Browsing Dissertations and Theses by Subject "Cadmium"
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The Thermodynamics of Cd(II) Binding to Human Cardiac Troponin C: Using Mutants to Determine the Location of Cd(II) Binding
(East Carolina University, 2017-05-31)Historically, cadmium (Cd) has been used in many different applications from cadmium paint to nickel-cadmium batteries. However, Cd is a nonessential, naturally occurring toxic element due to its low excretion rate and ... -
Thermodynamic and Structural Characterization of Cd(II) binding to human cardiac troponin C: Using Mutants and Truncated Constructs to Elucidate Cd(II) binding sites
(East Carolina University, 8/5/2020)Many biological processes rely on the presence of essential metals; therefore, maintaining the concentration of metals is paramount to homeostasis. Cadmium, Cd(II), is a toxic heavy metal that can disturb this delicate ... -
Toxic Metal Interactions with Human Cardiac Troponin C and Cysteine Replacement Mutants: Investigating Potential Cd(II) Binding to Cysteine Thiols Using DTNB Time Course Assays
(East Carolina University, 2021-07-26)Calcium binding proteins contribute to all aspects of cell function by binding to calcium directly. Human Cardiac Troponin C (hcTnC) belongs to the EF-hand family of calcium binding proteins. This specific protein is ...