Browsing Dissertations by Submit Date
Now showing items 1-20 of 1007
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Quantifying the Impact of PFAS Exposure on B Cell Development and Antibody Production
(East Carolina University, 2023-08-07)Well over 10,000 individual synthetic chemicals have been identified as per- and polyfluoroalkyl substances (PFAS). Many are used in non-stick cooking ware, medical garments, and food packaging. Numerous PFAS are environmentally ... -
Performance Avoidance, Neurocognition, and Neurophysiology in a Sample of First-Generation College Students
(East Carolina University, 2023-07-21)What motivates individuals to achieve? This study uses achievement goal orientation theory and the Reinforcement Sensitivity Theory (RST), parallel theories which attempt to explain motivational behavior, to explore ... -
m6A’s Unique and Dynamic Role in Breast Cancer Progression
(East Carolina University, 2023-07-18)Despite intense study, metastatic breast cancer is still the second leading cause of female death from cancer in the US. While many genetic lesions and environmental factors have been implicated in breast cancer progression, ... -
Evaluating the Role of Habitat Complexity in Structuring Seagrass Communities
(East Carolina University, 2023-07-18)Biogenic coastal habitats such as salt marshes, seagrasses, and oyster reefs, support diverse faunal communities and can serve as nursery areas by enhancing the abundance, growth, and survival of juvenile fish and crustaceans. ... -
Targeting the initiating proteases of the complement system using structure-based small molecule drug discovery
(East Carolina University, 2023-07-21)The complement system is an essential element of host development and immune homeostasis. This immunoregulatory enzyme cascade is driven by serine protease activation and plays critical roles in the recognition of danger ... -
THE ROLE OF THE LATERAL LINE IN EARLY LARVAL ZEBRAFISH AND CONTRIBUTION TO MULTISENSORY BEHAVIORS
(East Carolina University, 2023-07-21)The lateral line is a hair cell-based sensory system that is important for multisensory behaviors like schooling, rheotaxis, and predator/prey detection in aquatic vertebrates. This dissertation work uses the first genetic ... -
Examining Preventive Healthcare Utilization in Black College Women Through a Black Feminist-Womanist Lens
(East Carolina University, 2023-07-18)Despite higher rates of disease and mortality compared to White women, Black women often experience low rates of preventive health care including recommended screenings and vaccinations that may have a protective effect. ... -
AN EVALUATION OF WEIGHT CLASS AND MATERNAL SEXUAL HEALTH DURING PREGNANCY: THE MEDIATING ROLES OF WEIGHT BIAS AND BODY DISSATISFACTION AMONG BLACK AND WHITE WOMEN
(East Carolina University, 2023-07-11)Obesity is a national public health issue that adversely affects women of reproductive age and increases the risk for chronic issues (cardiovascular disease, type II diabetes, decreased fertility) that can cause short- and ... -
REGULATORY LINKAGE AND COORDINATED EXPRESSION OF THE CHKB AND CPT1B GENES: IMPLICATIONS FOR AN ELEVATED METABOLIC CAPACITY AND THE ORIGIN OF BROWN ADIPOSE TISSUE
(East Carolina University, 2023-07-18)The emergence of endothermy was an important event in the evolution of vertebrates. Specifically, the acquisition of BAT was a key achievement for the radiation and diversification of eutherian (placental) mammals. ... -
Sensitization of Malignant Breast Epithelial cells to Proton Radiation by Metallic Nano-Particles
(East Carolina University, 2023-07-09)Enhancing cancer treatment has garnered interest for more than 50 years. En- hancement has been considered in the evolution of treatment modalities as well as in the potential additives at the cellular level as radio-sensitizers. ... -
Feasibility of a Virtual Mindfulness-Based Intervention Modified with Accessibility Features for College Students with Chronic Health Conditions and Disabilities
(East Carolina University, 2023-07-09)There have been few published studies examining mindfulness-based interventions (MBIs) with college students with health conditions and no published studies examining MBIs in college students with disabilities. Additionally, ... -
The Feasibility and Early Efficacy of MATCH-ADTC as a Small Group Intervention
(East Carolina University, 2023-07-21)Schools are a primary site for mental health services for children. School-based mental health services (SBMH) can minimize common barriers to treatment and have less stigma than community mental health. Modular therapy ... -
IMPLEMENTING CREATIVITY IN AN INTERNATIONAL SCHOOL: A CASE STUDY OF POSSIBILITIES AND CHALLENGES
(East Carolina University, 2023-07-24)In an era of job automation and a globalized economy, educational institutions must redefine their goals to equip students for future success. International schools are gradually transitioning from focusing solely on ... -
Adverse Childhood Experiences (ACEs) Screening Implementation in Integrated Primary Care: A Mixed-Methods Pilot Study
(East Carolina University, 2023-08-07)For over two decades, adverse childhood experiences (ACEs) have been identified as a significant risk factor for multiple chronic physical and mental health conditions. Accordingly, ACEs are now highlighted as a public ... -
Semianalytical and Numerical Studies of Relativistic Heavy Ion Collisions
(East Carolina University, 2023-06-12)The quark-gluon plasma (QGP) has been produced by relativistic heavy ion collisions, and understanding its properties is a primary goal in the field of nuclear physics. This research first elucidates recent semianalytical ... -
THE π-H ELIX IN FMN-DEPENDENT REDUCTASES PROMOTES OLIGOMERIC CHANGES TO COORDINATE THE MECHANISMS OF THE ALKANESULFONATE MONOOXYGENASE SYSTEMS
(East Carolina University, 2023-08-08)Bacteria two-component flavin-dependent systems are upregulated for sulfur acquisition under sulfur limiting conditions. Two-component flavin-dependent systems are comprised of a reductase (SsuE/MsuE) that catalyzes the ... -
Mechanistic Strategies of Two-component Flavin-dependent Monooxygenases Involved in Sulfur Acquisition
(East Carolina University, 2023-08-09)All organisms require sulfur for diverse metabolic and physiological processes. Unlike mammals, bacteria are often deprived of sulfur in their natural habitat. To meet their sulfur needs, bacteria express various proteins ... -
NEUROPILIN-1 IS UPREGULATED BY HTLV-1 bZIP FACTOR AND INHIBITS CELL-TO-CELL TRANSMISSION OF HTLV-1
(East Carolina University, 2023-07-21)Human T-cell Leukemia Virus Type 1 (HTLV-1) is the etiologic agent of devastating diseases, including adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 ... -
Diversity and Survival of Macrofauna associated with a Non-Native Foundational Species
(East Carolina University, 2023-07-24)Through globalization and increased anthropogenic movement, many non-native foundation species have established across the world. These foundation species have impacted ecological communities in myriad of ways, including ... -
Development of an Instrument for Spatially Resolved, Optically Stimulated Luminescence Dosimetry of Cobble Surfaces
(East Carolina University, 2023-07-18)Optically stimulated luminescence (OSL) dosimetry is a method used to determine the amount of energy stored within a crystalline insulator due to ionizing radiation. At its most fundamental, OSL dosimetry requires optical ...