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Now showing items 21-28 of 28
Role of neuronal nitric oxide in the regulation of vasopressin expression and release in response to inhibition of cathecholamine synthesis and dehydration
(East Carolina University, 2007-10-22)
We used neuronal nitric oxide synthase (nNOS) gene knockout mice to study the effects of
catecholamines and neuronal nitric oxide on vasopressin expression in the hypothalamic
neurosecretory centers. nNOS gene deletion ...
The role of cardiac mitochondria in myocardial ischemia/reperfusion injury
(East Carolina University, 2012)
Cardiovascular disease (CVD) exerts economic and humanitarian costs that are unparalleled by any other disease. Of the many etiologies of CVD, myocardial infarction accounts for over 50% of the associated mortality and ...
The significance of mirna pathway in peripheral nerve regeneration following sciatic nerve injury.
(East Carolina University, 2012)
microRNAs (miRNAs) are small (21-23 nucleotides) single-stranded RNAs that play important roles in post-transcriptional regulation of gene expression. The binding of miRNA to its specific target mRNAs at 3' UTR causes ...
Influence of carbon nanomaterial exposure on pro-constrictor mechanisms during pregnancy
(East Carolina University, 2013)
Engineered carbon based nanoparticles (CNP) such as fullerenes and multiwalled carbon nanotubes (MWCNTs) are increasingly used in industries and in nanomedicine as a platform for drug delivery. Following environmental/o ...
Circadian influences on myocardial infarction
(2014-10-30)
Components of circadian rhythm maintenance, or “clock genes,” are endogenous entrainable oscillations of about 24 h that regulate biological processes and are found in the suprachaismatic nucleus (SCN) and many peripheral ...
LOCAL ADMINISTRATION OF CARBON MONOXIDE INHIBITS NEOINTIMA FORMATION IN BALLOON INJURED RAT CAROTID ARTERIES
(2005)
Recent studies indicate that systemic induction of heme oxygenase-1 (HO-1), which oxidatively degrades heme into iron, biliverdin, and carbon monoxide (CO), or adenoviral-mediated gene transfer of HO-1 inhibits neointima ...
Adenosine monophosphate-activated protein kinase inhibits vascular smooth muscle growth associated with vasculoproliferative disorders
(East Carolina University, 2013)
Vascular growth disorders are the major contributing factor to cardiovascular disease, the leading cause of morbidity and mortality worldwide. Aberrant vascular smooth muscle cell (VSMC) growth is a primary etiology ...
Tissue Salvage in the Non-reperfused Myocardium Mediated by (the absence of the circadian rhythm gene) mPer2 and (the receptor tyrosine kinase) EphrinA1
(East Carolina University, 2010)
Alterations in circadian rhythm have been associated with numerous cardiovascular pathologies. In project 1, we tested the hypothesis that functional mutation of the Per2 circadian clock gene would provide cardioprotection ...