Browsing by Author "Lemasson, Isabelle"
-
Direct Inhibition of RNAse T2 Expression by the HTLV-1 Viral Protein Tax
Polakowski, Nicholas; Han, Hongjin; Lemasson, Isabelle (2011-08)Adult T-cell leukemia (ATL) is one of the primary diseases caused by Human T-cell Leukemia Virus type 1 (HTLV-1) infection. The virally-encoded Tax protein is believed to initiate early events in the development of this ... -
Direct inhibition of RNAse T2 expression by the HTLV-1 viral protein Tax
Lemasson, Isabelle; Han, Hongjin; Polakowski, Nicholas (2011-08-18)Adult T-cell leukemia (ATL) is one of the primary diseases caused by Human T-cell Leukemia Virus type 1 (HTLV-1) infection. The virally-encoded Tax protein is believed to initiate early events in the development of this ... -
Expression of a protein involved in bone resorption, Dkk1, is activated by HTLV-1 bZIP factor through its activation domain
Polakowski, Nicholas; Gregory, Heather; Mesnard, Jean-Michel; Lemasson, Isabelle (2010)Background Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia, a malignancy characterized by uncontrolled proliferation of virally-infected CD4+ T-cells. Hypercalcemia and bone ... -
HBZ inhibits the HAT activity of the cellular coactivators p300 and CBP
Wright, Diana Grace; Wurm, Torsten; Polakowski, Nicholas; Mesnard, Jean-Michel; Lemasson, Isabelle (2011-) -
HTLV-1 basic leucine zipper factor protects cells from oxidative stress by upregulating expression of Heme Oxygenase I
Rushing, Amanda W; Rushing, Blake; Hoang, Kimson; Sanders, Stephanie V; Péloponèse, Jean-Marie; Polakowski, Nicholas; Lemasson, Isabelle (2019-06-28)Adult T-cell Leukemia (ATL) is a lymphoproliferative disease of CD4+ T-cells infected with Human T-cell Leukemia Virus type I (HTLV-1). With the exception of allogeneic hematopoietic stem cell transplantation, there are ... -
HTLV-1 Tax directly modulates expression of the CDK6 and RNASET2 genes
Polakowski, Nicholas; Han, Hongjin; Lemasson, Isabelle (2011) -
The HTLV-1-encoded protein HBZ directly inhibits the acetyl transferase activity of p300/CBP
Wurm, Torsten; Wright, Diana Grace; Polakowski, Nicholas; Mesnard, Jean-Michel; Lemasson, Isabelle (2012-07)The homologous cellular coactivators p300 and CBP contain intrinsic lysine acetyl transferase (termed HAT) activity. This activity is responsible for acetylation of several sites on the histones as well as modification of ... -
The HTLV-1-encoded protein HBZ directly inhibits the acetyl transferase activity of p300/CBP
Wurm, Torsten; Wright, Diana G.; Polakowski, Nicholas; Mesnard, Jean-Michel; Lemasson, Isabelle (2012-03-19)The homologous cellular coactivators p300 and CBP contain intrinsic lysine acetyl transferase (termed HAT) activity. This activity is responsible for acetylation of several sites on the histones as well as modification of ... -
Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Protein Interacts with the Cellular Transcription Factor CREB To Inhibit HTLV-1 Transcription
Lemasson, Isabelle; Lewis, Matthew R.; Polakowski, Nicholas; Hivin, Patrick; Cavanagh, Marie-Helene; Thebault, Sabine; Barbeau, Benoit; Nyborg, Jennifer K.; Mesnard, Jean-Michel (East Carolina University, 2007-02)The complex human T-cell leukemia virus type 1 (HTLV-1) retrovirus encodes several proteins that are unique to the virus within its 3 -end region. Among them, the viral transactivator Tax and posttranscriptional regulator ... -
Human T-cell Leukemia Virus Type 1 Basic Leucine Zipper Factor (HBZ) Interacts and Inhibits the Acetyltransferase Activity of Multiple Cellular Coactivator Families to Deregulate Transcription
Wright, Diana Grace (East Carolina University, 1/13/16)Of the 20 million individuals infected worldwide with the complex retrovirus, Human T-cell Leukemia Virus Type 1, 5% will develop an incurable and fatal form of leukemia known as adult T-cell leukemia (ATL). During the ... -
HUMAN T-CELL LEUKEMIA VIRUS TYPE 1-ENCODED PROTEIN HBZ INCREASES VIRAL INFECTION
Korleski, Erica (East Carolina University, 2017-05-04)Human T-lymphotropic virus type 1 (HTLV-1) is a complex retrovirus, infecting CD4+ T lymphocytes. About 10 million people worldwide are infected with HTLV-1. HTLV-1 has been linked to adult T-cell leukemia (ATL), a disease ... -
Human T-Cell Leukemia Virus Type I Basic Leucine Zipper Factor (HBZ) Modulates Cellular DNA Damage Repair and Antioxidant Responses to Promote Host Cell Survival and Leukemogenesis
Rushing, Amanda Williams (East Carolina University, 2018-04-19)Approximately twenty million people worldwide are infected with Human T-cell Leukemia Virus type 1 (HTLV-1). HTLV-1 establishes a life-long, chronic infection which can result in the development of severe HTLV-1 associated ... -
The Human T-cell Leukemia Virus type I basic leucine zipper factor upregulates the expression of the antioxidant Heme Oxygenase I,
Rushing, Amanda W.; Rushing, Blake; Hoang, Kimson; Péloponèse, Jean Marie; Polakowski, Nicholas; Lemasson, Isabelle (2019-04-01)Adult T-cell Leukemia/Lymphoma (ATLL) is a resilient lymphoproliferative disease of CD4+ T-cells infected by the Human T-cell Leukemia Virus type I (HTLV-1), for which there are no effective treatments. Mounting evidence ... -
Inhibition of histone acetyltransferase (HAT) activity by HBZ extends beyond the p300/CBP HAT family
Wright, Diana Grace; Polakowski, Nicholas; Lemasson, Isabelle (2014)We previously reported that HTLV-1 basic leucine zipper factor (HBZ) interacts with the cellular coactivator p300 in cells derived from ATL patients. We further determined that HBZ directly binds to the histone acetyltransferase ... -
INTERACTION BETWEEN HTLV-1 BASIC LEUCINE ZIPPER FACTOR (HBZ) AND HOST CELL PROTEINS PROMOTES CELLULAR TRANSFORMATION
Sanders, Stephanie (2016-04-26)Human T-cell Leukemia Virus Type 1 (HTLV-1) is a complex retrovirus which preferentially infects CD4+ T-cells. Endemic to Japan, regions of South America, Africa, and the Caribbean, HTLV-1 is transmitted through breastfeeding, ... -
JunD/HBZ enhances HBZ enhances HTLV-1 antisense transcription
Peloponese, Jean-Marie; Lemasson, Isabelle; Barbeau, Benoit; Mesnard, Jean-Michel (2011)Infection with the human T-cell leukemia virus type 1 (HTLV-1) results in a variety of diseases including adult T-cell leukemia (ATL), a fatal malignancy characterized by the uncontrolled proliferation of virally infected ... -
Molecular characterization of the activation domain of the HTLV-1 HBZ protein and its interaction with the KIX domain of the cellular transcriptional coactivators p300 and CBP
Cook, Pamela Renee (East Carolina University, 2010)The complex retrovirus human T-cell leukemia virus type I (HTLV-1) is the causative agent of adult T-cell leukemia (ATL). Deregulation of cellular transcription is thought to be a key event in virally-mediated T-cell ... -
NOVEL ROLE OF HUMAN T-CELL LEUKEMIA VIRUS TYPE-1 ENCODED PROTEIN HBZ IN VIRAL TRANSMISSION THROUGH CELL-TO-CELL CONTACT
Fazio-Kroll, Ana Laura (East Carolina University, 2017-04-28)The complex retrovirus Human T cell leukemia virus type I (HTLV-1) is the etiologic agent of several diseases, including Adult T cell leukemia (ATL), a fatal hematological malignancy that affects mainly CD4+ T-cells. Freshly ... -
Potential interference of HTLV-1 HBZ protein with the DNA damage response pathway
Wurm, Torsten; Lemasson, Isabelle (2011) -
Regulation of Human T-cell Leukemia Virus Type 1 Antisense Promoter by Myocyte Enhancer Factor-2C in the Context of Adult T-cell Leukemia and Lymphoma
Rushing, Amanda W.; Lemasson, Isabelle; et al (2022-05-26)