Browsing Dissertations and Theses by Title
Now showing items 2393-2412 of 4831
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INVESTIGATING THE MOLECULAR MECHANISMS UNDERLYING SKIN FRAGILITY IN TP63-LINKED ECTODERMAL DYSPLASIAS
(East Carolina University, 2022-04-28)Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome and ectrodactyly-ectodermal dysplasia-cleft lip/palate (EEC) syndrome are two rare autosomal dominant disorders caused by heterozygous mutations occurring ... -
Investigating the Performance of the Visual Oddball Paradigm in the Context of Facial Recognition
(East Carolina University, 2021-06-03)The sequential visual oddball paradigm is a technique that is often used to elicit various components of cognitive event related potentials (ERPs). These components may serve as reliable biomarkers for neurodegenerative ... -
Investigating the Relationship Between Zetaproteobacteria and Cyanobacteria and its Implications for the Geological Record
(East Carolina University, 2022-07-14)Banded Iron Formations (BIFs) are geological relics of the ancient oceans that were partially formed by microorganisms. This includes oxygenic phototrophs and iron-oxidizing bacteria (FeOB) whose relative contributions are ... -
Investigating the Relationship Between Zetaproteobacteria and Cyanobacteria and its Implications for the Geological Record
(East Carolina University, 2022-07-14)Banded Iron Formations (BIFs) are geological relics of the ancient oceans that were partially formed by microorganisms. This includes oxygenic phototrophs and iron-oxidizing bacteria (FeOB) whose relative contributions are ... -
Investigating the Role of Conserved Cysteine Residues in Arabidopsis thaliana Diacylglycerol Acyltransferase 1
(East Carolina University, 2021-07-28)Triacylglycerols (TAGs) are biomolecules found in all organisms comprised of three fatty acid chains esterified to a glycerol backbone. In humans, TAGs are important energy storage reserves whose misregulation are associated ... -
Investigating the role of CRL5, an ubiquitin ligase, in ovarian follicle development.
(East Carolina University, 2016-07-20)During oogenesis, follicle cells surround maturing oocytes, which produce factors necessary for proper oocyte growth and development. Correct encapsulation of the oocyte by follicle cells is therefore essential for ... -
Investigating the Role of Poxvirus Virulence Genes A35 and O1L in the Virus Life Cycle
(East Carolina University, 2019-07-22)Poxviruses, some of the largest viruses in existence, have a great impact on the human and animal world due to their ability to infect a broad assortment of organisms and cause significant disease. Today, poxvirus infections ... -
Investigating the role of soil legacy effects and community engagement in the management of Lespedeza cuneata, an invasive legume
(East Carolina University, 2020-11-23)Invasive plant species present a growing threat to biodiversity. Many invasive plants are able to recruit microbial symbionts in their novel range and establish plant-soil feedbacks that influence growth and fitness. These ... -
Investigating the role of transcription factor, Trl, during germline development in the Drosophila ovary
(East Carolina University, 2019-07-22)Oogenesis is the process by which an egg develops from undifferentiated cells in the ovary. The Drosophila melanogaster ovary is an assembly line for egg production, making it a great system to investigate initial oocyte ... -
Investigating the Safety Challenges of Unmanned Aerial Vehicles (UAVs) in the Construction Environment
(East Carolina University, 2021-12-01)The technologies associated with Unmanned Aerial vehicles (UAVs) have revolutionized the construction industry, simultaneously demanding a comprehensive understanding of the underlying safety implications in order to reduce ... -
INVESTIGATING THE STAR SCHEMA BENCHMARK AS A REPLACEMENT FOR THE TPC-H DECISION SUPPORT SYSTEM
(East Carolina University, 2016-12-13)Decision Support System (DSS) are at the core of business intelligence systems. Implementation costs for enterprise level Database Management System (DBMS) and DSS average $10,461 for installation costs. This does not ... -
Investigating the Structural and Functional Roles of Conserved Cysteine Residues in Arabidopsis thaliana Fatty-Acid Desaturase 2
(East Carolina University, 2022-12-06)Plant-generated unsaturated fatty acids (UFAs) and polyunsaturated fatty acids (PUFAs) are vital to a plant's growth and survival through maintenance of plasma membrane fluidity and integrity, in addition to the various ... -
Investigation Into The Scope, Limitations, And Mechanistic Aspects Of A Regioselective Acylation Of Cycloplatinated Complexes
(East Carolina University, 2015)In the reaction of N-isopropyl-N-phenyl-2,2'-bipyridin-6-amine with potassium tetrachloroplatinate, the selective C-H bond activation was complicated by the low selectivity of sp² C-H bond activation in acetonitrile and ... -
An Investigation of Auditory and Visual Temporal Processing in Children with Reading Disorders
(East Carolina University, 2009)Several lines of research have revealed a relationship between reading disorders (RD) and auditory temporal processing deficits. That is, subtle, yet rapid changes within an acoustic message are more difficult for individuals ... -
Investigation of Curli-Specific Proteins CsgD and CsgA Reveals a Potential Target for Neurodegenerative Therapeutics and Provides Structural Insights into the Bacterial Amyloid CsgA
(East Carolina University, 2022-12-06)A growing body of evidence implicates curli-containing biofilms in the onset of neurodegenerative pathologies like Alzheimer's and Parkinson's diseases. Curli-containing biofilms are composed primarily of two bacterial ... -
Investigation of Molecular Mechanism of Transthyretin Oligomerization Associated with ATTR Amyloidosis
(East Carolina University, 2022-04-27)Transthyretin amyloidosis (ATTR) has classically been diagnosed predominantly post-observation of amyloid fibril deposition on soft tissues within the body, however, recent studies have shown that oligomers which arise ... -
Investigation of NADPH-Dependent Thioredoxin Reductase-C (NTRC) In Chloroplast Lipid Metabolism
(East Carolina University, 2022-07-01)Redox reactions are ubiquitous within plant metabolism and critical for the sustainment of photosynthesis within thylakoid membranes. Specialized glycerolipids that make up these membranes in turn require redox reactions ... -
Investigation of NADPH-Dependent Thioredoxin Reductase-C (NTRC) In Chloroplast Lipid Metabolism
(East Carolina University, 2022-07-01)Redox reactions are ubiquitous within plant metabolism and critical for the sustainment of photosynthesis within thylakoid membranes. Specialized glycerolipids that make up these membranes in turn require redox reactions ...