Browsing Dissertations by Author "Pharmacology and Toxicology"
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AMINO ACID BINDING TO AFLATOXIN B1 DURING A NOVEL FOOD TREATMENT PROCESS PROTECTS AGAINST GENOTOXICITY
Rushing, Blake Richey (East Carolina University, 2018-04-19)Access to clean food is a crucial factor in maintaining public health. Contamination of food supplies with toxic substances can lead to a myriad of health issues. As a mycotoxin, aflatoxin B1 (AFB1) is a naturally occurring ... -
Apigenin prevents chemically-induced skin tumor formation and inhibits COX-2 expression and activity in SKH-1 mouse epidermis
Kiraly, Alex J. (East Carolina University, 2012)The most common type of cancer in the United States is non-melanoma skin cancer (NMSC), with an estimated two million new cases diagnosed each year. Numerous malignancies including NMSC, colon, breast, and prostate cancer ... -
Catecholamine metabolism via monoamine oxidase (MAO) within myocardium of individuals with type 2 diabetes
Nelson, Margaret A. M. (East Carolina University, 2019-04-23)The primary comorbidity and cause of mortality in type 2 diabetes is cardiovascular disease. The structural and the functional cardiac remodeling observed in patients with type 2 diabetes has been shown to be driven by a ... -
Central GPR109A Mediates Neuronal Oxidative Stress and Pressor Response in Conscious Rats
Rezq, Samar (East Carolina University, 2016-05-03)The primary goal of this study was to characterize the role of GPR109A in the rostral ventrolateral medulla (RVLM) in blood pressure (BP) regulation and to elucidate the mechanisms involved in the hypertensive response ... -
Discovery and investigation of a novel role for mitochondrial prohibitin in mitigating acute heart failure in endotoxic shock
Mattox, Taylor A. (East Carolina University, 2014)Sepsis results in more than 200,000 deaths annually and is the 10th leading cause of death in the United States (US). In spite of significant advances in medical care the mortality rate for sepsis has continued to rise. ... -
Disrupted Adiponectin-Connexin43 Signaling Underlies Exacerbated Myocardial Dysfunction in Diabetic Female Rats
Leffler, Korin Eileen (East Carolina University, 2019-04-25)The 2015 American Heart Association scientific statement has advocated for sex- specific research to understand the paradoxically higher sensitivity of women to type 2 diabetes mellitus (T2DM)-associated cardiovascular ... -
Disruption of mitochondrial fitness in human preadipocytes by fatty acids
Rogers, Artie Carlyle (East Carolina University, 2013)Adipose tissue lies at the core of energy metabolism, by not only releasing and taking up fatty acids (FA) according to the individuals overall surplus or deficit of energy, but also signaling other tissues to regulate ... -
EARLY LIFE STRESS AND PHARMACEUTICAL POLLUTANTS: DEVELOPMENTAL TOXICITY OF EMERGING AQUATIC CONTAMINANTS IN A MODEL TERRESTRIAL SPECIES
Meadows, Jacqueline Ruth (East Carolina University, 2019-07-18)Trace amounts of pharmaceutical and personal care products are plaguing water sources around the globe, and with no current regulations, these emerging contaminants pose a threat to environmental and human health. While ... -
EFFECTS OF CANNABIDIOL ON VOCAL LEARNING AND RECOVERY FROM CNS DAMAGE
Alalawi, Ali Mohammed (East Carolina University, 2019-06-19)Cannabidiol (CBD), a non-euphorigenic compound derived from Cannabis, shows promise for improving recovery following cerebral ischemia and was recently effective for the treatment of childhood seizures caused by Dravet and ... -
Examining the therapeutic potential of the investigational agent, 15dPMJ2, in mismatch repair proficient colon cancer
Myers, Ariel (East Carolina University, 2022-08-15)Despite the success of immune checkpoint inhibitor (ICI) therapy in many cancers, colon cancer with low microsatellite instability (MSI-L), also known as proficient mismatch repair (pMMR), does not respond to these agents. ... -
Examining the therapeutic potential of the investigational agent, 15dPMJ2, in mismatch repair proficient colon cancer
Myers, Ariel (East Carolina University, 2022-08-15)Despite the success of immune checkpoint inhibitor (ICI) therapy in many cancers, colon cancer with low microsatellite instability (MSI-L), also known as proficient mismatch repair (pMMR), does not respond to these agents. ... -
EXPLORING DIFFERENCES IN INDIVIDUAL SUSCEPTIBILITY TO LIPOTOXICITY AND THE UNDERLYING MECHANISMS IN THE MITOCHONDRIA OF PRIMARY PREADIPOCYTES
Shine, Jared M (East Carolina University, 2018-07-17)Prolonged exposure to fatty acids (FAs), at levels normally seen during fasting, can be cytotoxic in vulnerable cells including preadipocytes. Prior work from our laboratory has shown that FAs cause mitochondrial inner ... -
EXPLORING THE ROLE OF ELEVATED LIPID PEROXIDATION AND GLUTATHIONE PEROXIDASE 4 IN METABOLIC SYNDROME AND CARDIAC REMODELING IN OBESITY
Katunga, Lalage Adalaide (5/16/2016)Cardiovascular disease continues to be a leading cause of global mortality. Metabolic perturbations including obesity, hyperlipidemia and type II diabetes arising from a western style diet and a more sedentary lifestyle ... -
Identification of Factors Associated with the Development and Decay of Heterologous Tolerance to Morphine in the Guinea Pig
Thompson, Benjamin (East Carolina University, 2016-05-03)It is believed that the heterologous tolerance that develops upon chronic exposure to morphine is the result of adaptive changes in the cellular signaling pathways associated with the [mu] opioid receptor. Proposed adaptive ... -
The immune and neurological impacts of developmental Bisphenol A exposure in a C57bl/6 mouse model
Franklin, Jason Neil (East Carolina University, 2014)Environmental exposure to exogenous agents during critical time points of development may be associated with the onset of deleterious effects, including immune and neurological disorders. Numerous studies have shown that ... -
INFLUENCE OF PHYSICOCHEMICAL PROPERTIES OF SILVER NANOPARTICLES ON MAST CELL AND MACROPHAGE UPTAKE AND ACTVATION: ROLE OF SCAVENGER RECEPTOR B1
Aldossari, Abdullah Ali (East Carolina University, 2018-04-09)Silver nanoparticles (AgNPs) are widely used in consumer products and the medical field for their antimicrobial properties. Some studies reported toxic effects of AgNPs but cellular uptake of AgNPs and AgNP-induced ... -
Kinin B1 Receptor Mediated Mechanisms in Hypertension
Parekh, Rohan U (East Carolina University, 2022-08-15)Hypertension continues to cause a burden on the global population as there are growing numbers of patients who present with treatment resistant hypertension. The etiology of hypertension is considered complex and multifactorial ... -
Kinin B1 Receptor Mediated Mechanisms in Hypertension
Parekh, Rohan U (East Carolina University, 2022-08-15)Hypertension continues to cause a burden on the global population as there are growing numbers of patients who present with treatment resistant hypertension. The etiology of hypertension is considered complex and multifactorial ... -
Mast cells and the IL-33/ST2 axis are essential determinants of carbon nanotube toxicity
Katwa, Pranita (East Carolina University, 2012)The rise of nanomaterial use in a variety of applications, including biomedical imaging and drug delivery, has led to concern about the potentially hazardous impacts on human health. Mast cells are critical for innate and ... -
Microglial dysfunction as an early susceptibility to Alzheimer's disease: the exacerbating role of developmental toxicity
VonderEmbse, Annalise Noelle (East Carolina University, 2017-07-25)The association between perturbations to neuroimmune development and susceptibility to adult neurodegenerative diseases, like Alzheimer's disease (AD), may undersore a putative pathogenic role for gradual microglial ...