feeding Behavior and POMCARC Neuron Activity After Acute Treadmill Exercise in Untrained Mice
Landry, Taylor; Shookster, Daniel; Chaves, Alec B.; Free, Katrina; Nguyen, Tony; Huang, Hu (2021-06-18) -
Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood
Lee, Seung-Hwan; Zabolotny, Janice; Huang, Hu; Lee, Hyon; Kim, Young-Bum (2016)Background: Insulin, a pleotrophic hormone, has diverse effects in the body. Recent work has highlighted the important role of insulin's action in the nervous system on glucose and energy homeostasis, memory, and mood. ... -
α-Klotho Expression in Mouse Tissues Following Acute Exhaustive Exercise
Rao, Zhijian; Zheng, Lifang; Huang, Hu; Feng, Yu; Shi, Rengfei (2019-12-10)α-Klotho, a multifunctional protein, has been demonstrated to protect tissues from injury via anti-oxidation and anti-inflammatory effects. The expression of α-klotho is regulated by several physiological and pathological ...