Browsing Dissertations by Title
Now showing items 258-277 of 1044
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Discovering mechanisms during spermatogonial differentiation that prepare male germ cells for meiosis
(East Carolina University, 2022-12-05)Spermatogenesis, the male germ cell maturation process, allows men to become and remain fertile for decades. Male fertility relies on fate decisions of different types of spermatogonia – spermatogonial stem cells maintain ... -
Discovery and investigation of a novel role for mitochondrial prohibitin in mitigating acute heart failure in endotoxic shock
(East Carolina University, 2014)Sepsis results in more than 200,000 deaths annually and is the 10th leading cause of death in the United States (US). In spite of significant advances in medical care the mortality rate for sepsis has continued to rise. ... -
DISCRIMINATING BETWEEN CARDIOLIPIN CONCENTRATION AND ACYL CHAIN COMPOSITION ON MEMBRANE BIOPHYSICAL ORGANIZATION
(East Carolina University, 2018-11-28)The pathogenesis of cardiovascular diseases (CVDs) is driven, in part, from impairment in myocardial energy metabolism. There is convincing evidence that myocardial metabolic abnormalities are fundamentally driven by ... -
Disrupted Adiponectin-Connexin43 Signaling Underlies Exacerbated Myocardial Dysfunction in Diabetic Female Rats
(East Carolina University, 2019-04-25)The 2015 American Heart Association scientific statement has advocated for sex- specific research to understand the paradoxically higher sensitivity of women to type 2 diabetes mellitus (T2DM)-associated cardiovascular ... -
Disruption of mitochondrial fitness in human preadipocytes by fatty acids
(East Carolina University, 2013)Adipose tissue lies at the core of energy metabolism, by not only releasing and taking up fatty acids (FA) according to the individuals overall surplus or deficit of energy, but also signaling other tissues to regulate ... -
Distance Education Leaders' Perspectives: A Study of How Select Higher Education Institutions Implement and Lead Online Distance Education Programs
(East Carolina University, 2008-04-09)The purpose of this research was to study the perspectives, characteristics, and experiences of ten distance education leaders at four-year, not-for-profit, degree-granting higher education institutions implementing online ... -
The Distribution Of Regulated Actomyosin States Is Central To Cardiac Muscle Regulation And Disturbance Of This Distribution Leads To Congenital Cardiomyopathies
(East Carolina University, 2009)Hypertrophic and restrictive cardiomyopathies are congenital cardiac diseases that have an incidence of over one in five hundred and may lead to sudden cardiac death. One of the main impediments to directed treatment is ... -
Diversity and Survival of Macrofauna associated with a Non-Native Foundational Species
(East Carolina University, 2023-07-24)Through globalization and increased anthropogenic movement, many non-native foundation species have established across the world. These foundation species have impacted ecological communities in myriad of ways, including ... -
Division I Athletics Directors and University Presidents : A Comparison of Sport-Related Values
(East Carolina University, 2008)The purpose of this study was to analyze the moral reasoning of university presidents and athletics directors in sport settings, an area into which few initiatives have been undertaken. Electronic surveys were used to ... -
Docosahexaenoic acid-derived metabolites target the B-cell driven immune response in obese mice
(East Carolina University, 2019-06-07)Obesity is associated with an impaired humoral immune response. As B cells mediate the humoral immune response, they are major cellular targets in diet induced obesity models. Several studies have established that B cell ... -
DOES THE DELIVERY METHOD OF FIRST-YEAR EXPERIENCE COURSES AFFECT STUDENT SUCCESS?
(East Carolina University, 2023-06-22)As state budgets are continuously tightened, and state dollars dwindle to cover only the bare necessities, resources must be carefully examined and utilized to increase efficiency and effectiveness; one such area in which ... -
DOSIMETRIC STUDY OF BETA-MINUS EMITTER PRASEODYMIUM-142 : APPLICATIONS IN MICROSPHERE BRACHYTHERAPY FOR HEPATOCELLULAR CARCINOMA AND BRACHYTHERAPY FOR OCULAR SQUAMOUS CELL CARCINOMA
(East Carolina University, 2013)A dosimetric study of the beta-minus emitter Praseodymium-142 (¹⁴²Pr) was performed and two main innovative applications of this source in brachytherapy are proposed: microsphere brachytherapy and eye plaque brachytherapy. ... -
DUAL LANGUAGE LEARNING: USING FIRST LANGUAGE AS A SCAFFOLD FOR SECOND LANGUAGE ACQUISITION AND LEARNING
(East Carolina University, 2021-04-20)For most English language learners, translanguaging strategies applied in a fully inclusive classroom are most effective for acquiring second-language competency. However, teachers of non-language subjects such as math and ... -
EARLY ALERT AND INTERVENTION SYSTEMS AND STUDENT PERSISTENCE : AN EXPLORATION OF STUDENT PERCEPTIONS
(East Carolina University, 2015-04-29)Postsecondary institutions have increasingly attempted to discover innovative methods to promote student engagement and persistence, thus combating student attrition. In recent years, the higher education landscape has ... -
EARLY ALERT PRACTICES IN NORTH CAROLINA COMMUNITY COLLEGES
(East Carolina University, 2019-04-23)Early alert systems are widely considered best practice in retention efforts to promote student success and educational goal attainment. The purpose of this quantitative study was to examine early alert practices in North ... -
Early Indication of Perioperative Acute Kidney Injury Utilizing Novel Renal Biomarkers
(East Carolina University, 2023-05-01)Acute kidney injury (AKI) is a complication of major surgery. Novel renal biomarkers have been identified that show good sensitivity for assessing the risk of AKI development much earlier than current diagnostic measures. ... -
EARLY LIFE STRESS AND PHARMACEUTICAL POLLUTANTS: DEVELOPMENTAL TOXICITY OF EMERGING AQUATIC CONTAMINANTS IN A MODEL TERRESTRIAL SPECIES
(East Carolina University, 2019-07-18)Trace amounts of pharmaceutical and personal care products are plaguing water sources around the globe, and with no current regulations, these emerging contaminants pose a threat to environmental and human health. While ... -
Early Predictors of Physical Activity and Academic Achievement in Middle School
(East Carolina University, 2016-04-19)Children and adults spend the majority of their waking time engaged in sedentary activities. These activities may be affecting the child's physical and mental health. Little research exists on the relationship between ... -
Editorial Peer Review as a Content-Shaping Mechanism in Technical Communication Journal Scholarship
(East Carolina University, 2019-07-19)Editorial peer review serves multiple functions in academic journal publishing including gatekeeping, quality control, and mentoring. As representatives of a discipline and its body of knowledge, peer reviewers evaluate ... -
EDUCATORS FOR GENDER EQUITY: PROMOTING GENDER EQUITY IN AN INTERNATIONAL ELEMENTARY SCHOOL
(East Carolina University, 2023-04-13)Disparities, bias, and inequities persist between girls and boys as the result of gender inequities in schools (Sadker & Sadker, 1994). In this participatory action research (PAR) project, I investigated how educators and ...