Browsing Physiology by Author "Shibata, Yoshimi"
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Alveolar macrophage priming by intravenous administration of chitin particles, polymers of N-acetyl-D-glucosamine, in mice
Shibata, Yoshimi; Foster, L. Ann; Metzger, James; Myrvik, Quentin N. (East Carolina University, 1997-03)Intravenous (i.v.) administration of phagocytosable chitin particles (1 to 10 mm) in C57BL/6 mice and SCID mice primed alveolar macrophages (Mf) within 3 days to yield up to a 50-fold increase in their oxidative burst when ... -
Th1 Adjuvant N-Acetyl-d-Glucosamine Polymer Up-Regulates Th1 Immunity but Down-Regulates Th2 Immunity against a Mycobacterial Protein (MPB-59) in Interleukin-10-Knockout and Wild-Type Mice
Shibata, Yoshimi; Honda, Ikuro; Justice, J. Paul; Van Scott, Michael R.; Nakamura, Reiko M.; Myrvik, Quentin N. (East Carolina University, 2001-10)Treatment of mice with heat-killed (HK) Mycobacterium bovis BCG or 1- to 10-μm chitin particles (nonantigenic N-acetyl-d-glucosamine polymers) is known to induce innate immune responses, including gamma interferon (IFN-γ) ...