Browsing Dissertations by Title
Now showing items 112-131 of 802
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Cardiovascular Outcomes Following Xenobiotic Pulmonary Exposures
(East Carolina University, 2017-07-06)Cardiovascular disease remains the leading cause of mortality in the developed world. Over the past decades, investigations have demonstrated that pulmonary exposure to xenobiotic particulate matter promotes and exacerbates ... -
Casual video game play as an augmentation intervention for anxiety: a controlled study
(East Carolina University, 2014)Anxiety is an innate reaction to stress, but when excessive it can develop into a clinical disorder. Traditional anxiety treatments such as pharmaceuticals in combination with psychotherapy have established efficacy in ... -
Catecholamine metabolism via monoamine oxidase (MAO) within myocardium of individuals with type 2 diabetes
(East Carolina University, 2019-04-23)The primary comorbidity and cause of mortality in type 2 diabetes is cardiovascular disease. The structural and the functional cardiac remodeling observed in patients with type 2 diabetes has been shown to be driven by a ... -
Categorization in Context for Young and Older Adults
(East Carolina University, 2013)Individuals make sense of the world by grouping items into categories, or clusters of concepts that share certain characteristics. Some research has indicated that older adults may organize concepts differently than young ... -
CD44 and hyaluronan promote the bmp7 signaling response in chondrocytes
(East Carolina University, 2011)Cell-matrix interactions are important in maintaining cartilage homeostasis. Hyaluronan binding to its principal receptor CD44 is essential for such interactions. Hyaluronan-CD44 interactions are required for the retention ... -
Central GPR109A Mediates Neuronal Oxidative Stress and Pressor Response in Conscious Rats
(East Carolina University, 2016-05-03)The primary goal of this study was to characterize the role of GPR109A in the rostral ventrolateral medulla (RVLM) in blood pressure (BP) regulation and to elucidate the mechanisms involved in the hypertensive response ... -
Central α-Klotho is a Novel Regulator of Arcuate Neurons and Peripheral Metabolism
(East Carolina University, 2021-04-20)The arcuate nucleus of the hypothalamus (ARC) is a critical nexus of neuron populations that interpret peripheral signals of energy status and deliver diverse efferent outputs to metabolically active tissues. These neurons ... -
Changes in zebra finch central nervous system morphology associated with developmental cannabinoid exposure
(East Carolina University, 2012)Adolescent CNS development is a highly organized, coordinated process that is both genetically and environmentally influenced, and is characterized by a period of dynamic, activity-dependent changes in synaptic connectivity. ... -
Characterization of FtrABCD: a ferrous iron-specific transporter that is required for the virulence of Brucella abortus 2308 in mice
(East Carolina University, 2016-07-21)Brucella strains are Gram-negative bacteria that cause abortion and infertility in their natural animal hosts resulting in extensive economic losses. Humans can acquire a chronic, debilitating febrile illness known as ... -
Characterization of Pgrmcs and mPRs in oocyte maturation and ovulation in zebrafish (Danio rerio)
(East Carolina University, 2020-06-22)It is well known that progestins initiate important reproductive processes such as oocyte maturation and ovulation in vertebrates. Progestins exert functions through binding to progestin receptors. At least three families ... -
Characterization of the glucose transporters responsible for mechanical overloadstimulated glucose uptake in mouse skeletal muscle
(East Carolina University, 8/5/2020)Resistance exercise training is a recommended form of physical activity for people with type 2 diabetes due to its ability to increase skeletal muscle glucose uptake. Understanding how resistance training controls muscle ... -
Characterizing Patterns And Drivers Of Land Use/Land Cover Change Along The Atlantic Coast Barrier Beaches : Examining The Roles Of Development Pressure, Spatial Accessibility, And Policy
(East Carolina University, 2013)Within the context of land change science coastal areas are often overlooked. Coastal areas around the world and within the U.S. represent the largest concentrations of people, development, and wealth. Natural, social, ... -
CHOOSING TO ADVANCE: MOVING TEACHERS IN THE CHAPEL HILL CARRBORO CITY SCHOOLS TO A KNOWLEDGE AND SKILLS-BASED COMPENSATION SYSTEM
(East Carolina University, 2017-04-28)This study examines the design decisions, or choice architecture, that was made in planning and implementing a knowledge and skills-based career ladder in the Chapel Hill Carrboro City Schools (CHCCS). At the start of the ... -
Chronic Illness Narratives Through Facebook
(East Carolina University, 2014)The Internet has changed the process by which illness meanings are created and brought into the everyday lives of those who struggle with a chronic condition. More importantly the rapid rise and use of electronic groups ... -
Circadian activation of mast cells mediates the nocturnal response in allergic asthma
(East Carolina University, 2010)Circadian rhythm is a conserved physiological feature of most organisms. Nocturnal symptoms are a common feature of allergic asthma in humans. Patients with nocturnal asthma show circadian variation of their pulmonary ... -
Citizen Science: Is It Worth Your Time?
(East Carolina University, 2015-12-17)This dissertation investigated citizen science, a tool that connects the public to the scientific community through research-based projects and education campaigns. Benefits include volunteers adding data to long-term data ... -
The Clinical, Operational, and Financial Worlds of Neonatal Palliative Care : An Ethnographic Investigation
(East Carolina University, 2011)In this focused ethnography the researcher sought to gain a multidisciplinary perspective on the cultural context of neonatal palliative care, including Peek's three world view of clinical, operational, and financial ... -
COGNITIVE APPRAISAL OF STRESS AND COPING OF INTRADYALITIC EVENTS IN PERSONS ON HEMODIALYSIS
(East Carolina University, 2017-11-06)Although hemodialysis (HD) has the propensity to preserve and maintain life, the person on HD is at risk for adverse intradialytic events (IDEs) during the treatment such as cramping, loss of consciousness, and death. A ... -
COGNITIVE IMPAIRMENT IN PATIENTS WITH BREAST CANCER
(East Carolina University, 2020-06-22)Chemotherapy, radiation therapy, and targeted biological therapies are cancer treatments that can increase survivorship in patients with breast cancer, yet the associated cognitive side effects of therapy can significantly ... -
COLLABORATION IN THE LOOSELY COUPLED ACADEMY
(East Carolina University, 2016-04-26)This dissertation examines how loosely coupled university units collaborate in the achievement of institutional wide goals. Today's higher education institutions are being asked to do more with less as resources have ...