Browsing by Author "Lin, Chien-Te"
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Alternative splicing of UCP1 by non-cell-autonomous action of PEMT
Johnson, Jordan M.; Verkerke, Anthony R.P.; Maschek, J. Alan; Ferrara, Patrick J.; Lin, Chien-Te; Kew, Kimberly A.; Neufer, P. Darrell; Lodhi, Irfan J.; Cox, James E.; Funai, Katsuhiko (2019-11-08)Phosphatidylethanolamine methyltransferase (PEMT) generates phosphatidylcholine (PC), the most abundant phospholipid in the mitochondria and an important acyl chain donor for cardiolipin (CL) biosynthesis. Mice lacking ... -
Differential Dopamine D1 and D3 Receptor Modulation and Expression in the Spinal Cord of Two Mouse Models of Restless Legs Syndrome
Meneely, Samantha; Dinkins, Mai-Lynne; Kassai, Miki; Lyu, Shangru; Liu, Yuning; Lin, Chien-Te; Brewer, Kori L.; Li, Yuqing; Clemens, Stefan (2018-09-04)Restless Legs Syndrome (RLS) is often and successfully treated with dopamine receptor agonists that target the inhibitory D3 receptor subtype, however there is no clinical evidence of a D3 receptor dysfunction in RLS ... -
Diminished Force Production and Mitochondrial Respiratory Deficits are Strain-Dependent Myopathies of Subacute Limb Ischemia
McClung, Joseph; Schmidt, Cameron A.; Ryan, Terence E.; Lin, Chien-Te; Inigo, Melissa M. R; Green, Tom D.; Brault, Jeffrey J.; Spangenburg, Espen E. (2017-05-01) -
Diminished Force Production and Mitochondrial Respiratory Deficits are Strain-Dependent Myopathies of Subacute Limb Ischemia
Spangenburg, Espen; Schmidt, Cameron A.; Ryan, Terence E.; Lin, Chien-Te; Inigo, Melissa M.R.; Green, Tom D.; Brault, Jeffrey J.; McClung, Joseph M. (2017-05-01) -
Estrogen Receptor-α in Female Skeletal Muscle is Not Required for Regulation of Muscle Insulin Sensitivity and Mitochondrial Regulation
McClung, Joseph M.; Iñigo, Melissa R.; Amorese, Adam J.; Tarpey, Michael D.; Balestrieri, Nicholas P.; Jones, Keith G.; Patteson, Daniel J.; Torres, Maria.J.; Lin, Chien-Te; Smith, Cody D.; Heden, Timothy D.; McMillin, Shawna L.; Weyrauch, Luke A.; Stanley, Erin C.; Schmidt, Cameron A.; Funai, Katsuhiko; Gowdy, Kymberly M.; Witczak, Carol A.; Neufer, P. Darrell; Spangenburg, Espen E. (2020-04-01) -
Genetically Increasing Flux Through b-Oxidation in Skeletal Muscle Increases Mitochondrial Reductive Stress and Glucose Intolerance
Smith, Cody D.; Lin, Chien-Te; McMillin, Shawna L.; Weyrauch, Luke A.; Schmidt, Cameron A.; Smith, Cheryl A.; Witczak, Carol; Neufer, P. Darrell; Kurland, Irwin J. (2021) -
Heterozygous SOD2 Deletion Impairs Glucose-Stimulated Insulin Secretion, but Not Insulin Action, in High-Fat–Fed Mice
Kang, Li; Dai, Chunhua; Lustig, Mary E.; Bonner, Jeffrey S.; Mayes, Wesley H.; Mokshagundam, Shilpa; James, Freyja D.; Thompson, Courtney S.; Lin, Chien-Te; Perry, Christopher G.R.; Anderson, Ethan; Neufer, P. Darrell; Wasserman, David H.; Powers, Alvin C. (2014-11) -
The Influence of Energy Expenditure on Mitochondrial Functions, Oxidative Stress and Insulin Resistance under Metabolic Oversupply Conditions
Lin, Chien-Te (East Carolina University, 2011)Mitochondrial respiratory capacity and oxidative stress have been implicated in the development of insulin resistance (IR) and type II diabetes. A causative role of mitochondrial oxidative stress in the etiology of ... -
Mitochondrial Diagnostics: A Multiplexed Assay Platform for Comprehensive Assessment of Mitochondrial Energy Fluxes
Fisher-Wellman, Kelsey H.; Davidson, Michael T.; Narowski, Tara M.; Lin, Chien-Te; Koves, Timothy R.; Muoio, Deborah M. (2018-09-25)Chronic metabolic diseases have been linked to molecular signatures of mitochondrial dysfunction. Nonetheless, molecular remodeling of the transcriptome, proteome, and/or metabolome does not necessarily translate to ... -
Mitochondrial H₂O₂ emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
Anderson, Ethan; Lustig, Mary E.; Boyle, Kristen E.; Woodlief, Tracey L.; Kane, Daniel A.; Lin, Chien-Te; Price, Jesse W. III; Kang, Li; Rabinovitch, Peter S.; Szeto, Hazel H.; Houmard, Joseph A.; Cortright, Ronald N.; Wasserman, David H.; Neufer, P. Darrell (2009-03)High dietary fat intake leads to insulin resistance in skeletal muscle, and this represents a major risk factor for type 2 diabetes and cardiovascular disease. Mitochondrial dysfunction and oxidative stress have been ... -
Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity
Heden, Timothy D.; Johnson, Jordan M.; Ferrara, Patrick J.; Eshima, Hiroaki; Verkerke, Anthony R. P.; Wentzler, Edward J.; Siripoksup, Piyarat; Narowski, Tara M.; Coleman, Chanel B.; Lin, Chien-Te; Ryan, Terence E.; Reidy, Paul T.; Castro Brás, Lisandra E. de; Karner, Courtney M.; Burant, Charles F.; Maschek, J. Alan; Cox, James E.; Mashek, Douglas G.; Kardon, Gabrielle; Boudina, Sihem; Zeczycki, Tonya N.; Rutter, Jared; Shaikh, Saame Raza; Vance, Jean E.; Drummond, Micah J.; Neufer, P. Darrell; Funai, Katsuhiko (2019-09-11)Exercise capacity is a strong predictor of all-cause mortality. Skeletal muscle mitochondrial respiratory capacity, its biggest contributor, adapts robustly to changes in energy demands induced by contractile activity. ... -
Protein Kinase A Governs Oxidative Phosphorylation Kinetics and Oxidant Emitting Potential at Complex I
Lark, Daniel S.; Reese, Lauren R.; Ryan, Terence E.; Torres, Maria J.; Smith, Cody D.; Lin, Chien-Te (2015)he mitochondrial electron transport system (ETS) is responsible for setting and maintaining both the energy and redox charges throughout the cell. Reversible phosphorylation of mitochondrial proteins, particularly via ... -
Skeletal Muscle Undergoes Fiber Type Metabolic Switch Without Myosin Heavy Chain Switch in Response to Defective Fatty Acid Oxidation
Pereyra, Andrea S.; Lin, Chien-Te; Spangenburg, Espen E.; Neufer, P. Darrell; Fisher-Wellman, Kelsey; Ellis, Jessica M.; Sanchez, Daniela Mesa; Laskin, Julia (2022-02-09) -
TIGAR Deficiency Enhances Skeletal Muscle Thermogenesis by Increasing Neuromuscular Junction Cholinergic Signaling
Buddo, Katherine A.; Boykov, Ilya N.; Schmidt, Cameron A.; Lin, Chien-Te; Neufer, P. Darrell (2022-03-07)