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CRISPR/Cas9 knockout of HAS2 in rat chondrosarcoma chondrocytes demonstrates the requirement of hyaluronan for aggrecan retention
(East Carolina University, 2016-12-15)
Hyaluronan (HA) plays an essential role in cartilage where it functions to retain aggrecan. Previous studies suggested that aggrecan is anchored indirectly to the plasma membrane of chondrocytes via its binding to ...
Toxic Effects of Chlorpyrifos Exposure on Development of Caenorhabditits Elegans
(East Carolina University, 2016-12-15)
Chlorpyrifos is a commonly utilized organophosphate pesticide, and as recently as 2007, was the most commonly used insecticide within the United States. Its ubiquity is concerning given its potential to cause developmental ...
Investigation of possible driving forces on counter-intuitive thermal collapse of intrinsically disordered proteins
(East Carolina University, 2016-08-18)
Intrinsically disordered proteins are an emerging class of proteins that contain no secondary or tertiary structure. Through bioinformatics studies it has been predicted that a third of the human proteome consists of ...
Effect of previous hamstring strain on Anterior Cruciate Ligament (ACL) forces
(East Carolina University, 2016-08-18)
Introduction: Anterior Cruciate Ligament (ACL) injuries are very common in the athletic population. While the hamstring muscles help protect the ACL, hamstring strain injuries (HSI) are also common in sports. After HSI, ...
Developmental pathway alterations in the stress axis of chickens exposed in ovo to an emerging environmental contaminant
(East Carolina University, 2016-12-13)
Pharmaceutical and personal care products are present in the natural environment by way of the wastewater stream. They are persistent in the environment and have bioaccumulative abilities that threaten the health of both ...
AN INVESTIGATIVE STUDY OF THE NEUROPSYCHOLOGICAL AND NEUROPHYSIOLOGICAL FEATURES OF SUBJECTIVE SLEEP QUALITY
(East Carolina University, 2016-12-06)
Background: Disordered sleep is a national health issue affecting an estimated 50-70 million US adults. The documented consequences of disordered sleep include impaired daily function, increased risk for chronic health ...
Predicting length of treatment involvement of substance using perinatal women in an integrated inpatient healthcare program
(East Carolina University, 2016-12-16)
Services for perinatal (pregnant and one year postpartum) women are limited, and inpatient settings where women receive substance abuse services specific to the perinatal population, although ideal, are rare in eastern ...
PERCEIVED EFFECTIVENESS OF A DRIVING AND COMMUNITY MOBILITY BOOTCAMP FOR INDIVIDUALS WITH AUTISM SPECTRUM DISORDER
(East Carolina University, 2016-12-15)
This study was designed to determine the perceived effectiveness of a driving and community mobility Bootcamp for young adults with high functioning autism spectrum disorder (HFASD). Seven participants and their parents ...
Relation of adaptive and maladaptive perfectionism to behavioral activation, behavioral inhibition, and heart rate variability
(East Carolina University, 2016-08-18)
Background: Recent research has indicated that different subtypes of perfectionism are differentially related to stress, coping, and psychophysiology, with individuals who exhibit higher levels of maladaptive perfectionism ...
The Predicament of Traditional Femininity: A Gender Material Culture Analysis of Civil War Blockade Runners
(East Carolina University, 2016-11-16)
This thesis will seek to examine the tension between nineteenth-century Southern gender expectations of upper-class femininity contrasted with the necessities of wartime and determine if this tension is evident in the ...