Browsing Dissertations and Theses by Title
Now showing items 1454-1473 of 2466
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Molecular mechanism of anandamide-induced apoptosis in non-melanoma skin cancer.
(East Carolina University, 2015)Non-melanoma skin cancer (NMSC) is the most common cancer in the United States. The absence of selective toxicity is the major problem associated with chemotherapeutic and radiation therapy for NMSCs. The goal of the present ... -
MOLECULAR MECHANISM OF ELLAGIC ACID AND UROLITHIN A IN THE SUPPRESSION OF PROSTATE CANCER BY INFLUENCING THE p53-MDM2 PATHWAY
(East Carolina University, 2019-07-10)Carcinoma of the prostate (CaP) is the most common cancer in men and the second leading cause of cancer-related death in men worldwide. Despite the available treatments for CaP including surgery and Androgen deprivation ... -
MOLECULAR MECHANISM OF THE CYTOTOXIC AND IMMUNOSTIMULATORY ACTIVITY OF 15 DEOXY PROSTAMIDE J2: INVESTIGATION OF CHOP10 AND NFĸB SIGNALING IN COLON CANCER
(East Carolina University, 2019-08-13)The endoplasmic reticulum (ER) stress pathway is a prominent regulator of cancer cell death and as a result, ER stress inducers are being exploited pharmacologically. Cytotoxic ER stress is typically regulated by the ... -
Molecular Mechanisms of Peripheral N-Methyl-D-Aspartate Mediated Pressor Response
(East Carolina University, 2012)The primary goal of this study was to characterize the N-Methyl-D-Aspartate (NMDA) receptor within the cardiovascular system and elucidate the molecular mechanisms involved in peripheral NMDA receptor-mediated pressor ... -
Molecular mechanisms of TMEFF2 action in Prostate Cancer
(East Carolina University, 2013)The transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2) is an evolutionarily conserved type I transmembrane protein expressed in the embryo and limited adult tissues, mainly the brain ... -
A Monte Carlo Evaluation of the Application of Variance Partitioning to the Assessment of Construct-related Validity
(East Carolina University, 2012)The present study presents a Monte Carlo evaluation of the application of variance partitioning to the assessment of the construct-related validity of assessment center (AC) post exercise dimension ratings (PEDRs). Data ... -
Morphology, Geologic History and Dynamics of Wimble Shoals, Rodanthe, NC
(East Carolina University, 2017-05-03)Barrier islands around the world protect estuaries and mainland areas, creating important habitat as well as environmentally and economically valuable property. Barrier islands represent 10%, of global shorelines and are ... -
A Mortuary Analysis of the Structure 7 Cemetery at Town Creek, a Mississippian Site in the Piedmont of North Carolina
(East Carolina University, 2013)Town Creek is a prehistoric Native American site in central North Carolina. The Mississippian period occupation, from about A.D. 1150-1350, saw the most intensive use of the site. The community transformed from a residential ... -
Moseley's Life in Ruins: The Excavation of Lot 34 and its Structural Remains at Brunswick Town
(East Carolina University, 2018-06-18)During excavations at Brunswick Town in 1959, an anomalous feature was uncovered and interpreted as a rammed earth foundation on politician Edward Moseley's property. However, it was never fully investigated. This style ... -
Mosquito Control in North Carolina : Funding Issues and Emergency Management
(East Carolina University, 2014)Natural disasters such as hurricanes may cause increases in mosquito abundance and, consequently, arbovirus transmission risk. In 2011, flooding from Hurricane Irene in eastern North Carolina (NC) resulted in increased ... -
The "Most Accurate, Least Factual" Writer : Hunter S. Thompson, Journalist
(East Carolina University, 2010)New Journalism, as practiced by Tom Wolfe, Jimmy Breslin, and other writers, loosened the accepted bounds of journalism in the 1960s. Embracing these unrestricted journalism practices, Hunter S. Thompson adapted the New ... -
Motility and chemotaxis in the Lyme disease spirochete Borrelia burgdorferi : role in pathogenesis
(East Carolina University, 2016-08-18)Lyme disease is the most prevalent vector-borne disease in United States and is caused by the spirochete Borrelia burgdorferi. The disease is transmitted from an infected Ixodes scapularis tick to a mammalian host. B. ... -
Motion-Based Segmentation of Medical MRI Images: A Review and Analysis
(East Carolina University, 2018-07-20)Image data produced in medical field assists doctors, surgeons and researchers to study muscle and tissue structure to identify and diagnose patient specific diseases and deficiency. Due to the complexity of muscle ... -
Motivation, achievement orientation, and competition in collegiate track and field athletes
(East Carolina University, 2014)Competition and motivation are important components of sports. Based on Self-Determination Theory and Cognitive Evaluation Theory (Deci &Ryan, 1985), this study had four purposes. The purposes of the current study were to: ... -
Motor Learning Guided Treatment with Childhood Apraxia of Speech: Cueing & Feedback
(East Carolina University, 2011)The aim of this study was to determine if participants with childhood apraxia of speech (CAS) respond with improved speech production when provided motor learning guided (MLG) treatment strategies. Five participants, ... -
Mouse Strain Dependent Differences in Muscle Fiber Type, Fiber Area, and Blood Perfusion in Response to Denervation Atrophy
(East Carolina University, 1/13/16)Skeletal muscle atrophy caused by denervation is a serious consequence of neuropathic disease, especially diabetes. However, the only proven treatment for muscle atrophy is exercise, which can be difficult or impossible ... -
Movements of North Carolina Striped Bass, Morone saxatilis, Inferred through Otolith Microchemistry
(East Carolina University, 2014)Striped Bass, Morone saxatilis, is an anadromous, recreationally and commercially important fish species found throughout the U.S. Atlantic east coast, whose migrations have been intensely studied. A review of the relevant ... -
Moving a Lighthouse : Cape Hatteras
(East Carolina University, 2010)Moving a Lighthouse is a collection of poems that focuses on the evolution of coastal fishing villages. This collection discusses the changing way of life on Hatteras Island. -
MOVING FROM THE MIDDLE: AN EXPLORATION OF STUDENT EXPERIENCES TRANSITIONING TO HIGH SCHOOL IN INTERNATIONAL SETTINGS
(East Carolina University, 2019-04-12)The current study sought to understand the stress of the eighth grade to high school transition at the International School Bangkok (ISB) and make recommendations for improving this experience. Transitioning from middle ... -
MRSL: AUTONOMOUS NEURAL NETWORK-BASED SELF-STABILIZING SYSTEM
(East Carolina University, 2015-12-15)Stabilizing and localizing the positioning systems autonomously in the areas without GPS accessibility is a difficult task. In this thesis we describe a methodology called Most Reliable Straight Line (MRSL) for stabilizing ...