Browsing Dissertations by Author "Litwa, Karen"
-
The Endocannabinoid System Regulates Synaptogenesis in a Cortical Spheroid Model of Fetal Neurodevelopment
Papariello, Alexis (East Carolina University, 2021-07-20)The endocannabinoid system plays a complex role in synaptogenesis and the subsequent development of neural circuitry during fetal brain development. The cannabinoid receptor type 1 controls synaptic strength at both ... -
THE HYALURONAN EXTRACELLULAR MATRIX CRITICALLY REGULATES SYNAPSE FORMATION IN DEVELOPING NEURAL NETWORKS
Wilson, Emily S (East Carolina University, 2021-04-21)The majority of neurodevelopmental disorders present with an imbalance in synaptic signal transmission. The delicate balance of excitatory to inhibitory synaptic transmission is regulated by multiple extracellular and ...