Browsing Dissertations and Theses by Title
Now showing items 1069-1088 of 4831
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Deciphering the impact of fructose metabolism on liver mitochondrial bioenergetics
(East Carolina University, 2021-12-07)Since its discovery in 1980, the interest in nonalcoholic fatty liver disease, the liver manifestation of metabolic syndrome, has expanded due to the growing impact on the world's health. Commonly characterized by ... -
Deciphering the Role of Long-chain Acyl-CoA Synthetase 6 in Brain Lipid Metabolism and Neuroprotection
(East Carolina University, 2021-04-27)The omega-3 fatty acid, docosahexaenoic acid (DHA), is highly enriched in the central nervous system (CNS) and thought to protect against neurological dysfunction. Due to its neuroprotective nature, DHA is widely considered ... -
Decisional Balance Among Potential ICD Recipients : Development Of The Implantable Cardioverter Defibrillator Decision Analysis Scale (ICD-DAS)
(East Carolina University, 2011)Sudden cardiac death is a well-documented public health problem resulting in 400,000 deaths in the U.S. annually. The Implantable Cardioverter Defibrillator (ICD) has demonstrated benefit in reducing mortality in at risk ... -
Decisions Under Duress: Influences on Official Decision Making During Superstorm Sandy
(East Carolina University, 2015-12-08)During impending storms, emergency managers and politicians are tasked with the difficult decision of whether or not to issue evacuation orders for their area. This study uses Superstorm Sandy as a case study and investigates ... -
The Declaration of Independence : A New Genre in Political Discourse or Mixed Genres in an Unlikely Medium?
(East Carolina University, 2011)The dissertation shows how mismatched content/medium relationships can supersede the responses of traditional pairings when the medium dominates the discursive power of the discourse. The dissertation, in part, looks at a ... -
Decolonizing Education : A Critical Discourse Analysis of Post-Secondary Humanities Textbooks
(East Carolina University, 2012)This dissertation examines nine post-secondary humanities textbooks published between 2001 and 2011 using an approach that includes both qualitative and quantitative methodology to analyze the written and visual content ... -
Defend Your Coast: Network Analysis of Crusader Fortifications and Settlements Within the Kyrenia Region of Cyprus
(East Carolina University, 2019-04-26)The Mediterranean island of Cyprus is situated at the crossroads of the Near East and the Aegean Civilizations. During the Middle Ages, Cyprus experienced raids that would devastate the coastal landscape. Coastal towns and ... -
Defending the East Coast : Adapting and Converting Commercial Ships for Military Operations
(East Carolina University, 2015)The United States was not fully prepared for war in the Atlantic Ocean directly after the bombing of Pearl Harbor on 7 December 1941. Closely following the attack, Germany declared war on the United States and Hitler's ... -
Defining B-29 Airscapes in the Archaeological Record as a Predictive Model for Site Location
(East Carolina University, 2018-04-27)The Boeing B-29 Superfortress made history when it dropped atomic bombs on Hiroshima and Nagasaki, Japan, bringing an end to World War II. Based on a small island in the central Pacific Ocean, this colossal aircraft left ... -
Defining Eastern North Carolina Upriver Steamboats Through Tar River Archaeology and History
(East Carolina University, 2012)This thesis will identify the salient features of North Carolina upriver steamboats and their relationships to steamboats from a variety of regions in the United States in an effort to understand the means by which people ... -
Defining God, Love, and Grammar
(East Carolina University, 2014)Based on textual research and general discussion in academia, a field-accepted definition of grammar for the purposes of first-year writing does not yet exist. In order to provide a working definition of grammar, forty-six ... -
Defining Protein Motions the Comprise the Reaction Barrier in Human Epithelial 15-Lipoxygenase-2
(East Carolina University, 2022-04-27)Proteins are dynamic in nature, with these motions playing a role in substrate binding and product release. Protein thermal motions have emerged as participating in the bond making/breaking steps of catalysis and by extension ... -
DEFINING THE ABILITY OF SNAT NANOTHERAPEUTIC TO INHIBIT SARS-COV-2 INFECTION AND ALTER THE HOST MICRONOME TO INDUCE AN ANTIVIRAL CELLULAR ENVIRONMENT
(East Carolina University, 2023-12-07)MicroRNAs (miRNAs) are regulatory elements that canonically bind to target mRNAs, reducing translation and protein output. They are non-coding strands of RNA, roughly 18-25 nucleotides long, and are found in plants, animals, ... -
Defining the Great Lakes Passenger Freight Propeller: A Statistical, and Historical Study
(East Carolina University, 2018-12-06)Passenger freight propellers were integral to the Great Lakes economy for nearly 100 years. A unique vessel type created for a unique need, shipbuilders combined different new technologies to create faster, more efficient, ... -
Defining the role of acyl-CoA synthetase 6 on α-synucleinopathy
(East Carolina University, 2022-07-19)Background: Neurodegenerative diseases known as [alpha]-synucleinopathies, most notably dementias and Parkinson's Disease (PD), are characterized by neuronal aggregation and accumulation of [alpha]-synuclein ([alpha]-syn) ... -
Defining the role of acyl-CoA synthetase 6 on α-synucleinopathy
(East Carolina University, 2022-07-19)Background: Neurodegenerative diseases known as α-synucleinopathies, most notably dementias and Parkinson’s Disease (PD), are characterized by neuronal aggregation and accumulation of α-synuclein (α-syn) in a manner that ... -
Defining the Role of the C-Terminal Region of Troponin T by Analysis of a Series of Truncation Mutants
(East Carolina University, 2016-07-21)Familial hypertrophic cardiomyopathy and other cardiovascular diseases result from mutations of any of the contractile proteins. Mutations within the actin binding regulatory complex of proteins, including tropomyosin (Tm) ... -
DEFINING THE STRATIGRAPHIC AND PALEOENVIRONMENTAL RECORD OF RAPID SEA-LEVEL RISE DURING THE LATE PLEISTOCENE TO HOLOCENE IN THE ALBEMARLE SOUND REGION OF NORTH CAROLINA
(East Carolina University, 2022-08-19)Sea-level fluctuations throughout the late Quaternary Period are recorded in the shallow stratigraphy and modern geomorphology of coastal North Carolina. In the Albemarle Sound region, four distinct Pleistocene sea-level ... -
DEFINING THE STRATIGRAPHIC AND PALEOENVIRONMENTAL RECORD OF RAPID SEA-LEVEL RISE DURING THE LATE PLEISTOCENE TO HOLOCENE IN THE ALBEMARLE SOUND REGION OF NORTH CAROLINA
(East Carolina University, 2022-08-19)We need to replace the abstract.