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Now showing items 171-180 of 254
Developmental lead exposure and the exacerbation of Alzheimer's pathology: an immunological analysis
(East Carolina University, 2014)
Early neuroimmune dysfunction may play a driving role in the etiopathology of Alzheimer's disease (AD), stemming from the hypothesis that many late-stage adult diseases have an early-life basis. Here we explore whether ...
Interrelated role of Notch signaling and mTORC pathways in prostate cancer cell survival and growth
(East Carolina University, 2014)
Prostate cancer is currently the second highest leading cause of
cancer death in men. Notch is a transmembrane receptor protein that
is part of a signaling pathway necessary in the normal development of
the prostate. ...
Fundamental and Applied Studies on Chromatographic Separation of Cold Drugs and Skincare Creams and Extraction of Salvia miltiorrhiza using Subcritical Water
(East Carolina University, 2014)
Subcritical water chromatography (SBWC) and subcritical water extraction (SBWE) are two green techniques that use subcritical water as the sole solvent for separations, thus eliminating the use of toxic and expensive organic ...
Comparison of ZnO nanoparticles and ZnCl₂ induced germ cell apoptosis in Caenorhabditis elegans
(East Carolina University, 2014)
There is inadequate research data available on manufactured ZnO nanoparticles. Manufactured nanoparticles are widely used in various products and production of manufactured nanoparticles is becoming increasingly abundant. ...
Elizabeth I, Visual Icon : A Title Unintended
(East Carolina University, 2014)
This thesis explores Elizabeth I's relationship with her official state portraiture to show that she placed little value in its meaning and authority for political and diplomatic uses. Understanding her personal relationship ...
Maternal input of Striped Bass (Morone saxatilis) : Determining a mother's life history from its progeny in coastal North Carolina
(East Carolina University, 2014)
Otolith studies have become more prevalent in recent years as use has expanded from ageing to examination of migration patterns and fidelity to natal habitats, and more recently examining otoliths for possible maternal ...
The Effects of Moral Self-Reflective Priming on Faking in Personality Testing
(East Carolina University, 2014)
Personality testing has received considerable criticism due to validity coefficients being weakened by intentional response distortion. The current study investigates whether priming an individual with a moral self-reflective ...
"Of my own accord" : Milton's Dialogue with the Rabbis in Samson Agonistes
(East Carolina University, 2014)
This thesis examines rabbinic commentaries on the Samson story and the ways in which Milton appropriates or differs from these interpretations. It considers the critical debate over whether Samson's character and violent ...
Electrochemical Detection of Benzo[a]Pyrene-Induced DNA Damage at TP53 Oligomers : Impact of 5'-Methyl Cytosine and Bioactivation on the Genotoxicity Process
(East Carolina University, 2014)
DNA houses the blueprint that dictates how an organism will develop. However, DNA features numerous reactive sites that can be attacked by chemicals and radiation, resulting in DNA damage and possibly mutations. Chemical ...
Decadal-scale evolution of a barrier island : Insights from storm overwash and shoreline change on Ocracoke Island, NC
(East Carolina University, 2014)
Eastern North Carolina has over 300 km of barrier islands that comprise the Outer Banks and act as an important buffer from the Atlantic Ocean and boundary to the Albemarle-Pamlico Estuarine System. These islands also draw ...