Browsing Dissertations and Theses by Title
Now showing items 4464-4483 of 4831
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Thermodynamic and Spectroscopic Investigations of Novel Antimicrobial Peptides containing Unnatural Amino Acids with Model Membrane Systems
(East Carolina University, 2011)With the over prescription and use of antibiotic drugs the evolution of drug resistant bacteria strains has become a world wide health crisis. In response to this crisis, the search for new drugs to kill bacteria via a ... -
Thermodynamic and spectroscopic studies of Cd²⁺ binding to the regulatory domain and full length human cardiac troponin C (HcTnC) : elucidating plausible Cd²⁺ binding sites
(East Carolina University, 2015)Toxic metals such as cadmium (Cd²⁺) have been shown to bind to and interfere with various calcium (Ca²⁺) binding proteins including the regulatory protein cardiac troponin C (cTnC). Recent structural data has shown that ... -
Thermodynamic and Structural Characterization of Cd(II) binding to human cardiac troponin C: Using Mutants and Truncated Constructs to Elucidate Cd(II) binding sites
(East Carolina University, 8/5/2020)Many biological processes rely on the presence of essential metals; therefore, maintaining the concentration of metals is paramount to homeostasis. Cadmium, Cd(II), is a toxic heavy metal that can disturb this delicate ... -
Thermodynamic Investigation into the Binding Properties of Cardiac Troponin (Human and Bovine)
(East Carolina University, 2010)Troponin is an integral protein in the mechanism of muscle contraction. In order to induce cardiac muscle contraction, Ca[superscript]2[superscript]+ must bind to the TnC subunit (calcium binding subunit) of troponin to ... -
Thermodynamic Investigation of Copper Binding to the Amyloid-Beta (A[beta]) Peptide
(East Carolina University, 2010)Alzheimer's disease is a fatal and neurodegenerative disease with as many as 5.3 million Americans living with the disease. One of the characteristic hallmarks of Alzheimer's is the amyloid plaques that build up around the ... -
Thermodynamic Investigations into Copper Binding in the N-Terminal Region of the Prion Protein at Low Copper Loadings
(East Carolina University, 2010)The prion protein (PrP) is a naturally occurring protein found at high levels in central nervous system (CNS). The misfolding of the PrP is responsible for neurodegenerative diseases called transmissible spongioform ... -
Thermodynamic studies of Ca²⁺ binding to human cardiac troponin C
(East Carolina University, 2012)Human Cardiac Troponin C (HcTnC) is an EF hand protein responsible for initiating contraction of the myocardium (heart muscle). The helix-loop-helix motif, characteristic of members of the EF-hand family, allows HcTnC to ... -
Thesis - generating knowledgebase of common behavior and workflow patterns for secure systems
(East Carolina University, 2018-05-02)Knowledge discovery from large data for system security management and threat detection have been a complex task due to large number of users and the dynamic nature of distributed systems. Healthcare organizations as a ... -
"They Would Have a Law of Their Own" : The Discourse on Smuggling at the Old Bailey, 1736-1814
(East Carolina University, 2013)This thesis examines the cases of 136 men tried for smuggling offenses at London's central criminal court during the long eighteenth century. Before the 1770s, the government portrayed smuggling as a crime against the ... -
They're Speaking Gender Identity, Agency, and Belonging in an International Middle School
(East Carolina University, 2023-04-17)The purpose of the study was to better understand how international school middle school teachers can help cultivate a student's sense of belonging by creating a space for students to explore factors shaping their gender ... -
The Things We Hear in the Nighttime & Other Stories
(East Carolina University, 2015)THE THINGS WE HEAR IN THE NIGHTTIME & OTHER STORIES is a collection of five short stories and five pieces of flash fiction. The writing in the collection focuses on the ever-changing American identity of the 20th and 21st ... -
Thoughts on Temporal Perception's Relativity in Grisey's Vortex Temporum and Voss's Perspectives
(East Carolina University, 2017-07-21)This thesis centers around a comparative analysis between an instrumental work, Vortex Temporum (1995), by Gérard Grisey (1946-98), and a mixed media work by Emerson Voss (b. 1991), Perspectives (2017). This essay articulates ... -
THREAT ASSESSMENT AND MANAGEMENT: PROTOCOL AND BUDGETARY NEEDS FOR TOOLS AND MEMBER TRAINING IN HIGHER EDUCATION
(East Carolina University, 2021-04-20)The primary goal of threat assessment is to prevent individuals who are on a pathway to violence. Threat assessment entails a three-step process beginning with identifying a concern, assessing the risk and managing the ... -
Threat Modelling and Analysis of Web Application Attacks
(East Carolina University, 2018-12-12)There has been a rapid growth in the use of the Internet over the years with billions of businesses using it as a means of communication. The World Wide Web has served as the major tool for disseminating information which ... -
THREE FACETS OF EMPLOYEE WELLNESS: THE POTENTIAL MODERATING INFLUENCES OF MINDFULNESS, PHYSICAL ACTIVITY, AND VACATION ON SELECT WORKER CHARACTERISTICS
(East Carolina University, 2020-06-22)Workaholism is well-known for the negative effects it has on workers, including poor individual health and an inability to separate oneself from work. Furthermore, a strong positive correlation between workaholism and work ... -
Three Generations, One Future: A Systematic Analysis on Nicotine's Effect across generations in C. elegans.
(East Carolina University, 2013)Tobacco smoking is a worldwide epidemic that is responsible for diseases and death rates that surpass those attributed to a combination of other causes (e.g. cancer, HIV, accidents). A major mediator of tobacco-smoke related ...