Browsing Dissertations by Author "Biochemistry and Molecular Bio"
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Mechanistic Strategies of Two-component Flavin-dependent Monooxygenases Involved in Sulfur Acquisition
Somai, Shruti (East Carolina University, 2023-08-09)All organisms require sulfur for diverse metabolic and physiological processes. Unlike mammals, bacteria are often deprived of sulfur in their natural habitat. To meet their sulfur needs, bacteria express various proteins ... -
REGULATORY LINKAGE AND COORDINATED EXPRESSION OF THE CHKB AND CPT1B GENES: IMPLICATIONS FOR AN ELEVATED METABOLIC CAPACITY AND THE ORIGIN OF BROWN ADIPOSE TISSUE
Patel, Bhavin v (East Carolina University, 2023-07-18)The emergence of endothermy was an important event in the evolution of vertebrates. Specifically, the acquisition of BAT was a key achievement for the radiation and diversification of eutherian (placental) mammals. ... -
THE π-H ELIX IN FMN-DEPENDENT REDUCTASES PROMOTES OLIGOMERIC CHANGES TO COORDINATE THE MECHANISMS OF THE ALKANESULFONATE MONOOXYGENASE SYSTEMS
Aloh, Chioma Helen (East Carolina University, 2023-08-08)Bacteria two-component flavin-dependent systems are upregulated for sulfur acquisition under sulfur limiting conditions. Two-component flavin-dependent systems are comprised of a reductase (SsuE/MsuE) that catalyzes the ...