Browsing Dissertations by Title
Now showing items 404-423 of 802
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The intracellular proteolytic fragment of CD44 alters CD44 function in chondrocytes
(East Carolina University, 2010)CD44 is an adhesion molecule involved in several biological functions and the primary receptor for hyaluronan (HA). In cartilage, CD44 participates in the interplay between cells and the extracellular matrix to fine tune ... -
INTRINSIC EXERCISE CAPACITY ON HIND LIMB ARTERIAL LIGATION: DIFFERENTIAL IMPACT OF ACTIVE EXERCISE AND ANDROGEN SIGNALING ON POST-ISCHEMIC RECOVERY
(East Carolina University, 2018-12-21)Peripheral arterial disease (PAD) is a common disease that is frequently caused by atherosclerosis and associated thrombosis, leading to a decrease in the blood supply to the lower extremities. PAD has various treatment ... -
An Investigation of Auditory and Visual Temporal Processing in Children with Reading Disorders
(East Carolina University, 2009)Several lines of research have revealed a relationship between reading disorders (RD) and auditory temporal processing deficits. That is, subtle, yet rapid changes within an acoustic message are more difficult for individuals ... -
Investigation of the Anatomical and Physiological Changes Following the Use of a Pedicled Buccal Fat Pad Graft During Primary Palatoplasty
(East Carolina University, 2019-07-19)Children with cleft palate typically undergo primary surgery between 6-12 months of age to close the cleft in the palate and create proper muscle function for elevation and retraction of the velum for speech. About one ... -
Investigation of the Zinc binding region of Prothymosin-alpha : A spectroscopic and thermodynamic approach to study metal binding in Intrinsically disordered proteins
(East Carolina University, 2014)The goal of this study is to provide a deeper insight into how metals bind intrinsically disordered proteins (IDPs) by taking zinc binding to prothymosin-alpha as a case study. The involvement of metals in several diseases ... -
Investigations into the roles of bacteroides fragilis thioredoxins during the oxidative stress response
(East Carolina University, 2011)The Gram-negative Bacteroides fragilis is the most frequently isolated bacterium from anaerobic infections. Native to the human intestinal tract, it serves a symbiotic role breaking down complex polysaccharides and ... -
The involvement of cap-independent mRNA translation in cell fate decisions
(East Carolina University, 2014)During cell stress many biochemical processes are shut down. For example, global mRNA translation initiation is inhibited due to the disruption of the cap-dependent mRNA recruitment mechanism. One specific example of ... -
Ion Traffic Across Cellular Membranes
(East Carolina University, 2010)The cell membrane protects the delicate internal machinery of the cell and hosts a complex transport system for ion exchange with the environment. Energy is continually expended to maintain a transmembrane electrical ... -
The iron response regulator Irr controls iron homoeostasis in Brucella
(East Carolina University, 2014)Members of the genus Brucella are small, Gram-negative intracellular bacterial pathogens that are capable of infecting a wide range of mammalian hosts including humans. Brucella primarily reside inside of host macrophages. ... -
Is this Ship Covered?: The Intersection of Law, Geography, and Management of Sunken Military Craft
(East Carolina University, 2019-12-10)The legal framework protecting historic shipwrecks and other underwater cultural heritage in the United States is largely fragmented and not always effective. Factors that may influence the legal protection afforded a ... -
Issues in Rural Pediatric Primary Care
(East Carolina University, 2013)Children in rural areas experience health disparities above and beyond their urban and suburban counterparts. In order to explore the needs of children and their families in rural health care settings, two research articles ... -
Jellyfish-human interactions in North Carolina
(East Carolina University, 2013)This dissertation investigated potential drivers of jellyfish-human interactions in North Carolina. Jellyfish populations and human use of coasts are increasing; therefore, jellyfish-human interactions are poised to become ... -
Job satisfaction and intent to leave of nursing assistants in a hospital setting.
(East Carolina University, 2015)Nursing assistants are an important part of the healthcare team in hospitals. However, there has been little research about the antecedents of job satisfaction and intent to leave of nursing assistants in hospitals. The ... -
Keyboard layout in eye gaze communication access: typical vs. ALS
(East Carolina University, 2013)The purpose of the current investigation was to determine which of three keyboard layouts is the most efficient for typical as well as neurologically-compromised first-time users of eye gaze access. All participants (16 ... -
Knowledge of Sickle Cell Trait and Disease among African-American College Students
(East Carolina University, 2011)The term sickle cell disease (SCD) refers to a collection of hemoglobinopathies (inherited blood disorders) characterized by abnormal hemoglobin and produced through the homozygous inheritance of a sickle cell allele. ... -
LATINA IMMIGRANTS, HIV, AND THEIR EXPIERENCES WITH HEALTH CARE PROVIDERS IN THE U.S. AND THEIR HOME COUNTRY
(East Carolina University, 1/13/16)The intersection of factors associated with immigration in the Latina population and available culturally sensitive health care has not been well examined. There is a scarcity of research available that examines factors ... -
Layered regulation of a pathway capable of altering quinolone production in Pseudomonas aeruginosa
(East Carolina University, 2014)Pseudomonas aeruginosa is a gram negative opportunistic pathogen which commonly infects hospitalized patients and those afflicted with cystic fibrosis. P. aeruginosa communicates intercellularly via a system of small ... -
Leader-Member Relationships and Patient Safety Culture
(East Carolina University, 2017-05-03)Patient safety culture has been a national objective for years. Many different interventions have been explored in hopes of improvement, but reported statistics suggest that this issue has yet to be solved. The purpose of ... -
LEADERSHIP BEHAVIORS OF SENIOR LEADERS IN THE COMMUNITY COLLEGE SETTING
(East Carolina University, 2017-05-03)Completing GED is often a stepping-stone towards more life opportunities. Many adults who complete the GED say they do so in order to continue their education, but according to Taylor (2001) few actually go on to enter ... -
LEGISLATOR SUPPORT FOR NEW PUBLIC HIGHER EDUCATION INITIATIVES : A CASE STUDY OF THE ESTABLISHMENT OF THE EAST CAROLINA UNIVERSITY SCHOOL OF DENTAL MEDICINE
(East Carolina University, 2014)This study addresses the need for leaders in public higher education to possess a general knowledge of how new initiatives in public higher education gain support from state legislators to advance and implement their ...