Browsing Dissertations by Author "DeWitt, Jamie"
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A Wzx-Wzy-like Polysaccharide Biosynthetic Pathway Contributes to Virulence in Brucella abortus 2308 through an Unknown Mechanism
Hopersberger, Dariel Anne (East Carolina University, 2022-08-05)Brucella abortus is an intracellular pathogen that causes spontaneous abortion in cattle and undulant fever in humans. As a member of the a-proteobacteria, B. abortus is closely related to the bacterial species Caulobacter ... -
Accuracy of Wet Bulb Globe Temperature (WBGT) Obtained from Regional Weather Station Data for Agricultural Settings in Eastern North Carolina as Proxy for WBGT Obtained from Local Heat Stress Monitors
Dillane, Danielle (East Carolina University, 2022-12-01)Introduction: Agricultural workers are at high risk of suffering from heat stress and subsequently developing heat-related illnesses (HRIs) due to the outdoor nature of their work. This risk can be exacerbated in hot, ... -
Examining the therapeutic potential of the investigational agent, 15dPMJ2, in mismatch repair proficient colon cancer
Myers, Ariel (East Carolina University, 2022-08-15)Despite the success of immune checkpoint inhibitor (ICI) therapy in many cancers, colon cancer with low microsatellite instability (MSI-L), also known as proficient mismatch repair (pMMR), does not respond to these agents. ... -
Quantifying the Impact of PFAS Exposure on B Cell Development and Antibody Production
Taylor, Krystal D (East Carolina University, 2023-08-07)Well over 10,000 individual synthetic chemicals have been identified as per- and polyfluoroalkyl substances (PFAS). Many are used in non-stick cooking ware, medical garments, and food packaging. Numerous PFAS are environmentally ...