Browsing Dissertations and Theses by Title
Now showing items 3642-3661 of 4831
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The significance of mirna pathway in peripheral nerve regeneration following sciatic nerve injury.
(East Carolina University, 2012)microRNAs (miRNAs) are small (21-23 nucleotides) single-stranded RNAs that play important roles in post-transcriptional regulation of gene expression. The binding of miRNA to its specific target mRNAs at 3' UTR causes ... -
Simulating and Optimizing a Zero-Waste Wave-To-Water Desalination System
(East Carolina University, 2023-04-28)Current methods of producing clean water are not capable of meeting growing demands. One method of producing clean water is through a process called desalination, which is the process of removing salt and other minerals ... -
A single dose of metformin improves whole body insulin sensitivity and alters cellular redox state in skeletal muscle of Zucker fa/fa rats
(East Carolina University, 2010)Energy balance is considered a fundamental requirement of life forms from single cell organisms to higher mammals such as humans. Unfortunately, our species has also discovered the detrimental metabolic responses to excess ... -
A SINGLE-CHAIN GMCSF-MOG TOLEROGENIC VACCINE EXPANDS MOG-SPECIFIC CD25+ FOXP3+ REGULATORY T CELLS THROUGH LOW-EFFICIENCY ANTIGEN RECOGNITION EVENTS TO INHIBIT EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
(2019-12)Previous studies showed that tolerogenic vaccines comprised of single-chain GMCSF-neuroantigen (NAg) fusion proteins inhibited experimental autoimmune encephalomyelitis (EAE) in rodents. The studies detailed here provide ... -
Sister Sledge Said It Best— “We are Family”: Chosen Family in LGBTQ+ Young Adult Literature
(East Carolina University, 2022-07-19)This thesis will explore the concept of chosen, or voluntary, family as it relates to fictional depictions of young adults who identify as part of the LGBTQ+ community. The introductory chapter of this thesis will discuss ... -
Sister Sledge Said It Best— “We are Family”: Chosen Family in LGBTQ+ Young Adult Literature
(East Carolina University, 2022-07-19)This thesis will explore the concept of chosen, or voluntary, family as it relates to fictional depictions of young adults who identify as part of the LGBTQ+ community. The introductory chapter of this thesis will discuss ... -
SITE FORMATION AND CORROSION PROCESSES: A Comparative Analysis of Condor and Stormy Petrel Wreck Sites
(East Carolina University, 2019-04-17)Submerged cultural resources abound in North Carolina waters, and two Civil War blockade runners built, launched, and sunk within months of each other provide an opportunity to review site formation processes through a ... -
Skeletal Muscle Eukaryotic Elongation Factor 2 (eEF2) Response to Acute Resistance Exercise in Young and Old Men and Women : Relationship to Muscle Glycogen Content and 5'-AMP-Activated Protein Kinase (AMPK) Activity
(East Carolina University, 2010)Sarcopenia is associated with an age-related decrease in skeletal muscle mass, which can result in decreases in strength and physical functioning in the older population. Resistance training interventions are not completely ... -
Skeletal Muscle Forkhead Box 3A (FOXO3A) Response to Acute Resistance Exercise in Young and Old Men and Women : Relationship to Muscle Glycogen Content and 5'-AMP Activated Protein Kinase (AMPK) Activity
(East Carolina University, 2010)In addition to suppressing protein synthesis, 5'-AMP-activated protein kinase (AMPK) stimulates muscle protein degradation through forkhead box transcription factor 3A (FOXO3A), known to promote transcription of mRNAs ... -
SKELETAL MUSCLE INSULIN SENSITIVITY AND DURATION OF TYPE 2 DIABETES MELLITUS
(East Carolina University, 2012)Type 2 Diabetes Mellitus (T2DM) resolution following Roux-en Y gastric bypass (RYGB) surgery is reduced in patients with longer duration of T2DM and preliminary data suggest this may be mechanistically linked to lower ... -
SKELETAL MUSCLE LIPID PARTITIONING : CONSEQUENCES OF ALTERATIONS IN ACYL-COA SYNTHETASE-5 AND DIGLYCERIDE ACYLTRANFERASE-1 EXPRESSION
(East Carolina University, 2011)An oversupply of fatty acids and inadequacies in their partitioning toward oxidation and/or storage will lead to disruptions in cellular homeostasis. Reductions in mitochondrial content and lower rates of fatty acid ... -
SKELETAL MUSCLE METABOLIC FLEXIBILITY IMPAIRMENTS IN RESPONSE TO LIPID WITH OBESITY : EFFECT OF EXERCISE TRAINING
(East Carolina University, 2012)Obese individuals exhibit skeletal muscle metabolic inflexibility by failing to increase fat oxidation and genes linked with mitochondrial biogenesis in response to a high-fat diet (HFD) and lipid incubation in cell culture. ... -
Skeletal Muscle Purine Nucleotide Degradation and Atrophy: Cause or Consequence of Increased Uric Acid Production
(East Carolina University, 2022-07-26)Elevated serum uric acid is a risk factor for mortality in diseases and critical illnesses associated with skeletal muscle atrophy. Uric acid is generated by xanthine oxidoreductase (XOR) and XOR inhibitors can partially ... -
Skeletal Muscle Purine Nucleotide Degradation and Atrophy: Cause or Consequence of Increased Uric Acid Production
(East Carolina University, 2022-07-26)Elevated serum uric acid is a risk factor for mortality in diseases and critical illnesses associated with skeletal muscle atrophy. Uric acid is generated by xanthine oxidoreductase (XOR) and XOR inhibitors can partially ... -
Skin Carotenoid Levels Over Time and Differences by Age, Sex, and Race Among Head Start Children (3-5 years) Living in Eastern North Carolina
(East Carolina University, 8/5/2020)Objective: Examine differences in skin carotenoid levels (SCL) based on time, age, sex, and race of preschool-aged children (PSAC) enrolled in Head Start (HS) in North Carolina (NC). Design: Data were collected using surveys ...