Browsing Dissertations by Title
Now showing items 784-803 of 1044
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Retinoids Potentiate Clinically Relevant Cellular Responses through RARα/RXR Nuclear Receptor Synergism in Cutaneous T Cell Lymphoma
(East Carolina University, 2015-12-15)The heterogeneity of cutaneous T cell lymphoma (CTCL) has stifled treatment options and hindered cure development. Despite the heterogeneous nature of CTCLs, a hallmark of all variants is malignant T cell infiltration of ... -
Retrospective Risk Assessment of Forestry Workers in the United States: Injuries, Fatalities, and Hazards Impacting Occupational Health
(East Carolina University, 2022-12-02)Forestry (including logging) is one of the most hazardous occupations due to environmental, ergonomic, chemical, mechanical, mental, and physical components of the job. In the United States (US), workplace injuries account ... -
The Rhetorical Challenge of Whiteness within Blackboard for African American Bidialectal Students at Elizabeth City State University
(East Carolina University, 2013)This research will attempt to discover if there is a rhetorical challenge due to whiteness within Elizabeth City State University's (ECSU) Blackboard (Bb) online education system when it is utilized by African American ... -
The Rhetorical Construction of Legal Culture : Ideographs and Relationships in Appellate Opinions Addressing Same-Sex Marriage and English-Only Legislation
(East Carolina University, 2012)In my dissertation, I present a critical method that presents a framework for both a legal and rhetorical analysis of appellate opinions. The legal analysis will be a traditional form of legal analysis of an opinion, ... -
RHETORICAL LIFELINES: QUEER AND FEMINIST SURVIVAL IN RIYOKO IKEDA’S THE ROSE OF VERSAILLES
(East Carolina University, 2019-04-25)This dissertation explores the rhetorical lifelines of queer and feminist survival in the adapted animation of Riyoko Ikeda’s The Rose of Versailles. Using an interdisciplinary approach, this study examines the rhetorics ... -
Risky Business: Subsistence fishing in Tyrrell County, North Carolina
(East Carolina University, 2018-11-30)Catching fish provides inexpensive protein to low income residents living near fish producing water bodies. Tyrrell County, North Carolina, is one of the most economically challenged counties in the state. Located in the ... -
RNA polymerase II CTD Evolutionary Diversity and Associated Protein Identification in Green and Red Algae
(East Carolina University, 2014)In model eukaryotes, the C-terminal domain (CTD) of the largest subunit (RPB1) of DNA-dependent RNA polymerase II is composed of tandemly repeated heptads with the consensus sequence YSPTSPS. Both the core motif and tandem ... -
Role Conception in New Graduate Nurses: A Secondary Analysis
(East Carolina University, 2017-05-03)Background: The new graduate transition to practice process affects retention, competency development, healthcare costs, quality, and assimilation into the profession. During the transition, new graduate nurses compare the ... -
The Role of Axl and Axl-like Proteins in Murine Spermatogenesis
(East Carolina University, 2009)Mice lacking the Axl receptor tyrosine kinase (RTK) and its family members exhibit detrimental effects on their reproductive ability. AXL is localized to Sertoli cells, which are the major nurturing cells in the seminiferous ... -
The role of cardiac mitochondria in myocardial ischemia/reperfusion injury
(East Carolina University, 2012)Cardiovascular disease (CVD) exerts economic and humanitarian costs that are unparalleled by any other disease. Of the many etiologies of CVD, myocardial infarction accounts for over 50% of the associated mortality and ... -
Role of central cannabinoid receptor GPR18 in cardiovascular regulation
(East Carolina University, 2014)The primary goal of this study was to characterize the role of GPR18 in the rostral ventrolateral medulla (RVLM) in blood pressure (BP) regulation and elucidate the mechanisms involved in central GPR18 mediated hypotensive ... -
ROLE OF EPICARDIAL ADIPOSE TISSUE SECRETED INTERLEUKIN-34 IN FIBROBLAST TO MYOFIBROBLAST TRANSDIFFERENTIATION AND ATRIAL FIBROSIS
(East Carolina University, 2021-07-26)The adiposity of the heart has been proven to be significantly associated with cardiac dysfunction. Chronic low-grade inflammation of the adipose tissue and cardiac fibrosis are common complications in type 2 diabetes ... -
Role of Inflammatory Microglia in Mediating Periadolescent Nicotine-Induced Reward Sensitization
(East Carolina University, 2018-07-23)Nicotine exposure during the onset of adolescence (periadolescence) is demonstrated to sensitize the brain to the rewarding effects of various drugs of abuse. Nicotine enhances the expression of the transcription factor ... -
The role of mediators of neuronal plasticity in the circadian regulation of suprachiasmatic nucleus by light
(East Carolina University, 2009)Circadian rhythms are highly conserved physiological functions that are present in almost all living organisms. In mammals, circadian rhythms are synchronized to the environmental light:dark cycle by daily adjustments in ... -
Role of nicotinic acetylcholine receptor subtypes α4β2 and α7 in nicotine-ethanol interaction and cross-tolerance: functional correlation with cerebellar nitric oxide
(East Carolina University, 2010)The prevalent co-abuse of alcohol and tobacco products results in higher morbidity and mortality rates than those caused by either drug alone, thus posing a serious health problem. Understanding the interactive relationship ... -
The role of peroxisome proliferator-activated receptor-gamma in surfactant catabolism in the alveolar macrophage
(East Carolina University, 2009)Pulmonary alveolar proteinosis (PAP) is a lung disease characterized by surfactant accumulation in the alveolar spaces and alveolar macrophages. Although PAP is rare, surfactant abnormalities occur in many lung diseases ... -
THE ROLE OF RACE AND GENDER IN THE MENTORING EXPERIENCES AND CAREER SUCCESS OF AFRICAN AMERICAN FEMALE SENIOR EXECUTIVE ADMINISTRATORS IN HIGHER EDUCATION
(East Carolina University, 2009)From 1995 to 2005 education doctoral degrees conferred to African American females increased by 92%, however the increase in availability among this population for higher education administrator positions has not kept pace ... -
THE ROLE OF SDF-1[alpha] AS A VASCULOGENIC CHEMOKINE AND ENDOTHELIUM-ASSOCIATED CELL ADHESION MOLECULE FOR THE RECRUITMENT OF BONE MARROW-DERIVED PROGENITOR CELLS TO DEVELOPING TUMORS
(East Carolina University, 2010)Tumor vascularization is an important control point in cancer progression and its inhibition is a promising approach to cancer therapy. Stromal-derived factor-1 alpha (SDF-1 alpha or CXCL12) is a chemoattractant for ... -
Role of the Iron Storage Ferritins Dps and DpsL during the Prolonged Oxidative Stress Response of Bacteroides fragilis
(East Carolina University, 2015-12-02)Bacteroides fragilis is a Gram negative anaerobe and member of the human intestinal tract microbiome. B. fragilis serves many beneficial roles within the intestinal tract; however, its translocation to the peritoneal cavity ... -
Rules of (employee) engagement: A comprehensive model
(East Carolina University, 2016-12-15)The purpose of the study was to examine a comprehensive model of employee engagement that included a diverse set of (1) personal factors, (2) environmental factors, (3) job attitudes, (4) work outcomes and (5) health ...