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IMPACT OF INTRINSIC AEROBIC EXERCISE CAPACITY ON CARDIOVASCULAR OUTCOMES FOLLOWING VARIOUS FORMS OF CARDIOVASCULAR STRESS
(East Carolina University, 2020-06-22)
Cardiovascular diseases (CVD) remain the major leading cause of death in the western world. Therefore, several approaches to achieve cardioprotection against any cardiovascular insult have been explored and to date, the ...
Comparison of Mitochondrial Phenotypes Across Cancers with Different Tissues of Origin
(East Carolina University, 2021-12-06)
Cancer metabolism is typically characterized by aerobic glycolysis, an increase in glucose uptake and lactate production despite adequate sufficient oxygen availability to support mitochondrial oxidative phosphorylation ...
Deciphering the impact of fructose metabolism on liver mitochondrial bioenergetics
(East Carolina University, 2021-12-07)
Since its discovery in 1980, the interest in nonalcoholic fatty liver disease, the liver manifestation of metabolic syndrome, has expanded due to the growing impact on the world's health. Commonly characterized by ...
Utilizing Metabolomics and Proteomics for Clinical Applications
(East Carolina University, 2020-11-03)
Medical conditions such as heart failure and infant outcomes related to in utero drug exposure have become prevalent amongst the world population. As we observe alarming trends in poor health choices, treating these ...
Cardiovascular Outcomes Following Xenobiotic Pulmonary Exposures
(East Carolina University, 2017-07-06)
Cardiovascular disease remains the leading cause of mortality in the developed world. Over the past decades, investigations have demonstrated that pulmonary exposure to xenobiotic particulate matter promotes and exacerbates ...
Molecular Histology of EphrinA1 Expression in Mouse Heart Visualized Molecular Histology of EphrinA1 Expression in Mouse Heart Visualized with MALDI-MSI
(East Carolina University, 2018-07-25)
EphrinA1 is a tyrosine kinase receptor localized in the cellular membrane of healthy cardiomyocytes, the expression of which is lost upon myocardial infarction (MI). Intra-cardiac injection of the recombinant form of ...
Physiologic Determinants of Ischemic Skeletal Muscle Pathophysiology
(East Carolina University, 2018-11-29)
Lower limb peripheral arterial occlusive disease (PAD) has major impacts on patient quality of life and, in its most severe form, carries a significant risk of mortality. The canonical approach to PAD research has been ...
Enhanced Mitochondrial Superoxide Scavenging Does Not Improve Muscle Insulin Action in the High Fat-Fed Mouse
(2015-05)
Improving mitochondrial oxidant scavenging may be a viable strategy for the treatment of insulin resistance and diabetes. Mice overexpressing the mitochondrial matrix isoform of superoxide dismutase (sod2tg mice) and/or ...
Linking energy state to redox environment through mitochondrial redox circuits
(East Carolina University, 2016-11-16)
Mitochondria are the primary producers of intracellular H2O2, an oxidant signaling molecule that has gained attention for its role in normal physiological processes and disease etiologies such as skeletal muscle insulin ...