Search
Now showing items 231-240 of 254
Development of small-molecule inhibitors of the initiating proteases, C1r and C1s, of the classical complement pathway
(East Carolina University, 2019-12-12)
Complement is a proteolytic cascade that upon activation plays a key effector role in the innate immune system and acts to prime the adaptive immune response. During normal homeostatic events, complement is tightly regulated ...
ANXIETY AND FEAR IN RELATION TO SLEEP AND NEUROPHYSIOLOGY IN A SAMPLE OF COLLEGE STUDENTS
(East Carolina University, 2019-12-12)
Long-term poor sleep contributes to the development and maintenance of chronic disease and physical and mental health challenges. Researchers have sought to understand the myriad of factors that influence sleep behavior, ...
Exploring Latino Parent and School Staff Perspectives on Latino Parent Involvement in Public Schools
(East Carolina University, 2019-12-10)
The purpose of this qualitative study was to explore experiences and culturally appropriate practices of Latino parents' participation in the public school system. The study also explored school staff perceptions and actions ...
WHAT LIES BENEATH AT THE PINE STREET BARGE CANAL BREAKWATER SHIP GRAVEYARD: SITE FORMATION PROCESSES AS A DOCUMENT OF CHANGE IN BURLINGTON, VERMONT (C. 1830-1960)
(East Carolina University, 2019-11-14)
The Pine Street Barge Canal Breakwater Ship Graveyard in the waterfront of Burlington, Vermont contains a small assemblage of abandoned vessels along the shores of Lake Champlain. Representing a span of time dating from ...
Determining the role of the steroid hormone ecdysone in critical stages of Drosophila melanogaster early oogenesis
(East Carolina University, 2019-11-27)
Reproductive function in many organisms, including Drosophila melanogaster, is controlled by steroid hormones. The main steroid hormone in Drosophila is ecdysone, which is structurally and functionally similar to estrogen. ...
GROUNDWATER FLOW IN THE UPPER CASTLE HAYNE AQUIFER: NUMERICAL SIMULATIONS AND STRONTIUM ISOTOPIC INVESTIGATIONS
(East Carolina University, 2019-10-02)
The Castle Hayne Aquifer System (CHAS) is the most extensively used aquifer system in the North Carolina Coastal Plain. Heavy groundwater withdrawals from the Upper Castle Hayne Aquifer (UCH) have occurred since the 1960’s ...
Theoretical Probe to the Mechanism of Pt-catalyzed C-H Acylation Reaction: Possible Pathways for the Key Acylation Reaction of Platinacycles
(East Carolina University, 2019-08-23)
Transition metal-catalyzed C-H bond functionalization offers a variety of desirable transformations of simple hydrocarbons to more complex compounds with applications being applied in pharmaceuticals to material sciences. ...
“LIVING OFF THE GRID”: THE INFLUENCE OF COMPANION CANINES ON ONE’S QUALITY OF LIFE
(East Carolina University, 2019-08-23)
Estimates of individuals experiencing homelessness in the United States range between 549,928-643,067 on any given day (National Coalition for the Homeless, 2018; Green Doors, n.d.). Among those individuals experiencing ...
The Transformation of the South as Presented in the Literature of Southern African American Women: Harriet Jacobs, Octavia Rogers, and Zora Neale Hurston
(East Carolina University, 2019-08-23)
Incidents in the Life of a Slave Girl (1861) by Harriet Jacobs, The House of Bondage (1890) by
Octavia Rogers Albert, and Their Eyes Were Watching God (1937) by Zora Neale Hurston
provide accounts of historical time ...
Matrix Metalloproteinase 12 is Critical for Granuloma Formation in the Murine Model of Granulomatous disease
(East Carolina University, 2019-08-16)
Matrix Metalloproteinase 12 (MMP12) is a protein produced primarily by alveolar macrophages that degrades elastin in the extracellular matrix (ECM) and enables infiltration of immune cells that participate in the inflammatory ...