Browsing Dissertations by Author "Fisher-Wellman, Kelsey H"
-
A UNIQUE MITOCHONDRIAL BIOENERGETIC PATHWAY UNDERLIES ACUTE MYELOID LEUKEMIA SURVIVAL AND CHEMORESISTANCE
Hagen, James T (East Carolina University, 2023-12-01)In his early research on cancer cell metabolism, Otto Warburg made the hypothesis that the respiration of cancer cells has become damaged. The insult to cancer cell respiration, Warburg proposed, was either 1) a decrease ... -
Comparison of Mitochondrial Phenotypes Across Cancers with Different Tissues of Origin
McLaughlin, Kelsey L (East Carolina University, 2021-12-06)Cancer metabolism is typically characterized by aerobic glycolysis, an increase in glucose uptake and lactate production despite adequate sufficient oxygen availability to support mitochondrial oxidative phosphorylation ...