Browsing Dissertations by Author "Mansfield, Kyle"
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HUMAN RNA METHYLTRANSFERASE METTL16 AFFECTS MULTIPLE CELL PROCESSES THROUGH DIFFERENTIAL FUNCTION OF ITS DOMAINS
Talic, Emily Satterwhite (East Carolina University, 2022-11-10)ABSTRACT In recent years, disease therapies have been developed to target specific RNA and protein expression changes in the affected cells/tissue. The RNA post-transcriptional modification, methyl-6-adenosine (m6A), has ... -
Skeletal Muscle Purine Nucleotide Degradation and Atrophy: Cause or Consequence of Increased Uric Acid Production
Miller, Spencer Graham (East Carolina University, 2022-07-26)Elevated serum uric acid is a risk factor for mortality in diseases and critical illnesses associated with skeletal muscle atrophy. Uric acid is generated by xanthine oxidoreductase (XOR) and XOR inhibitors can partially ...