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Developmental lead exposure and the exacerbation of Alzheimer's pathology: an immunological analysis
(East Carolina University, 2014)
Early neuroimmune dysfunction may play a driving role in the etiopathology of Alzheimer's disease (AD), stemming from the hypothesis that many late-stage adult diseases have an early-life basis. Here we explore whether ...
Interrelated role of Notch signaling and mTORC pathways in prostate cancer cell survival and growth
(East Carolina University, 2014)
Prostate cancer is currently the second highest leading cause of
cancer death in men. Notch is a transmembrane receptor protein that
is part of a signaling pathway necessary in the normal development of
the prostate. ...
Gesture Prediction Model for the Guitar Fingering Problem
(East Carolina University, 2014)
In this thesis we provide a method for finding the fingering of a music piece on any type of guitar using a hand model. Adapting to the real world conditions by deploying a model of the user's hand, and considering the ...
Blue Guardian Original TV Series : Two Episodes, Blue Tornado and Blue Mountains
(East Carolina University, 2014)
Blue Guardian is an original TV series with two episodes presented here, entitled "Blue Tornado" and "Blue Mountains." It is in the mystery genre without particularly dealing with murder investigations. Rather, each ...
The Infamous Convict Museum Ship Success : an Archaeological Investigation of Material Culture and Identity Formation Processes
(East Carolina University, 2014)
This thesis examines the relationship between material culture and the formation of cultural identity through an analysis of the artifact assemblage from the former traveling museum ship, Success. Before sinking near Port ...
MAJOR AND TRACE ELEMENT CHEMICAL COMPOSITION OF GAHNITE FROM GRANITIC PEGMATITES AND A METAMORPHOSED MASSIVE SULFIDE DEPOSIT : SIGNIFICANCE FOR PEGMATITE FRACTIONATION AND DISCRIMINATION BETWEEN Li-RICH AND Li-POOR PEGMATITES
(East Carolina University, 2014)
Rare-element granitic pegmatites are common hosts to economic deposits of rare metals, including Li, Ta, and rare-earth elements, which are increasing in economic importance due to advancing technology. Gahnite (ZnAl₂O₄) ...
A Determination Worthy of a Better Cause : Naval Action at the Battle of Roanoke Island 7 February 1862
(East Carolina University, 2014)
The Battle of Roanoke Island, during the American Civil War, was one of the first major amphibious landing operations in U.S. military history. As the Union Army landed troops on the island, an accompanying Union Naval ...
Elizabeth I, Visual Icon : A Title Unintended
(East Carolina University, 2014)
This thesis explores Elizabeth I's relationship with her official state portraiture to show that she placed little value in its meaning and authority for political and diplomatic uses. Understanding her personal relationship ...
Maternal input of Striped Bass (Morone saxatilis) : Determining a mother's life history from its progeny in coastal North Carolina
(East Carolina University, 2014)
Otolith studies have become more prevalent in recent years as use has expanded from ageing to examination of migration patterns and fidelity to natal habitats, and more recently examining otoliths for possible maternal ...
Electrochemical Detection of Benzo[a]Pyrene-Induced DNA Damage at TP53 Oligomers : Impact of 5'-Methyl Cytosine and Bioactivation on the Genotoxicity Process
(East Carolina University, 2014)
DNA houses the blueprint that dictates how an organism will develop. However, DNA features numerous reactive sites that can be attacked by chemicals and radiation, resulting in DNA damage and possibly mutations. Chemical ...